在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. STRAP Antibody

STRAP Antibody

  • 中文名稱：
    STRAP兔多克隆抗體
  • 貨號：
    CSB-PA958257
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA958257(STRAP Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA958257(STRAP Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: CSB-PA958257(STRAP Antibody) at dilution 1/400 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    STRAP
  • 別名：
    MAP activator with WD repeats antibody; MAWD antibody; PTWD antibody; Serine-threonine kinase receptor-associated protein antibody; serine/threonine kinase receptor associated protein antibody; strap antibody; STRAP_HUMAN antibody; UNR-interacting protein antibody; UNRIP antibody; WD 40 repeat protein PT WD antibody; WD-40 repeat protein PT-WD antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Full length fusion protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.
  • 基因功能參考文獻：
    1. these results suggest that STRAP increases invasion and metastasis of colorectal cancer partly through inhibiting ubiquitin-dependent degradation of beta-catenin and promoting Wnt/beta-catenin signaling PMID: 26910283
    2. Findings illuminated a novel STRAP-NOTCH1-HES1 molecular axis as a CSC regulator in colorectal cancer. PMID: 28827371
    3. MAWD and MAWBP were downregulated and associated with the differentiation grade in GC tissues. PMID: 26373288
    4. STRAP inhibits the transactivation function of Sp1 either by directly blocking its DNA binding domain or destabilizing Sp1 protein through ubiquitin-proteasome pathway in cell cycle G1 phase. PMID: 25483064
    5. Strap augments the apoptotic effects of mitochondrial p53. PMID: 25168243
    6. Coexpression of MAWBP and MAWD inhibited epithelial mesenchymal transformation, and EMT-aided malignant cell progression was suppressed in gastric cancer. PMID: 23687415
    7. Data indicate serine-threonine kinase receptor-associated protein (STRAP) as a novel regulator of the coordinated translation of collagen alpha1(I) and alpha2(I) mRNAs. PMID: 23918805
    8. both of the TPR and OB-fold domains localize to the chromatin of p53 target genes and exhibit intrinsic regulatory activity necessary for the Strap-dependent p53 response PMID: 22362889
    9. STRAP protein decreases ubiquitination of intracellular domain of Notch3 and may help to stabilize it. PMID: 21502811
    10. B-MYB acts as a positive regulator of STRAP PMID: 21148321
    11. gonucleotide pulldown identified STRAP (serine/threonine kinase receptor-associated protein) as a further protein recruited to the MMP28 promoter and acting functionally with Sp1. PMID: 20144149
    12. STRAP can act as a negative regulator of ASK1. PMID: 19880523
    13. unrip functions in the pathway of small nuclear ribonucleoproteins biogenesis PMID: 15848170
    14. biochemical evidence for the existence of another, yet atypical, SMN complex component, termed unr-interacting protein (unrip) PMID: 16159890
    15. STRAP acts as an intermediate signaling molecule linking between the phosphatidylinositol 3-kinase/PDK1 and the TGF-beta signaling pathways PMID: 16251192
    16. Gemin8 has an essential role in the proper structural organization of the SMN complex and the involvement of the heteromeric subunit containing Gemin6, Gemin7, Gemin8, and Unrip in the recruitment of Sm proteins to the snRNP assembly pathway PMID: 17023415
    17. the direct interaction of NM23-H1 and STRAP is important for the regulation of TGF-beta-dependent biological activity as well as NM23-H1 activity PMID: 17314099
    18. These results indicate that upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. PMID: 17316412
    19. an interplay between PPM1G and unrip determine compartment-specific phosphorylation patterns, localization, and function of the SMN complex PMID: 17984321
    20. Strap regulation reflects the coordinated interplay between different DNA damage-activated protein kinases, ATM and Chk2 (Checkpoint kinase 2), where phosphorylation by each kinase provides a distinct functional consequence on the activity of Strap. PMID: 18833288

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus.
  • 蛋白家族：
    WD repeat STRAP family
  • 數據庫鏈接：

    HGNC: 30796

    OMIM: 605986

    KEGG: hsa:11171

    STRING: 9606.ENSP00000392270

    UniGene: Hs.743971



主站蜘蛛池模板： 国产丝袜一区视频在线观看| 国产在线精品欧美日韩电影 | 国产亚洲精品综合一区| 1000部拍拍拍18勿入免费视频下载| 四虎亚洲中文字幕无码永久| 欧洲熟妇色xxxxx视频| 无线乱码一二三区免费看| 亚欧色一区w666天堂| 久久精品亚洲日本波多野结衣| 久久影院九九被窝爽爽| 国产偷国产偷亚洲清高孕妇| 小宝极品内射国产在线| 无尺码精品产品日韩| 小说区亚洲综合第1页| 97婷婷狠狠成为人免费视频| 国产成人精品久久| 欧美成人秋霞久久aa片| 欧洲丰满少妇a毛片| 亚洲色爱图小说专区| 国产精品亚洲欧美大片在线看| 高清破外女出血av毛片| 久久超碰极品视觉盛宴| 欧美成人一区二区三区片免费| av淘宝国产在线观看| 免费无遮挡很爽很污很黄的网站 | 伊人久久大香线蕉aⅴ色| 亚洲熟妇av一区二区三区| 国产亚洲精品a在线无码| 亚洲色成人网站www永久蜜芽 | 日日摸处处碰夜夜爽| 亚洲色成人网一二三区| 亚洲精品国产成人一区二区| 人人爽人人添人人超| 国产成人精品亚洲线观看| 内射人妻视频国内| 亚洲超清无码制服丝袜无广告| 青青草视频免费观看| 国产精品爆乳在线播放第一人称| 午夜无码性爽快影院6080| 香蕉视频在线精品视频| 欧洲熟妇色xxxx欧美老妇|