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STAM2 Antibody

  • 中文名稱:
    STAM2兔多克隆抗體
  • 貨號:
    CSB-PA022793ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: STAM2 antibody at 4.09µg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 59, 39 kDa
      Observed band size: 59 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA022793ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA022793ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) STAM2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    DKFZp564C047 antibody; Hbp antibody; Hrs-binding protein antibody; HSE1 homolog antibody; Signal transducing adapter molecule 2 antibody; Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 antibody; Signal transducing adaptor molecule 2A antibody; Signal transducing adaptor molecule 2B antibody; Signal transducing adaptor molecule antibody; STAM like protein containing SH3 and ITAM domains 2 antibody; STAM-2 antibody; Stam2 antibody; STAM2_HUMAN antibody; STAM2A antibody; STAM2B antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Signal transducing adapter molecule 2 protein (376-525AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
  • 基因功能參考文獻:
    1. The authors propose a structural organization where the AMSH-SH3 binding motif interacts with the STAM2-SH3 domain and contributes to the correct positioning of AMSH prior to polyubiquitin chains' cleavage. PMID: 27725184
    2. The VHS domain of STAM2 directs AMSH to cleave longer Lys63-linked ubiquitin chains PMID: 26601948
    3. correlation between the percentage of STAM2-positive cells and mitotic count was statistically significant in Gastrointestinal stromal tumors PMID: 24778033
    4. The study reports the solution NMR structure of the STAM2-VHS domain in complex with monoubiquitin by means of chemical shift perturbations, spin relaxation, and paramagnetic relaxation enhancements. PMID: 21121635
    5. the SH3 domain of STAM2 plays versatile roles in the context of ubiquitin mediated receptor sorting PMID: 22841719
    6. Mice carrying a gene trap insertion in the Stam2 transgene do not reveal phenotype changes; therefore, STAM2 function in the digestive tube remains elusive. PMID: 22140097
    7. report the interactions of the UIM domain and VHS-UIM construct of STAM2 with monoubiquitin (Ub), Lys(48)- and Lys(63)-linked diubiquitins. PMID: 22493438
    8. PTP1B targets the endosomal sorting machinery; dephosphorylation of regulatory sites on the endosomal sorting complex is required for transport component STAM2 PMID: 20504764
    9. Data suggested that association with hepatocyte growth factor-regulated tyrosine kinase substrate is a prerequisite for STAM2 function in early endosome. PMID: 15113837
    10. Rin1 regulates EGFR degradation in cooperation with STAM PMID: 17403676
    11. STAMs function prominently in endoplasmic reticulum-to-Golgi trafficking, most likely through direct interactions with the coat protein II complex PMID: 19054391

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  • 亞細胞定位:
    Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族:
    STAM family
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 11358

    OMIM: 606244

    KEGG: hsa:10254

    STRING: 9606.ENSP00000263904

    UniGene: Hs.17200



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