在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SRCIN1 Antibody

SRCIN1 Antibody

  • 中文名稱：
    SRCIN1兔多克隆抗體
  • 貨號(hào)：
    CSB-PA003616
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HepG2 cells using p140Cap Polyclonal Antibody
    • Western Blot analysis of 293T HELA cells using p140Cap Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SRCIN1
  • 別名：
    p130Cas associated protein antibody; p130Cas-associated protein antibody; P140 antibody; p140Cap antibody; SNAP-25-interacting protein antibody; SNIP antibody; SRC kinase signaling inhibitor 1 antibody; SRCIN1 antibody; SRCN1_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human p140Cap.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance.
  • 基因功能參考文獻(xiàn)：
    1. SRCIN1 functions to inhibit the proliferation and EMT of human liver cancer HepG2 cells. PMID: 28550679
    2. Data indicate that the major mechanism is the ability of p140Cap to interfere with ERBB2-dependent activation of Rac GTPase-controlled circuitries. PMID: 28300085
    3. Study demonstrates a critical role of presynaptic cadherin/catenin/p140Cap cell adhesion complexes in stabilizing functional synapses and spines in the developing neocortex. PMID: 28641114
    4. SRCIN1 underexpression is associated with Osteosarcoma. PMID: 27513473
    5. Together, these results demonstrate that Srcin1 contributes to CRC carcinogenesis, invasion and metastasis. These findings provide a rationale for a mechanistic approach to CRC treatment based on the development of Srcin1-targeted therapies PMID: 28393242
    6. miR-211 may function as an oncogenic miRNA in non-small cell lung cancer, partly by regulating SRCIN1 PMID: 26277787
    7. miR-346 may function as an oncogenic miRNA and mediate chemosensitivity to docetaxel through targeting SRCIN1 in breast cancer PMID: 27913185
    8. these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis, stabilization and synaptic function through the regulation of p140Cap PMID: 25771685
    9. these findings suggest that miR-374a functions as a candidate oncogene in GC by directly targeting SRCIN1 PMID: 25554419
    10. Findings indicate the role of miR-150 as an oncogene in lung cancer through the inhibition of SRC kinase signalling inhibitor 1 (SRCIN1) translation. PMID: 24456795
    11. p140Cap phosphorylation sites and binding to Csk and Abl kinase PMID: 23383002
    12. p140Cap immobilizes E-cadherin at the cell membrane and inhibits EGFR and Erk1/2 signalling, blocking scatter and proliferation of cancer cells. PMID: 20453886
    13. provides the first evidence that p140Cap is a novel negative regulator of tumour growth PMID: 17525734
    14. Expression correlated significantly with unfavourable overall survival, suggesting that SNIP/p140Cap may be a useful diagnostic and prognostic marker, aas well as therapeutic target, in breast cancer. PMID: 18475297

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse, presynapse. Cell junction, synapse, postsynapse. Cell junction, synapse, postsynaptic density.
  • 蛋白家族：
    SRCIN1 family
  • 組織特異性：
    Expressed in some primary breast carcinomas where its presence is significantly associated with increased tumor size. Not detected in normal breast tissue.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29506

    OMIM: 610786

    KEGG: hsa:80725

    STRING: 9606.ENSP00000264659

    UniGene: Hs.448872



主站蜘蛛池模板： 丁香五月缴情在线| 夜夜嗨av一区二区三区| 刺激一区仑乱| 亚洲色无码国产精品网站可下载| 99视频国产精品免费观看| 国产色秀视频在线播放| 性生交大片免费看女人按摩| 中文人妻无码一区二区三区信息| 国产巨大爆乳在线观看| 奇米影视7777狠狠狠狠影视| 中文字幕 制服 亚洲 另类| 少妇性l交大片| 国产美女裸体丝袜喷水视频 | 国产精品老熟女露脸视频| 国产成人av无码永久免费一线天| 国色天香社区视频| 亚洲精品一区| 女人被狂躁c到高潮喷水电影| 国内精品久久人妻无码网站| 日本特黄aaaaaa大片| 久久人人爽人人人人片| 久久se精品一区精品二区| 国产va免费精品观看| 中文字幕人乱码中文| 久久婷婷五月综合色一区二区| 日本又黄又潮娇喘视频| 高清国产在线拍揄自揄视频| 无码丰满熟妇juliaann与黑人| 亚洲国产精品久久久久久| 国产又爽又黄又刺激的视频| 狠狠色色综合网站| 99这里只有精品| 久久亚洲精品国产精品婷婷| 国产精品成人午夜久久| 老熟妇高潮一区二区三区| 精品国产久九九| 亚洲国产av导航第一福利网| 少妇高潮灌满白浆毛片免费看| 中文乱码字幕视频观看网站免费| 欧美日本特级婬片视频| 免费精品99久久国产综合精品|