在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SRSF5 Antibody

  • 中文名稱:
    SRSF5兔多克隆抗體
  • 貨號:
    CSB-PA050022
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    SRSF5
  • 別名:
    arginine/serine-rich 5 antibody; Delayed early protein HRS antibody; Delayed-early protein HRS antibody; HRS antibody; Pre mRNA splicing factor SRP40 antibody; Pre-mRNA-splicing factor SRP40 antibody; Serine and arginine rich splicing factor 5 antibody; Serine/arginine-rich splicing factor 5 antibody; SFRS 5 antibody; SFRS5 antibody; Splicing factor antibody; Splicing factor arginine/serine rich 5 antibody; SRP 40 antibody; SRP40 antibody; SRSF5 antibody; SRSF5_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human SRp40.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
  • 基因功能參考文獻(xiàn):
    1. Study found that SRSF5 is a novel target of SRSF3. SRSF5 is overexpressed in oral squamous cell carcinoma (OSCC) and functions as an oncogene. Its downregulation in OSCC cell lines slows cell growth, cycle progression, and tumor growth. The expression of SRSF5 seems to controlled by an autoregulation mechanism. PMID: 29857020
    2. upon glucose intake, the splicing factor SRSF5 is specifically induced through Tip60-mediated acetylation on K125, which antagonizes Smurf1-mediated ubiquitylation. SRSF5 promotes the alternative splicing of CCAR1 to produce CCAR1S proteins, which promote tumor growth by enhancing glucose consumption and acetyl-CoA production. PMID: 29942010
    3. we show that ErbB3 interacts with the ESCRT-0 subunit Hrs both in the presence and absence of heregulin. This indicates an ESCRT-mediated sorting of ErbB3 to late endosomes and lysosomes, and in line with this we show that impaired ESCRT function leads to an endosomal accumulation of ErbB3. PMID: 28867611
    4. the up-regulated expression of SRSF 5-7 proteins in LC with much more profound up-regulation in SCLC than in NSCLC and suggest that up-regulation of the SRSFs is related to SCLC proliferation. Moreover, we identified SRSF5 as a novel detection marker for SCLC and pleural metastatic cancer cells. PMID: 27565915
    5. this study demonstrates that HRS acts as a key component of TLR7 signaling to orchestrate immune and inflammatory responses during EV71 infection PMID: 28854257
    6. Enhanced SRSF5 Protein Expression Reinforces Lamin A mRNA Production in HeLa Cells and Fibroblasts of Progeria Patients PMID: 26670336
    7. Suggest that SRp40 might be associated with GRalpha transcripts in systemic lupus erythematosus patients. PMID: 25665148
    8. We show that changes in alternative splicing of hnRNP A/B, affected by up regulation of SRSF5 (SRp40) or by treatment with C6-ceramide, occur within supraspliceosomes. PMID: 22100336
    9. Here, the authors report that specific SR proteins, particularly SRp40 and SRp55, promote human immunodeficiency virus type 1 (HIV-1) Gag translation from unspliced (intron-containing) viral RNA. PMID: 20427542
    10. SRp40 antagonizes ASF/SF2 and SRp55 by competing for binding to certain sites in exon 5, thereby promoting TF exon 5 exclusion, an event unique to asTF biosynthesis. PMID: 19843576
    11. SRp40 regulates the switch in splicing from production of CREMtau(2)alpha to CREMalpha PMID: 16103121

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus.
  • 蛋白家族:
    Splicing factor SR family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 10787

    OMIM: 600914

    KEGG: hsa:6430

    STRING: 9606.ENSP00000377892

    UniGene: Hs.632326



主站蜘蛛池模板: 亚洲熟妇久久国内精品| 日本肥老妇色xxxxx日本老妇| 国产乱人伦精品一区二区| 老熟妇高潮喷了╳╳╳| 在线aⅴ亚洲中文字幕| a∨在线视频播放| 国产精品无码久久综合| 久久精品一区二区三区av| 无码免费午夜福利看片| 无码av在线一本无码| 夜夜高潮夜夜爽夜夜爱爱| 国产成人亚洲综合无码精品| 高潮喷吹一区二区在线观看| 四虎永久在线精品8848a| 国产三级精品三级| 色悠久久久久久久综合网伊人 | 99久久国产成人免费网站| 国产交换配乱婬视频| 一卡二卡三卡视频| 国产精品乱码一区二区三区| 少妇与子乱在线观看| 四虎影视永久免费观看在线| 久久综合亚洲色一区二区三区| 精品一区二区三区免费播放| 中文字幕人妻a片免费看| 亚洲日本乱码一区二区产线一∨| 男女猛烈激情xx00免费视频 | 色综合天天综合网国产成人网| 狠狠色综合tv久久久久久| 色综合久久88色综合天天| 国产成人高清精品免费| 日本中文一区二区三区亚洲| 亚洲欧洲日产国码无码久久99| 成人无码www在线看免费| 秋霞午夜鲁丝片午夜精品| 肥臀熟女一区二区三区| 女人被狂躁60分钟视频| 熟妇丰满大屁股在线播放| 亚洲国产精品无码中文字2022| 亚洲日本va午夜中文字幕一区| 亚洲国产综合无码一区|