在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SSH1 Antibody, HRP conjugated

  • 中文名稱:
    SSH1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA837881LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SSH1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    AW551225 antibody; Coro1c antibody; coronin; actin binding protein 1C antibody; Gm1394 antibody; Gm1395 antibody; hSSH-1L antibody; mSSH 1L antibody; OTTMUSP00000031415 antibody; Protein phosphatase Slingshot homolog 1 antibody; Slingshot 1 antibody; slingshot 1L antibody; slingshot homolog 1 antibody; slingshot like 1 antibody; Slingshot1 antibody; SSH 1 antibody; SSH 1L antibody; SSH-1L antibody; SSH-like protein 1 antibody; Ssh1 antibody; SSH1_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein phosphatase Slingshot homolog 1 protein (928-1049AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
  • 基因功能參考文獻:
    1. SSH1 binds to gelsolin via actin filaments in the cytosolic fraction. Gelsolin promoted solubilization of actin filaments and SSH1 in cell-free assays and in cultured cells. PMID: 25451266
    2. the N-terminal PH-like domain plays a critical role in F-actin binding and F-actin-mediated activation of the cofilin-phosphatase activity of SSH1 PMID: 27865840
    3. Results reveal that SSH1L is upregulated in a subset of PCs and that the SSH1L/cofilin-1 signal pathway is associated positively in PC with cell migration. PMID: 25684665
    4. Authors show that viral penetration-induced calcium release facilitated herpes simplex virus type 1 intracellular trafficking through activating slingshot 1 (SSH), a phosphatase regulating actin filament dynamics. PMID: 24670325
    5. The association of IRS4 with SSH1 contributes to localized activation of cofilin in membrane protrusions. PMID: 25100728
    6. Slingshot 1 downregulation in neuronal cells inactivates cofilin to facilitate HSV-1 replication. PMID: 24418541
    7. Results identify a novel frameshift mutation in this gene implicated in disseminated superficial actinic porokeratosis in 4 Chinese families PMID: 23834120
    8. Thus this study provides evidence for a novel role of LIMK1 and SSH-1L in selectively regulating endothelial cell inflammation associated with intravascular coagulation. PMID: 24039253
    9. Our work provides evidence that supports the positive role of SSH1L in the mechanism of stem cell differentiation into cardiomyocyte-like cells. PMID: 23247370
    10. A high expression of SSH-1L in peripheral eosinophils in acute exacerbations of asthma may play a role in the activation and migration of eosinophils. PMID: 21690039
    11. EphA signaling promotes actin-based dendritic spine remodeling through slingshot 1. PMID: 22282498
    12. identified Ser 402 as a new phosphorylation site within the catalytic domain of human slingshot 1 (SSH1). PMID: 21525957
    13. Results show the significance of SSH1L in estrogen-induced osteoblastogenic differentiation in favor of adipogenic differentiation from hMSCs. PMID: 21289500
    14. SSH1 plays a critical role in cytokinesis by dephosphorylating and reactivating cofilin in later stages of mitosis PMID: 12807904
    15. findings suggest that SSH1L is activated downstream of PI3K and plays a critical role in insulin-induced membrane protrusion by dephosphorylating and activating cofilin PMID: 14645219
    16. SSH1L is locally activated by translocation to and association with F-actin in lamellipodia in response to neuregulin-1beta and 14-3-3 proteins negatively regulate SSH1L activity by sequestering it in the cytoplasm. PMID: 15159416
    17. SSH1 mutations seen in patients with disseminated superficial actinic porokeratosis PMID: 15459975
    18. a multi-protein complex consisting of SSH-1L, LIMK1, actin, and the scaffolding protein, 14-3-3zeta, is involved, along with the kinase, PAK4, in the regulation of ADF/cofilin activity PMID: 15660133
    19. Ca2+-induced cofilin dephosphorylation is mediated by calcineurin-dependent activation of SSH1L PMID: 15671020
    20. identified sites that play unique roles in the control of subcellular localization and F-actin-mediated activation of SSH1L PMID: 16513117
    21. Expression of phosphatase-dead versions of SSH proteins, SSH1, SSH2 & SSH3 results in phosphorylation/inactivation of cofilin, changes in cytoskeleton organization, loss of cell polarity, and assembly of aberrant arrays of laminin-332 in keratinocytes. PMID: 17848544
    22. PDGF participates in actin dynamics by dual regulation of cofilin activity via LIMK and SSH1L in aortic smooth muscle cells PMID: 18096821
    23. the conserved SSH-N domain of slingshot-1 plays critical roles in P-cofilin recognition, F-actin-mediated activation, and subcellular localization of SSH1 PMID: 18809681
    24. Results suggest that the formation of ROS by NADPH oxidases engages a SSH-1L-cofilin pathway to regulate cytoskeletal organization and cell migration. PMID: 19339277
    25. These results implicate 14-3-3zeta/tau heterodimers as key regulators of SSH1 activity in keratinocytes and suggest they play a role in cytoskeleton remodeling during cell migration. PMID: 19371722
    26. Data identify PKD as a central regulator of the cofilin signaling network via direct phosphorylation and regulation of SSH1L. PMID: 19567672

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.
  • 蛋白家族:
    Protein-tyrosine phosphatase family
  • 數據庫鏈接:

    HGNC: 30579

    OMIM: 606778

    KEGG: hsa:54434

    STRING: 9606.ENSP00000315713

    UniGene: Hs.199763



主站蜘蛛池模板: 国产对白老熟女正在播放| 99精品国产一区二区三区不卡| 少妇人妻av无码专区| 欧美叉叉叉bbb网站| 久久视频这里只精品| 国产三级视频在线播放线观看| 国产又色又爽又黄的免费| 人妻体内射精一区二区| av天堂永久资源网亚洲高清| 欧美日本日韩aⅴ在线视频| 亚洲精品久久久久国产| 无码国产精品一区二区免费式芒果 | 一区二区亚洲精品国产精华液| 日韩精品无码专区免费视频| 久久www成人影院| 天堂资源最新在线| 久久久不卡国产精品一区二区 | 久久99精品国产99久久6不卡 | 成人伊人青草久久综合网| 69sex久久精品国产麻豆| 无码人妻丰满熟妇区毛片| 日本一区二区三区免费播放视频站 | av天堂亚洲区无码先锋影音| 一本之道高清无码视频| 99久久无码一区人妻a片蜜| 国产片av片永久免费观看| 国产裸体美女永久免费无遮挡| 日韩亚洲欧美中文在线| 国产卡二卡三卡四卡免费网址| 亚洲精品无码专区在线播放| 丰满少妇被猛烈进入无码| 女人被做到高潮免费视频| av综合网男人的天堂| 亚洲一区二区三区av天堂| 久久久久欧美精品| 久久九九有精品国产23百花影院| 国产激情高中生呻吟视频 | 久久无码中文字幕无码| 亚洲色大成影网站www永久 | 国产精品国色综合久久| 中文亚洲无线码49vv|