在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SRCIN1 Antibody

SRCIN1 Antibody

  • 中文名稱：
    SRCIN1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA003616
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HepG2 cells using p140Cap Polyclonal Antibody
    • Western Blot analysis of 293T HELA cells using p140Cap Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SRCIN1
  • 別名：
    p130Cas associated protein antibody; p130Cas-associated protein antibody; P140 antibody; p140Cap antibody; SNAP-25-interacting protein antibody; SNIP antibody; SRC kinase signaling inhibitor 1 antibody; SRCIN1 antibody; SRCN1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human p140Cap.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
  • 基因功能參考文獻(xiàn)：
    1. SRCIN1 functions to inhibit the proliferation and EMT of human liver cancer HepG2 cells. PMID: 28550679
    2. Data indicate that the major mechanism is the ability of p140Cap to interfere with ERBB2-dependent activation of Rac GTPase-controlled circuitries. PMID: 28300085
    3. Study demonstrates a critical role of presynaptic cadherin/catenin/p140Cap cell adhesion complexes in stabilizing functional synapses and spines in the developing neocortex. PMID: 28641114
    4. SRCIN1 underexpression is associated with Osteosarcoma. PMID: 27513473
    5. Together, these results demonstrate that Srcin1 contributes to CRC carcinogenesis, invasion and metastasis. These findings provide a rationale for a mechanistic approach to CRC treatment based on the development of Srcin1-targeted therapies PMID: 28393242
    6. miR-211 may function as an oncogenic miRNA in non-small cell lung cancer, partly by regulating SRCIN1 PMID: 26277787
    7. miR-346 may function as an oncogenic miRNA and mediate chemosensitivity to docetaxel through targeting SRCIN1 in breast cancer PMID: 27913185
    8. these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis, stabilization and synaptic function through the regulation of p140Cap PMID: 25771685
    9. these findings suggest that miR-374a functions as a candidate oncogene in GC by directly targeting SRCIN1 PMID: 25554419
    10. Findings indicate the role of miR-150 as an oncogene in lung cancer through the inhibition of SRC kinase signalling inhibitor 1 (SRCIN1) translation. PMID: 24456795
    11. p140Cap phosphorylation sites and binding to Csk and Abl kinase PMID: 23383002
    12. p140Cap immobilizes E-cadherin at the cell membrane and inhibits EGFR and Erk1/2 signalling, blocking scatter and proliferation of cancer cells. PMID: 20453886
    13. provides the first evidence that p140Cap is a novel negative regulator of tumour growth PMID: 17525734
    14. Expression correlated significantly with unfavourable overall survival, suggesting that SNIP/p140Cap may be a useful diagnostic and prognostic marker, aas well as therapeutic target, in breast cancer. PMID: 18475297

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cell junction, synapse, postsynaptic density.
  • 蛋白家族：
    SRCIN1 family
  • 組織特異性：
    Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29506

    OMIM: 610786

    KEGG: hsa:80725

    STRING: 9606.ENSP00000264659

    UniGene: Hs.448872



主站蜘蛛池模板： 国产一区二区无码蜜芽精品| 无码av高潮抽搐流白浆| 久久精品欧美日韩精品| 成人国产精品无码网站| 欧美国产亚洲日韩在线二区| 手机在线看永久av片免费| 99热这里有精品| 国产亚洲产品影视在线产品| 国产精品成人观看视频国产奇米| 99精品人妻少妇一区二区| 色综合久久久久久久久久| 亚洲gv天堂gv无码男同| 在线观看国产精品va| 国产伦久视频免费观看视频| 国内精品国产成人国产三级| 国产成人综合亚洲精品| 欧美成 人 在线播放视频| 精品国产三级a∨在线| 国产真实夫妇交换视频| av国産精品毛片一区二区网站| 樱花草在线社区www中国| 欧美日韩午夜群交多人轮换| 久久精品国产精品亚洲下载| 欧美特黄特色三级视频在线观看| 好爽好黄的视频| 人妻精油按摩bd高清中文字幕| 97一期涩涩97片久久久久久久| 久久99精品国产免费观观| 久久婷婷人人澡人人爽人人爱| 欧美变态暴力牲交videos| 国产精品久久久久久tv| 国产精品亚洲综合一区二区三区| 色婷婷狠狠久久综合五月| 亚洲 欧美 另类 制服 日韩| 男女啪啪网站大全免费| 绝顶丰满少妇av无码| 97se亚洲国产综合自在线尤物| 无码三级中文字幕在线观看| 无码人妻一区二区三区在线| 欧美老妇牲交videos| 曰韩a∨无码一区二区三区|