在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ST3GAL5 Antibody

  • 中文名稱:
    ST3GAL5兔多克隆抗體
  • 貨號:
    CSB-PA022755GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    ST3GAL5
  • 別名:
    3-sialyltransferase antibody; CMP-NeuAc:lactosylceramide alpha-2 antibody; CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase antibody; EC 2.4.99.9 antibody; Ganglioside GM3 synthase antibody; Lactosylceramide alpha-2,3-sialyltransferase antibody; Sialyltransferase 9 antibody; SIAT9 antibody; SIAT9_HUMAN antibody; SIATGM3S antibody; ST3 beta-galactoside alpha-2,3-sialyltransferase 5 antibody; ST3GAL antibody; ST3Gal V antibody; ST3GAL5 antibody; ST3GalV antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ST3GAL5
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D-galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer (LacCer).
  • 基因功能參考文獻:
    1. While no differences in clinical characteristics were detected in patients possessing the functional promoter haplotypes of ST3GAL5, exophthalmic values were significantly lower in patients with the ST8SIA1 haplotype, which showed a significant increase in promoter activity PMID: 29047240
    2. These cases broaden the phenotypic and genetic spectrum of GM3 synthase deficiency due to ST3GAL5 variants. Patients with intellectual disability or furthermore presenting with Rett-like phenotype should be suspected of GM3 synthase deficiency, a disorder of ganglioside biosynthesis. PMID: 27232954
    3. Data suggest that ganglioside glycosyltransferases ST3GAL5, ST8SIA1, and B4GALNT1 are S-acylated at conserved cysteine residues located close to cytoplasmic border of their transmembrane domains; ST3Gal-II is acylated at conserved cysteine residue in N-terminal cytoplasmic tail; for B4GALNT1 and ST3Gal-II, dimer formation controls their S-acylation status. PMID: 28698248
    4. Studied the miRNA expression in human hepatocellular carcinoma cell lines; 13 differentially expressed miRNAs were identified between MHCC97-H and MHCC97-L cells; and the same results were found in clinical samples. Found that ST3GAL5 was the direct target of miR-26a, miR-548l and miR-34a. PMID: 28218742
    5. Serum deprivation triggers upregulation of hST3Gal V gene expression through Runx2 activation by BMP signaling in MG-63 cells. PMID: 26729095
    6. Whole-exome sequencing of patients with salt and pepper syndrome shows a homozygous c.994G>A transition (p.E332K) in the ST3GAL5 gene. PMID: 24026681
    7. GM3 synthase deficiency, responsible for early-onset epilepsy syndrome, leads to a secondary respiratory chain dysfunction. PMID: 22990144
    8. Data demonstrate that valproic acid (VPA) transcriptionally regulates human GM3 synthase (hST3Gal V), which catalyzes ganglioside GM3 biosynthesis in ARPE-19 human retinal pigment epithelial cells. PMID: 21699754
    9. GM3 exhibits the potential to regulate the allosteric structural transition from inactive to a signaling EGFR dimer, by preventing the autophosphorylation of the intracellular kinase domain in response to ligand binding PMID: 21571640
    10. In vivo expression of the transcript gives rise to two human ST3Gal-V isoforms with distinct characteristics. PMID: 20219466
    11. ST6Gal I and ST3Gal V were positively correlated with the high risk of pediatric acute leukemia. PMID: 19709745
    12. GM3 synthase overexpression results in reduced cell motility and in caveolin-1 upregulation in human ovarian carcinoma cells PMID: 19759399
    13. GM3 synthase mRNA levels were significantly higher in differentiated human monocyte-derived macrophages compared to monocytes and in atherosclerotic aorta compared to normal aorta PMID: 19415461
    14. isolation and characterization of the promoter region PMID: 12393190
    15. enhanced expression of GM3 synthase through protein kinase C /extracellular regulated kinases-dependent cAMP-responsive element binding protein activation by phorbol 12-myristate 13-acetate is associated with the differentiation of HL-60 cells PMID: 15385432
    16. ). We sequenced genes in the region and identified a nonsense mutation in SIAT9, which is predicted to result in the premature termination of the GM3 synthase enzyme (also called lactosylceramide alpha-2,3 sialyltransferase). PMID: 15502825
    17. These results are the first demonstration of the existence of a new isoform of human GM3 synthase, which could play an important role during HL60 cell differentiation. PMID: 16934889
    18. GM3 synthase point mutation almost completely depletes human fibroblast cellular gangliosides, dampens membrane EGFR activation, and modulates related critical cell functions such as proliferation and migration PMID: 18480157
    19. Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis. Direct interaction of GM3 with VEGFR-2 is reported. PMID: 18974200

    顯示更多

    收起更多

  • 相關疾病:
    Salt and pepper developmental regression syndrome (SPDRS)
  • 亞細胞定位:
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族:
    Glycosyltransferase 29 family
  • 組織特異性:
    Ubiquitous. High expression in brain, skeletal muscle, placenta, and testis. mRNA widely distributed in human brain, but slightly elevated expression was observed in the cerebral cortex, temporal lobe, and putamen.
  • 數據庫鏈接:

    HGNC: 10872

    OMIM: 604402

    KEGG: hsa:8869

    STRING: 9606.ENSP00000366549

    UniGene: Hs.415117



主站蜘蛛池模板: 97碰碰碰人妻无码视频| 中文乱码字慕人妻熟女人妻| 亚洲色欲一区二区三区在线观看| 国产女人的高潮国语对白| 天天狠天天透天干天干| 亚洲精品一区国产欧美| 中文 在线 日韩 亚洲 欧美| 国产成人一区二区无码不卡在线| 中文天堂最新版资源www官网| 中文字幕无码精品亚洲资源网久久| 国语自产偷拍精品视频偷| 国产精品xxx在线| 麻花传媒mv在线观看| 日本一区二区a√成人片| 亚洲精品综合欧美一区二区| 亚洲午夜精品久久久久久app| 性欧美欧美巨大69| 欧美多人片高潮野外做片黑人| 99视频精品国产免费观看| 亚洲国产成人精品无码区二本 | 欧美精品18videosex性欧| 97久久草草超级碰碰碰| 在线看片人成视频免费无遮挡| 国产精品久久久久久久久人妻| 中文字幕乱码一区二区三区免费| 国产人妻xxxx精品hd| 日本高清一区二区三| 亚洲 欧美 国产 日韩 精品 | 亚洲制服丝袜av一区二区三区| 国产精品va尤物在线观看| 欧美高清大屁股xxxxx| 国产欧美精品一区二区三区四区| 狠狠色噜噜狠狠狠狠777米奇| 久久激情日本亚洲欧洲国产中文| 国产亚洲精品一区在线播放| 天堂а在线中文在线新版| 国产成人无码网站| 激情综合激情五月俺也去| 三个男人躁我一个爽视频免费| 精品无码国产自产拍在线观看| 国内老熟妇对白hdxxxx|