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STE2 Antibody

  • 中文名稱:
    STE2 Antibody
  • 貨號:
    CSB-PA517141XA01SVG
  • 規格:
    ¥880
  • 圖片:
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes:STE2 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 22 kDa
      Observed band size: 27 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) STE2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    STE2
  • 別名:
    Pheromone alpha factor receptor STE2 YFL026W
  • 宿主:
    Rabbit
  • 反應種屬:
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 免疫原:
    Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) STE2 protein (300-431aa)
  • 免疫原種屬:
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor for the peptide pheromone alpha factor, the mating factor of yeast.
  • 基因功能參考文獻:
    1. Interaction between Ste2p and Gpa1p takes palce before ligand binding via the Ste2p C-terminal domain and the Gpa1p N-terminal domain. PMID: 28958779
    2. yeast pheromone receptor Ste2 forms predominantly tetramers at average expression levels of 2 to 25 molecules per pixel and a mixture of tetramers and octamers at expression levels of 25-100 molecules per pixel. Ste2 is a class D GPCR found in the yeast Saccharomyces cerevisiae of the mating type a, and binds the pheromone a-factor secreted secreted by cells of the mating type a PMID: 27993568
    3. The main difference between the Ste2 and Ste3 receptor observed in this work was that while hyperactive mutations were found for Ste3, no gain-of-function mutant for the Ste2 receptor was found. this fi nding is an outcome of the different strategies the two genes have adopted for their expression. PMID: 27150158
    4. Results suggest that the G-protein-coupled receptor, Ste2 binds the inhibitory G-protein signaling, Sst2 forming a complex with antagonistic functions. PMID: 28034910
    5. Variable Dependence of Signaling Output on Agonist Occupancy of Ste2p, a G Protein-coupled Receptor in Yeast PMID: 27646004
    6. results extend previous observations and quantify the contributions of Ste2p variants to mediating cell cycle arrest versus downstream mating functionalities. PMID: 26232403
    7. we propose that the N-terminus of Ste2p plays multiple regulatory roles in controlling receptor function. PMID: 26707753
    8. A strategy for the identification of stabilized variants of the yeast alpha-factor receptor Ste2p. PMID: 25647246
    9. Results show that Ste2 is downregulated by endocytosis, both constitutive and ligand induced and its internalization requires its phosphorylation and ubiquitinylation through the action of alpha arrestins. PMID: 24820415
    10. C-terminally trancated forms of Ste2p exert dominant-negative effects. PMID: 22923047
    11. structure determination of transmembrane segments of Y4 and the yeast Ste2p G-protein-coupled receptors PMID: 22947943
    12. the identification of disulfide bonds that stabilize the active state of the yeast alpha-mating pheromone receptor Ste2p PMID: 22387470
    13. C-terminus contains multiple functional domains with differential and interdependent roles in regulating Ste2p function. PMID: 22100461
    14. a cryptic polyadenylation site is present inside the coding region of the a-specific STE2 gene, encoding the receptor for the alpha-factor PMID: 21969566
    15. study provides new information about role of specific residues of STE2, a GPCR, in signal transduction and how peptide ligand binding activates the receptor PMID: 21728340
    16. These results suggest that receptor--agonist interactions, such as those involving Ste2p, involve at least two sites, of which only one is specific for the activated conformation of the receptor. PMID: 21477594
    17. Kinetic analysis suggests that alpha-factor associates with its receptor STE2 via a two-stage process consisting of an initial binding event followed by a rearrangement of the ligand-receptor complex. PMID: 15491163
    18. Thirty-five different STE2 suppressor mutations were identified by isolating second-site suppressor mutations that restored function to defective receptors carrying either an F204S or Y266C substitution. PMID: 15667221
    19. NMR analysis; findings suggest helical subdomains existed in both the transmembrane and cytosolic tail; as the tail participates in down-regulation of Ste2p, helical regions in the tail may play a role in protein-protein interactions in endocytosis PMID: 16128581
    20. there is an interaction between specific residues in an active state, but not the resting state, of Ste2p PMID: 16314417
    21. that G protein signaling and homologous desensitization are independent cellular processes PMID: 16325780
    22. TEDS site phosphorylation of the yeast myosins I is required for ligand-induced but not for constitutive endocytosis of Ste2p PMID: 16478726
    23. signal transduction by oligomeric Ste2p receptors appears to be a cooperative process requiring an interaction between functional monomers PMID: 16709573
    24. Amiono acid residues of Ste2 that are accessible to the cytoplasmic G-protein are defined and provide an important structural framework for the interpretation of the role of Ste2 residues that function in G-protein activation. PMID: 17176053
    25. an interaction between Ste2p and Ste3p has roles in yeast cellular mating PMID: 17369365
    26. presence of an alpha-helix in the segment encompassing residues 10-30, which is perturbed around the internal Pro-24 residue PMID: 17449670
    27. set the stage for the determination of the 3D structure of these large domains of a G protein-coupled receptor in micelles using high-resolution NMR PMID: 18260136
    28. alpha-Factor induced stabilization of the dimeric form and higher order oligomeric forms of the Ste2p receptor. PMID: 18996443
    29. Study is the first to report DOPA cross-linking of a peptide hormone to a GPCR and the first to identify a residue-to-residue cross-link between Ste2p and alpha-factor, thereby defining a specific contact point between the bound ligand and its receptor. PMID: 19152328
    30. high-resolution NMR study on an 80-residue fragment of Ste2p; data support stable fold for the TM parts of TM1-TM2; NMR structure is consistent with biochemical experiments that identified the ligand-binding site within this region of the receptor PMID: 19383463
    31. Results support the conclusion that G protein-coupled receptors, including Ste2, form oligomers and not just dimers, since TM1 and TM4 are too far apart in the class A GPCRs to form contacts in the same dimer moiety. PMID: 19588927
    32. The effect of ligand (alpha-factor) on dimer formation of STE2 suggests that dimers are formed in the resting state and the activated state of the receptor by different transmembrane interactions. PMID: 19839649

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  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 4 family
  • 數據庫鏈接:

    KEGG: sce:YFL026W

    STRING: 4932.YFL026W



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