在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. STT3B Antibody, Biotin conjugated

STT3B Antibody, Biotin conjugated

  • 中文名稱：
    STT3B兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA823456LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) STT3B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B antibody; Homolog of yeast STT3 antibody; Oligosaccharyl transferase subunit STT3B antibody; SIMP antibody; source of immunodominant MHC associated peptides antibody; Source of immunodominant MHC-associated peptides homolog antibody; STT3 subunit of the oligosaccharyltransferase complex homolog B (S. cerevisiae) antibody; STT3 subunit of the oligosaccharyltransferase complex homolog B antibody; STT3-B antibody; Stt3b antibody; STT3B_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B protein (682-809AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets. STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation.
  • 基因功能參考文獻：
    1. Study reports that STT3B-oligosaccharyltransferase, but not STT3A-oligosaccharyltransferase, is a lipid-linked oligosaccharide hydrolase. PMID: 30181269
    2. These results reveal that the oxidoreductase activity of the STT3B-containing oligosaccharyltransferase is necessary for dengue virus infection. PMID: 28720733
    3. STT3B was significantly upregulated in hip osteoarthritis with affected versus intact cartilage, particularly in the analysis of hypertrophic and normotrophic compared with atrophic bone remodelling pattern. PMID: 27974301
    4. Post-translational modification of cotranslationally skipped sites by STT3B is hindered by the middle X residue, resulting in hypoglycosylation of consensus sites containing large hydrophobic and negatively charged side chains. PMID: 25029371
    5. Results show homozygous mutation in STT3A and in STT3B causes congenital disorders of glycosylation. PMID: 23842455
    6. Extreme C-terminal sites are posttranslocationally glycosylated by the STT3B isoform of the OST. PMID: 23530066
    7. Data show that prolonged transthyretin (TTR) unfolding induces externalization of cryptic N-glycosylation site and triggers STT3B-dependent posttranslational N-glycosylation. PMID: 22607976
    8. The STT3B isoform is required for efficient cotranslational glycosylation of an acceptor site adjacent to the N-terminal signal sequence of a secreted protein. PMID: 19167329
    9. STT3 proteins are the catalytic subunits of the oligosaccharyltransferase. Vertebrate, plant and insect genomes have an STT3A gene and a STT3B gene. SIMP is a member of the STT3B subfamily of STT3 proteins. PMID: 12887896

    顯示更多

    收起更多

  • 相關疾病：
    Congenital disorder of glycosylation 1X (CDG1X)
  • 亞細胞定位：
    Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    STT3 family
  • 組織特異性：
    Expressed in heart, brain, placenta, lung, liver, muscle, kidney and pancreas. Expressed in skin fibroblasts (at protein level).
  • 數據庫鏈接：

    HGNC: 30611

    OMIM: 608605

    KEGG: hsa:201595

    STRING: 9606.ENSP00000295770

    UniGene: Hs.475812



主站蜘蛛池模板： 人人妻人人爽人人添夜夜欢视频| 亚洲精品成人av在线| 两女女百合互慰av赤裸无遮挡| 免费人成在线观看视频高潮| 精品无码人妻一区二区三区不卡| 日韩人妻精品一区二区三区视频| 国产成人亚洲精品无码蜜芽| 少妇大叫太大太爽受不了在线观看 | 久久精品女人天堂av麻| 亚洲中文字幕在线无码一区二区| 曰韩a∨无码一区二区三区| 男女啪啪进出阳道猛进| 精品国产乱码久久久久久鸭王1| 国产精品96久久久久久| 亚洲国产精品不卡av在线 | 狠狠色丁香五月综合缴情婷婷五月 | 美丽的熟妇中文字幕| 国产成人无码网站| 中国熟妇浓毛hdsex| 爽爽午夜影视窝窝看片| 丰满少妇人妻hd高清大乳在线 | 麻豆视传媒精品av| 亚洲精品一卡2卡三卡4卡| 秋霞特色aa大片| 各处沟厕大尺度偷拍女厕嘘嘘| 国产精品午夜福利不卡120| 2021久久最新国产精品| 在线看片人成视频免费无遮挡| 又黄又爽又猛的视频免费| 国产美女爽到喷出水来视频| 亚洲人成线无码7777| 成人天堂资源www在线| 日本熟日本熟妇在线视频| 9l国产精品久久久久麻豆| 亚洲综合激情七月婷婷| 日日碰狠狠添天天爽| 大学生久久香蕉国产线看观看| 五月婷婷久久草| 中文字幕无码免费久久99| 亚洲精品国产一区二区| 欧美亅性猛交内射|