在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SSX1 Antibody, HRP conjugated

  • 中文名稱:
    SSX1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA614964LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SSX1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SSX1
  • 別名:
    Cancer/testis antigen 5.1 antibody; Cancer/testis antigen family 5 member 1 antibody; CT5.1 antibody; MGC150425 antibody; MGC5162 antibody; Protein SSX1 antibody; sarcoma; synovial; X chromosome related 1 antibody; SSRC antibody; SSX1 antibody; SSX1_HUMAN antibody; Synovial sarcoma antibody; Synovial sarcoma; X breakpoint 1 antibody; X breakpoint 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein SSX1 protein (112-188AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Could act as a modulator of transcription.
  • 基因功能參考文獻:
    1. SS18-SSX1 deregulates developmental programs to drive transformation by hijacking a transcriptional repressive complex to aberrantly activate gene expression PMID: 29502955
    2. Synovial sarcoma (SS) is considered as high-grade tumors with a poor prognosis. Novel therapies targeted at fusion oncogene, SS18-SSX-derived peptide vaccine, epidermal growth factor receptor, and vascular endothelial growth factor are the future hope in SS. PMID: 29893303
    3. Data indicate that the oncogene SS18-SSX1 promotes tumorigenesis by increasing the expression of SHC SH2-domain binding protein 1 (SHCBP1), which normally acts as a tumor promoting factor. PMID: 27572315
    4. In patients with Colon cancer, the expression of SSX1 gene was associated with a poor prognosis. PMID: 28631709
    5. Meta-analysis of human synovial sarcoma patient series identified two tumor-gentoype-phenotype correlations that were not modeled by the mice, namely a scarcity of male hosts and biphasic histologic features among SS18-SSX2 tumors. Re-analysis of human SS18-SSX1 and SS18-SSX2 tumor transcriptomes demonstrated very few consistent differences, but highlighted increased native SSX2 expression in SS18-SSX1 tumors. PMID: 26947017
    6. Data show that SS18/SSX tightly regulates the elevated expression of the key Wnt target AXIN2 in primary synovial sarcoma. PMID: 26905812
    7. a rare variant of the SS18-SSX1 fusion transcript, which could not be identified by routine procedures for genetic diagnosis, was detected. In addition, 8 missense mutations of cancer-related genes were confirmed PMID: 25959879
    8. SS18-SSX-induced Wnt/beta-catenin signaling appears to be of crucial biological importance in synovial sarcoma tumorigenesis and progression. PMID: 24166495
    9. The mRNA levels of SSX1 and SSX4 are associated with multiple myeloma clinical stage PMID: 24710929
    10. These results suggest that the characteristic speckle localization pattern of SS18-SSX is strongly involved in the tumorigenesis through the SSX moiety of the SS18-SSX fusion protein. PMID: 24130893
    11. Knockdown of SS18-SSX1 in synovial sarcoma inhibits viability and induces apoptosis. PMID: 23716114
    12. Study shows that the SS18-SSX1 oncogenic fusion usurps SWI/SNF-like BAF complexes, resulting in activation of Sox2, which drives proliferation. PMID: 23540691
    13. siRNA targeting of SS18-SSX1 has therapeutic potential for the treatment of synovial sarcoma. PMID: 20198325
    14. epigenetic features may define the cellular microenvironment in which SYT-SSX displays its functional effects PMID: 19936258
    15. existence of fusion with SYT in synovial sarcoma PMID: 12037676
    16. A synovial sarcoma of classic morphology contained a novel t(20;X) SS18L1(strong homology to SS18 on Ch20)/SSX1 fusion transcript in which nucleotide 1216 (exon 10) of SS18L1 was fused in-frame with nucleotide 422 (exon 6) of SSX1. PMID: 12696068
    17. RT-PCR detection of SSX1 in paraffin-embedded tissue allowed for molecular diagnosis of synovial sarcoma. PMID: 15735574
    18. demonstrate differentially expressed genes for the 2 major gene fusion variants in SS, chromosome 18 synovial sarcoma (SS18)/SSX1 and SS18/SSX2, and thereby suggest that these result in different downstream effects PMID: 16152617
    19. SYT-SSX1 induces insulin-like growth factor II expression in fibroblast cells. PMID: 16247461
    20. In conclusion, SS18-SSX and IGF-1R seem to play important but different roles in maintaining malignant growth of synovial sarcoma cells. PMID: 18267106
    21. siRNA targeting of SS18-SSX1 may have therapeutic potential in the treatment of synovial sarcomas. PMID: 18714179
    22. We evaluated the correlations among the expression levels of NY-ESO-1, LAGE-1 and SSX-1 and clinical parameters in hepatocellular carcinoma patients PMID: 19212631

    顯示更多

    收起更多

  • 相關疾病:
    A chromosomal aberration involving SSX1 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
  • 蛋白家族:
    SSX family
  • 組織特異性:
    Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and
  • 數據庫鏈接:

    HGNC: 11335

    OMIM: 312820

    KEGG: hsa:6756

    STRING: 9606.ENSP00000366118

    UniGene: Hs.434142



主站蜘蛛池模板: 45分钟免费真人视频| 少妇粉嫩小泬喷水视频| 人妻丰满熟妇ⅴ无码区a片| 人人妻人人爽人人澡av| 久久久婷婷五月亚洲97号色| 亚洲精品午夜国产va久久成人| 国产av福利久久| 忘忧草社区中文字幕www| 激情综合色综合啪啪五月丁香| 久久麻豆成人精品av| 大陆国产乱人伦| 国产成人精品成人a在线观看| 中文字幕人成乱码在线观看| 国产98在线 | 欧美| 免费无遮挡很爽很污很黄的网站| 高潮内射免费看片| 国产精品51麻豆cm传媒| 131mm少妇做爰视频| 精品久久久久久亚洲中文字幕| 无码国产午夜福利片在线观看| 人人妻在人人| 成人久久久久久久久久久| 高潮潮喷奶水飞溅视频无码| 女人的天堂a国产在线观看| 亚洲最大的成人网站| 精品无码国产污污污免费网站| 香蕉久久精品日日躁夜夜躁夏| 国产成人精品999视频| 无码少妇一区二区三区浪潮av| 国产v综合v亚洲欧美久久| 人妻中文无码久热丝袜| 乱中年女人伦av三区| 麻豆成人av不卡一二三区| 日韩加勒比一本无码精品| 国产96在线 | 韩国| 欧美最猛性xxxxx免费| 一区二区三区在线 | 欧洲| 国产一起色一起爱| 国产在线精品欧美日韩电影| 亚洲欧洲无码av电影在线观看| 熟女精品视频一区二区三区|