在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SRRT Antibody

SRRT Antibody

  • 中文名稱：
    SRRT兔多克隆抗體
  • 貨號：
    CSB-PA880129ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA880129ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA880129ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SRRT Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SRRT
  • 別名：
    ARS2 protein antibody; Arsenate resistance protein ARS2 antibody; Arsenite resistance protein 2 antibody; Arsenite resistance protein antibody; Arsenite-resistance protein 2 antibody; ASR2 antibody; MGC126427 antibody; Serrate antibody; Serrate RNA effector molecule antibody; Serrate RNA effector molecule homolog (Arabidopsis) antibody; Serrate RNA effector molecule homolog antibody; SRRT antibody; SRRT_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Serrate RNA effector molecule homolog protein (627-876AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription.
  • 基因功能參考文獻：
    1. Study present the human ARS2 crystal structure, which exhibits similarities and metazoan-specific differences to the plant homologue SERRATE, most notably an additional RRM domain. RRM domain is required to bind RNA, whereas a basic patch in the C-terminal leg of ARS2 mediates the interaction with FLASH. PMID: 29703953
    2. define two mutually exclusive complexes CBC-NELF-E and CBC-ARS2-PHAX, which likely act in respectively earlier and later phases of transcription PMID: 29101316
    3. ARS2 depletion negatively impacts levels of promoter-proximal RNA polymerase II at protein-coding genes. It is involved in transcription termination events within first introns of pc genes. ARS2 plays a role in transcription termination-coupled RNA turnover at short transcription units like snRNA-, replication-dependent histone-, promoter upstream transcript- and enhancer RNA-loci. PMID: 28973446
    4. 2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-kappaB, AP-1 and MAPK pathways in human proximal tubular cells. PMID: 26404762
    5. Ars2 is overexpressed in HCC and may have prognostic value; it might play an important role in HCC proliferation and miR-21 expression. PMID: 24272391
    6. Ars2 contributes to histone mRNA 3' end formation and expression and these functional properties of Ars2 are negatively regulated by interaction with 7SK RNA. PMID: 22244333
    7. These data indicate ARS2 is essential for early mammalian development and is likely involved in an essential cellular process. PMID: 18086880
    8. These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation. PMID: 19632182
    9. Validated occurrence of an unusual TG 3' splice site in intron 17 (NM_015908). PMID: 17672918
    10. Nomenclature. Original paper and GenBank submission by Rossman and Wang (1999) called the gene Asr2 (arsenite resistance protein 2) as opposed to Ars2 (arsenate resistance protein 2). PMID: 10069470

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus, nucleoplasm. Cytoplasm.
  • 蛋白家族：
    ARS2 family
  • 組織特異性：
    Ubiquitously expressed.
  • 數據庫鏈接：

    HGNC: 24101

    OMIM: 614469

    KEGG: hsa:51593

    STRING: 9606.ENSP00000314491

    UniGene: Hs.111801



主站蜘蛛池模板： 亚洲色欲色欲天天天www| 窝窝影院午夜看片| 久久这里只精品国产免费10| 色综合视频一区二区三区| 蜜桃av无码免费看永久| 国产亚洲精品国产福利你懂的| 精品国偷自产在线视频99| 无遮挡边吃摸边吃奶边做| 国产精品毛片无遮挡高清| 夜夜躁狠狠躁2021| 在线观看一区二区三区国产免费 | av大片在线无码永久免费| 两个美女裸体舌吻互扒内裤| 男女性爽大片视频免费看| 午夜亚洲精品久久一区二区| 特级做a爰片毛片免费69| 国产 在线 | 日韩| 国产在线不卡视频免费视频| 国产成年女人特黄特色毛片免| 国产精品白浆无码流出视频| 成人免费区一区二区三区| 久久精品亚洲一区二区三区浴池| 日本熟妇hdsex视频| 日本熟妇厨房bbw| 亚洲风情亚aⅴ在线发布| 国产无遮挡又黄又爽免费网站 | 亚洲小说区图片区另类春色| 曰批免费视频播放免费直播| 中文字幕在线影视| 国产精品视频| 成人影片麻豆国产影片免费观看 | 暖暖视频 免费 日本社区| 一区二区三区av高清免费波多| 国产亚洲成av人片在线观黄桃| 男人下部进女人下部视频| 国产亚洲欧洲日韩在线...| 日本边添边摸边做边爱边| 东京热加勒比无码少妇| 无码国内精品人妻少妇| 国产高清精品软件丝瓜软件| 农村乱人伦一区二区|