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  4. SRRM2 Antibody, Biotin conjugated

SRRM2 Antibody, Biotin conjugated

  • 中文名稱：
    SRRM2兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA892369LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SRRM2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SRRM2
  • 別名：
    300 kDa nuclear matrix antigen antibody; CWC21 antibody; KIAA0324 antibody; Ser/Arg-related nuclear matrix protein of 300 kDa antibody; Serine/arginine repetitive matrix protein 2 antibody; Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa antibody; Splicing coactivator subunit SRm300 antibody; SR-related nuclear matrix protein of 300 kDa antibody; SRL300 antibody; SRM300 antibody; SRRM2 antibody; SRRM2_HUMAN antibody; Tax-responsive enhancer element-binding protein 803 antibody; TaxREB803 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Serine/arginine repetitive matrix protein 2 protein (248-462AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for pre-mRNA splicing as component of the spliceosome.
  • 基因功能參考文獻：
    1. cellular complexes comprising cactin, DHX8 and SRRM2 sustain precise chromosome segregation, genome stability and cell proliferation by allowing faithful splicing of specific pre-mRNAs. PMID: 28062851
    2. The S346F mutation in SRRM2 predisposes to papillary thyroid carcinoma by affecting alternative splicing of unidentified downstream target genes. PMID: 26135620
    3. Data show that the consistent dysregulation of the RNA splicing factor SRRM2 in two different PD neuronal sources and in PD blood makes SRRM2 a strong candidate gene for PD and draws attention to the role of RNA splicing in the disease. PMID: 20161708
    4. results suggest multiple functions for Cwc21/SRm300 in the splicing process, including an important role in the activation of splicing in association with Isy1. PMID: 19789211
    5. demonstrate that SRm300, the only serine arginine-related protein known to be at the core of human catalytic spliceosomes, is a functional ortholog of Cwc21p, also interacting directly with Prp8p and Snu114p. PMID: 19854871

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  • 亞細胞定位：
    Nucleus. Nucleus speckle.
  • 蛋白家族：
    CWC21 family
  • 組織特異性：
    Expressed in liver, placenta, and white blood cells.
  • 數據庫鏈接：

    HGNC: 16639

    OMIM: 606032

    KEGG: hsa:23524

    STRING: 9606.ENSP00000301740

    UniGene: Hs.433343



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