在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SRPK2 Antibody

SRPK2 Antibody

  • 中文名稱：
    SRPK2兔多克隆抗體
  • 貨號：
    CSB-PA022683LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA022683LA01HU diluted at 1:100 and staining in paraffin-embedded human glioma cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, 293 whole cell lysate
      All lanes: SRPK2 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 78, 80 kDa
      Observed band size: 78 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SRPK2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SRPK2
  • 別名：
    Human serine kinase SRPK2 mRNA, complete cds antibody; Serine kinase SRPK2 antibody; Serine/arginine rich protein specific kinase 2 antibody; Serine/arginine-rich protein-specific kinase 2 antibody; Serine/threonine protein kinase SRPK2 antibody; SFRS protein kinase 2 antibody; SFRSK2 antibody; SR protein specific kinase 2 antibody; SR-protein-specific kinase 2 antibody; SRPK2 antibody; SRPK2_HUMAN antibody; SRSF protein kinase 2 C-terminal antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human SRSF protein kinase 2 protein (471-688AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，SRPK2 Antibody (CSB-PA022683LA01HU)，的標記方式是Non-conjugated。對于SRPK2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA022683LB01HU SRPK2 Antibody, HRP conjugated ELISA
    FITC CSB-PA022683LC01HU SRPK2 Antibody, FITC conjugated
    Biotin CSB-PA022683LD01HU SRPK2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Probably by phosphorylating DDX23, leads to the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.
  • 基因功能參考文獻：
    1. SRPK2 may play an important role in the progression and metastasis of prostate cancer. PMID: 29587239
    2. pausing of RNA polymerase II (RNA Pol II) initiates a signaling cascade whereby the serine/arginine protein kinase 2 (SRPK2) phosphorylates the DDX23 helicase, culminating in the suppression of R-loops. PMID: 28076779
    3. ten candidate variants were prioritised. Of these, SRPK2 (c.2044C>T[p.Arg682Trp]) and NOTCH1 (c.3835C>T[p.Arg1279Cys]), co-segregated with disease in the family; however, previous functional analyses on SRPK2 make this an unlikely candidate. Functional analyses in the variant (c.3835C>T[p.Arg1279Cys]) of the known CHD gene NOTCH1 demonstrated a non-significant decrease in signalling activity. PMID: 27989580
    4. Delta-secretase phosphorylation by SRPK2 plays a critical role in aggravating Alzheimer disease pathogenesis. PMID: 28826672
    5. In this study, it was found that the expression of SRPK2 was up-regulated in the clinical colon cancer samples. Overexpression of SRPK2 promoted the growth and migration of colon cancer cells, while knocking down the expression of SRPK2 inhibited the growth, migration and tumorigenecity of colon cancer cells. PMID: 27041240
    6. Our results indicate that phosphorylation of SRPK2 plays a crucial role in the regulation of splicing process in head and neck squamous cell carcinoma (HNSCC), and that splicing kinases can be developed as a new class of therapeutic target in HNSCC. PMID: 26853621
    7. A conserved electronegative docking groove in SRPK2 is responsible for substrate binding. PMID: 24444330
    8. the BLRF2 RS motif is phosphorylated by SRPK2 and is important for viral replication. PMID: 23326445
    9. Short-term exercise resulted in a significant increase of mRNA expression of genes encoding proteins involved in the formation of precatalytic splisosome: SRPK2. PMID: 19902070
    10. SRPK2 knock down results in hypophosphorylation of the arginine-serine (RS) domain-containing human PRP28 protein (PRP28, also known as DDX23), and destabilizes PRP28 association with the tri-snRNP. PMID: 18425142
    11. overexpression of SRPK2 is associated with phosphorylating acinus and regulating its stimulatory effects on cyclin A1 expression, contributing to leukemia cell proliferation PMID: 18559500
    12. Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle and cell death in neurons. PMID: 19592491

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus, nucleoplasm. Nucleus speckle. Chromosome.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family
  • 組織特異性：
    Highly expressed in brain, moderately expressed in heart and skeletal muscle and at low levels in lung, liver, and kidney.
  • 數據庫鏈接：

    HGNC: 11306

    OMIM: 602980

    KEGG: hsa:6733

    STRING: 9606.ENSP00000377262

    UniGene: Hs.285197



主站蜘蛛池模板： 看成年女人午夜毛片免费| 国产人妻久久精品二区三区老狼| 国产乱了伦视频大全亚琴影院| 中国极品少妇xxxxx| 精品人体无码一区二区三区| 久久亚洲国产精品亚洲老地址| 天天综合网久久综合免费人成| 亚洲人成在线观看网站无码| 精精国产xxxx视频在线| 日韩超碰人人爽人人做人人添| 亚洲精品无码av人在线观看| 国产亚洲日韩妖曝欧美| 亚洲乱妇亚洲乱妇xinglu| 胸大美女又黄的网站| 青草视频在线观看视频| 欲香欲色天天综合久久| 被拉到野外强要好爽黑人| 人妻无码久久精品| 久久午夜夜伦鲁鲁片免费无码影视| 九九热久久只有精品2| 国产九九九九九九九a片| 高中生自慰www网站| www国产亚洲精品久久麻豆| 真实国产乱子伦视频| 国产午夜成人无码免费| 国产在线永久视频| 可以看三级的网站| 天堂а√在线最新版中文| 精品国产免费人成电影在线看| 精品无码国产自产拍在线观看| 无码人妻精品一区二区三区99不卡| 免费观看又污又黄在线观看| 四虎永久在线精品8848a| 麻豆一区二区99久久久久| 窝窝午夜精品一区二区| 国产精品欧美福利久久| 亚洲综合精品成人| 国产白嫩护士被弄高潮| 婷婷四房综合激情五月| 国产亚洲中文日韩欧美综合网| 婷婷综合缴情亚洲|