在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SS18L1 Antibody

  • 中文名稱:
    SS18L1兔多克隆抗體
  • 貨號:
    CSB-PA022701GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SS18L1
  • 別名:
    Calcium-responsive transactivator antibody; CREST antibody; CREST_HUMAN antibody; KIAA0693 antibody; LP2261 antibody; MGC26711 antibody; MGC78386 antibody; sarcoma translocation gene on chromosome18like1 antibody; SS18 antibody; SS18-like protein 1 antibody; SS18L1 antibody; SS18L1 nBAF chromatin remodeling complex antibody; SSXT antibody; synovial sarcoma translocation antibody; synovial sarcoma translocation gene on chromosome 18-like 1 antibody; SYT homolog 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CREST
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide and 50% glycerol, pH 7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP.
  • 基因功能參考文獻:
    1. calcium-responsive transactivator and certain other amyotrophic lateral sclerosis-linked proteins share several features implicated in amyotrophic lateral sclerosis pathogenesis PMID: 25888396
    2. Its mutation causes amyotrophic lateral sclerosis. PMID: 24360741
    3. This study demonistrated that CREST mutations inhibited activity-dependent neurite outgrowth in primary neurons, and CREST associated with the ALS protein FUS. PMID: 23708140
    4. A synovial sarcoma of classic morphology contained a novel t(20;X) SS18L1(strong homology to SS18 on Ch20)/SSX1 fusion transcript in which nucleotide 1216 (exon 10) of SS18L1 was fused in-frame with nucleotide 422 (exon 6) of SSX1. PMID: 12696068
    5. analysis of the CREST domain that inhibits dendritic growth in cultured neurons PMID: 15866867
    6. SS18 and SS18L1 genes map within co-linear DNA segments that may have evolved through a relatively recent genomic duplication event. PMID: 16484776

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome, centromere, kinetochore.
  • 蛋白家族:
    SS18 family
  • 組織特異性:
    Ubiquitous; with lowest levels in spleen.
  • 數據庫鏈接:

    HGNC: 15592

    OMIM: 606472

    KEGG: hsa:26039

    STRING: 9606.ENSP00000333012

    UniGene: Hs.154429



主站蜘蛛池模板: 欧美艳星nikki激情办公室| 久久久久久久性潮| 国产美女裸体无遮挡免费视频| 777久久精品一区二区三区无码 | 久久zyz资源站无码中文动漫| 人妻精品久久久久中文字幕| 国产亚洲精选美女久久久久| 亚洲精品无码av中文字幕| 色拍拍欧美视频在线看| 在线天堂新版最新版在线8| 中文字幕在线精品视频入口一区| 免费国产va在线观看中文字| 伊人亚洲大杳蕉色无码| 国产熟妇另类久久久久| 日韩乱码人妻无码中文字幕视频| 久久三级中文欧大战字幕| 玖玖资源站无码专区| 欧洲精品码一区二区三区免费看 | 国产人成视频在线视频| 欧美videos另类极品| 人妻无码中文字幕永久在线| 国产综合久久亚洲综合| 国产一三四2021不卡| 女人被男人桶30分钟无遮挡动态图| 久久精品国产只有精品96| 已婚少妇美妙人妻系列| 国产精品美女久久久网av| 风韵犹存丰满大屁股熟妇| 亚洲 欧美精品suv| 天天爱天天做狠狠久久做| 无码一区二区三区| 国产无套粉嫩白浆在线| 伊人久久大香线蕉av五月天| 妺妺窝人体色www在线下载| 精品视频一区二区三区在线观看 | 日韩精品专区在线影院重磅| 中文字幕人妻熟女人妻| 成人乱人乱一区二区三区| 日韩av无码一区二区三区不卡毛片| 四虎av永久在线精品免费观看| 在线看片免费人成视频久网|