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STX16 Antibody

  • 中文名稱:
    STX16兔多克隆抗體
  • 貨號:
    CSB-PA022891ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA022891ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA022891ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) STX16 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    STX16
  • 別名:
    STX16; Syntaxin-16; Syn16
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Syntaxin-16 protein (1-300AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network.
  • 基因功能參考文獻:
    1. we here present a patient with PHP1b caused by a recurrent STX16 deletion, presenting with macrosomia, early onset obesity, and macrocephaly without other AHO symptoms. we reemphasize STX16 deletions and PHP1b as a rare cause for early onset obesity and macrosomia. PMID: 27338644
    2. STX16 microdeletion was identified in male monozygotic twins (with pseudohypoparathyroidism type 1B leading to growth hormone deficiency) and mother/grandmother (not father/grandfather or sister [their triplet with separate placenta]). [CASE STUDY] PMID: 25843330
    3. syntaxin 16 is a key regulator of cytokinesis. PMID: 24109596
    4. A patient with familial pseudohypoparathyroidism type Ib and his asymptomatic brother were found to have methylation defect at GNAS (guanine nucleotide-binding protein G) and microdeletion involving exons 4-6 of neighboring gene STX16. [CASE REPORT] PMID: 23095209
    5. De novo 3-kb STX16 deletions, reported only once previously, are infrequent but should be excluded in all cases of Pseudohypoparathyroidism-Ib, even when the family history is negative for an inherited form of this disorder. PMID: 23087324
    6. Results suggest that STX16 mediates recycling of CFTR and constitutes an important component of CFTR trafficking machinery in intestinal epithelial cells. PMID: 20826815
    7. the region of overlap between the two microdeletions likely harbors a cis-acting imprinting control element that is necessary for establishing and methylation at GNAS exon A/B, thus allowing normal G alpha(s) expression in the proximal renal tubules. I PMID: 15800843
    8. function of syntaxin 16 was specifically required for, and restricted to, the retrograde pathway PMID: 17389686
    9. Syntaxin 16 may thus play a role in neurite outgrowth and perhaps other specific dendritic anterograde/retrograde traffic. PMID: 17852734
    10. phosphorylation of RASSF1A by Aurora B is required for the recruitment of Syntaxin16 PMID: 19887622

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  • 相關疾病:
    Pseudohypoparathyroidism 1B (PHP1B)
  • 亞細胞定位:
    Golgi apparatus membrane; Single-pass type IV membrane protein.; [Isoform C]: Cytoplasm.
  • 蛋白家族:
    Syntaxin family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 11431

    OMIM: 603233

    KEGG: hsa:8675

    STRING: 9606.ENSP00000360183

    UniGene: Hs.307913



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