在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SPTBN1 Antibody

  • 中文名稱(chēng):
    SPTBN1兔多克隆抗體
  • 貨號(hào):
    CSB-PA022635GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    SPTBN1
  • 別名:
    Beta G spectrin antibody; Beta II spectrin antibody; Beta spectrin 2 antibody; Beta spectrin II antibody; Beta-II spectrin antibody; betaSpII antibody; brain 1 antibody; ELF antibody; Embryonic liver beta fodrin antibody; Fodrin beta chain antibody; non-erythroid beta chain 1 antibody; Spectrin antibody; Spectrin beta chain antibody; Spectrin, beta, non erythrocytic 1 antibody; Spectrin, non erythroid beta chain 1 antibody; SPTB2 antibody; SPTB2_HUMAN antibody; SPTBN1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Human SPTBN1-Specific
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
  • 基因功能參考文獻(xiàn):
    1. c-Met overexpression, HER-2 gene amplification, and SPTBN1-ALK gene fusion can coexist in lung adenocarcinoma and may become a potential biomarker of cancer refractory to crizotinib, chemotherapy, and radiotherapy as well as of a relatively poor prognosis. PMID: 27496196
    2. Subjects whose head and neck tumors expressed spectrin were 4.60 times more likely (hazard ratio; 95% confidence interval: 1.88-11.25) to die at any given time when compared with those without spectrin (P = .001). PMID: 27095047
    3. TGF-beta1 and ELF protein are potential and reliable biomarkers for predicting prognosis in HCC patients after hepatic resection. PMID: 25880619
    4. betaII spectrin is critical for normal myocyte electric activity. Dysfunction in the betaII spectrin-dependent cytoskeleton in cardiomyocytes contributes to human arrhythmia. PMID: 25632041
    5. decreased SPTBN1 and kallistatin gene expression associated with decreased relapse-free survival in hepatocellular carcinoma PMID: 25307947
    6. in human HCC tissues, SPTBN1 expression correlated negatively with expression levels of STAT3, ATF3, and CREB2; SMAD3 expression correlated negatively with STAT3 expression PMID: 25096061
    7. genetic association study in population of 1,012 Han women in China: Data suggest that an SNP in SPTBN1 (rs11898505) is associated with osteoporotic fractures and bone mineral density of lumbar spine in aging women. PMID: 22798246
    8. Results suggest that epigenetic silencing of SPTBN1 (beta2SP) is a new potential causal factor in BWS patients. PMID: 20739274
    9. reduced SPTBN1 expression correlated with shorter survival of pancreatic cancer patients, suggesting a tumor suppressor function of this gene PMID: 20886430
    10. High affinity and slow overall kinetics of association/dissociation of beta II-spectrin may suit it well to a role in strengthening cell junctions and providing stable anchorage for transmembrane proteins at points specified by cell-adhesion molecules. PMID: 12820899
    11. Quantitative analysis of erythrocyte membrane proteins revealed increase in beta-spectrin from patients with homozygous and heterozygous forms of beta-thalassemia. PMID: 15310273
    12. ankyrin-G and beta(2)-spectrin are functional partners in biogenesis of the lateral membrane of epithelial cells PMID: 17074766
    13. because both the T2159E mutant and the wild-type allow neuritogenesis, we conclude that the short C-terminal betaII-spectrin is phosphorylated during this process PMID: 17088250
    14. TGF-beta signaling and Smad adaptor embryonic liver fodrin (ELF) suppress human hepatocarcinogenesis, potentially through cyclin D1 deregulation. PMID: 17546056
    15. E-cadherin thus requires both ankyrin-G and beta-2-spectrin for its cellular localization in early embryos as well as cultured epithelial cells. PMID: 17620337
    16. Our results therefore indicate the importance of N-terminal region for lipid-binding activity of the beta-spectrin ankyrin-binding domain and its substantial role in maintaining the spectrin-based skeleton distribution. PMID: 17716929
    17. Characterization of the 2p21 breakpoint identified the SPTBN1 gene in myeloproliferative disorders. PMID: 18262053
    18. ELF, a TGF-beta adaptor and signaling molecule, functions as a critical adaptor protein in TGF-beta modulation of angiogenesis as well as cell cycle progression. PMID: 18704924

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, M line.; [Isoform 2]: Cell membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族:
    Spectrin family
  • 組織特異性:
    Isoform 2 is present in brain, lung and kidney (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 11275

    OMIM: 182790

    KEGG: hsa:6711

    STRING: 9606.ENSP00000349259

    UniGene: Hs.503178



主站蜘蛛池模板: 亚洲人成色777777精品音频| 国产av亚洲精品久久久久久小说| 国产高清在线精品二区| 亚洲成av人无码综合在线观看| 欧美丰满熟妇hdxx| 亚洲福利国产网曝| 国产婷婷亚洲999精品小说| 国产女人抽搐喷浆视频| 国产波霸爆乳一区二区| 尤物yw193无码点击进入| 欧美日激情日韩精品嗯| 国产精品青青青高清在线| 日日av拍夜夜添久久免费| 欧美乱妇高清无乱码在线观看| 中文字幕人成乱码熟女香港| 少妇人妻中文字幕hd| 中文字幕亚洲码在线观看| 老熟女五十路乱子交尾中出一区 | 欧美精品免费观看二区| 中文无码一区二区不卡αv| 国内揄拍国内精品人妻| 四虎永久在线精品免费无码| 开心婷婷五月激情综合社区| 久久婷婷五月国产色综合| 国产成人无码精品久久久性色 | 人成午夜免费大片| 99国产精品久久久久久久成人热| 山东熟女啪啪哦哦叫| 国产一区二区怡红院| 欧洲专线一区二区三区| 国产freexxxx性播放麻豆| 国内精品久久久久伊人av| 三上悠亚的av片在线无码| 亚洲精品国产自在现线最新| 欧美日韩综合一区二区三区| 日韩中文字幕免费视频| 黄网站色视频免费国产 | 一道久在线无码加勒比| 亚洲 欧美日韩 综合 国产| 亚洲中文久久精品无码照片| 久久www成人免费直播|