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  4. SRPX2 Antibody

SRPX2 Antibody

  • 中文名稱：
    SRPX2兔多克隆抗體
  • 貨號：
    CSB-PA022690GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SRPX2
  • 別名：
    BPP antibody; CBPS antibody; PMGX antibody; RESDX antibody; SRPUL antibody; SRPX 2 antibody; SRPX2 antibody; SRPX2_HUMAN antibody; Sushi repeat containing protein SRPX2 antibody; Sushi repeat containing protein X linked 2 antibody; Sushi repeat protein antibody; Sushi repeat-containing protein SRPX2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human SRPX2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development.
  • 基因功能參考文獻：
    1. SRPX2 potentially acts as an independent prognostic predictor and a drug-target for hepatocellular carcinoma patients. PMID: 28654796
    2. Increased Sushi repeat-containing protein X-linked 2 is associated with progression of colorectal cancer. PMID: 25737434
    3. In rolandic epilepsy patients no major role was found for an association with SRPX2 or ELP4 genes. PMID: 24995671
    4. High SRPX2 expression is associated with gastric cancer. PMID: 24700475
    5. SRPX2 is an epilepsy- and language-associated gene that is a target of the foxhead box protein P2 (FoxP2) transcription factor. PMID: 24179158
    6. The SRPX2 protein contains the P-DUDES structural domain in its C-terminal region. This domain has significant albeit remote sequence similarity to thioredoxin-like domains, and is predicted to possess an oxidoreductase function. PMID: 209648
    7. Hypomethylation of SRPX2 appeared at the transition from adenoma to carcinoma, and was correlated with adenocarcinoma histology, microsatellite stability, and poor differentiation. PMID: 23115050
    8. SRPX2 is a novel chondroitin sulfate proteoglycan that is overexpressed in gastrointestinal cancer cells. PMID: 22242148
    9. The FOXP2-SRPX2/uPAR network provides exciting insights into molecular pathways underlying speech-related disorders. PMID: 20858596
    10. acts as regulator of ICAM1 and E-selectin during endotoxemia PMID: 20236627
    11. These findings suggest that Srpx2 regulates endothelial cell migration and tube formation and provides a new target for modulating angiogenesis. PMID: 19667118
    12. The involvement of SRPX2 in these disorders suggests an important role for SRPX2 in the perisylvian region critical for language and cognitive development. PMID: 16497722
    13. The R75K human-specific variation occurred in an important functional loop of the first sushi domain of SRPX2, indicating that this evolutionary mutation may have functional importance PMID: 17942002
    14. Interaction of SRPX2 with uPAR involved in the functioning, the development and disorders of the speech cortex. PMID: 18718938
    15. the biological functions of SRPX2 include cellular migration and adhesion to cancer cells. PMID: 19065654

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  • 相關疾病：
    Rolandic epilepsy with speech dyspraxia and mental retardation X-linked (RESDX)
  • 亞細胞定位：
    Secreted. Cytoplasm. Cell surface. Cell junction, synapse.
  • 組織特異性：
    Expressed in neurons of the rolandic area of the brain (at protein level). Highly expressed in the brain, placenta, lung, trachea, uterus, adrenal gland, heart, ovary and placenta. Weakly expressed in the peripheral blood, brain and bone marrow. Expressed
  • 數據庫鏈接：

    HGNC: 30668

    OMIM: 300642

    KEGG: hsa:27286

    STRING: 9606.ENSP00000362095

    UniGene: Hs.306339



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