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STX5 Antibody

  • 中文名稱:
    STX5兔多克隆抗體
  • 貨號:
    CSB-PA619754ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA619754ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) STX5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    STX5
  • 別名:
    OTTHUMP00000185028 antibody; SED5 antibody; STX5 antibody; STX5_HUMAN antibody; STX5A antibody; Syntaxin 5 antibody; Syntaxin 5A antibody; Syntaxin-5 antibody; Syntaxin5 antibody; Syntaxin5A antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Syntaxin-5 protein (55-355AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.
  • 基因功能參考文獻:
    1. Expression of the Syn5 K270R mutant in cells impairs post-mitotic Golgi reassembly PMID: 27404360
    2. Together, these data strongly suggest that syntaxin 5-mediated retrograde transport to the Golgi apparatus is a broadly conserved feature of adeno-associated virus trafficking. PMID: 25410859
    3. Stx5 might play a role in modulating VLDL-R physiology by participating in an abrasively described or completely novel Golgi-bypass pathway. PMID: 23701949
    4. serum anti-STX5 autoantibody, which was discovered by a proteomic approach, is a potential new serum marker for the diagnosis of endometriosis. PMID: 21715015
    5. Depletion of syntaxin-5 complex components results in the accumulation of autophagosomes as a result of lysosomal dysfunction, leading to decreased degradation of autophagic substrates. PMID: 21242315
    6. Syx5 is required for the maintenance of the Golgi structures but may not play a major role in the transport of vesicles carrying proteins between the ER and the Golgi compartment. PMID: 16081076
    7. hypothesize that syntaxin 5 also has trafficking-independent functions PMID: 17389686
    8. depletion of GM130 by RNA interference slows the rate of ER to Golgi trafficking in vivo; interactions of GM130 with syntaxin 5 and Rab1 are regulated by mitotic phosphorylation PMID: 18167358
    9. Study shows that the SM protein, Sly1, interacts directly with the conserved oligomeric Golgi (COG) tethering complex; Sly1-COG interaction is mediated by the Cog4 subunit, which also interacts with Syntaxin 5 through a different binding site. PMID: 19536132

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  • 亞細胞定位:
    Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type IV membrane protein. Golgi apparatus membrane.
  • 蛋白家族:
    Syntaxin family
  • 數據庫鏈接:

    HGNC: 11440

    OMIM: 603189

    KEGG: hsa:6811

    STRING: 9606.ENSP00000294179

    UniGene: Hs.654602



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