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  4. SPRTN Antibody, FITC conjugated

SPRTN Antibody, FITC conjugated

  • 中文名稱：
    SPRTN兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA863937LC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SPRTN Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SPRTN
  • 別名：
    SPRTN antibody; C1orf124 antibody; DVC1 antibody; UNQ1880/PRO4323 antibody; SprT-like domain-containing protein Spartan antibody; DNA damage protein targeting VCP antibody; DVC1 antibody; Protein with SprT-like domain at the N terminus antibody; Spartan antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human SprT-like domain-containing protein Spartan protein (1-239AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a key role in maintaining genomic integrity. DPCs are highly toxic DNA lesions that interfere with essential chromatin transactions, such as replication and transcription, and which are induced by reactive agents, such as UV light or formaldehyde. Associates with the DNA replication machinery and specifically removes DPCs during DNA synthesis. Acts as a pleiotropic protease for DNA-binding proteins cross-linked with DNA, such as TOP1, TOP2A, histones H3 and H4. Mediates degradation of DPCs that are not ubiquitinated, while it is not able to degrade ubiquitinated DPCs. SPRTN activation requires polymerase collision with DPCs followed by helicase bypass of DPCs. Involved in recruitment of VCP/p97 to sites of DNA damage. Also acts as an activator of CHEK1 during normal DNA replication by mediating proteolytic cleavage of CHEK1, thereby promoting CHEK1 removal from chromatin and subsequent activation. Does not activate CHEK1 in response to DNA damage. May also act as a 'reader' of ubiquitinated PCNA: recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis.
  • 基因功能參考文獻：
    1. e show that SPRTN is a DNA-dependent mammalian protease required for resolving cytotoxic DNA-protein crosslinks (DPCs)- a function that had only been attributed to the metalloprotease Wss1 in budding yeast. We provide genetic evidence that SPRTN and Wss1 function distinctly in vivo to resolve DPCs PMID: 27852435
    2. Loss of SPRTN results in failure to repair DNA-protein crosslinks (DPCs) and hypersensitivity to DPC-inducing agents. PMID: 27871365
    3. SPRTN protease represents a specialized DNA replication-coupled DPC repair pathway essential for DNA replication progression and genome stability. PMID: 27871366
    4. Spartan has a DNA-dependent protease activity degrading certain proteins bound to DNA. PMID: 28053116
    5. DNA binding by SPARTAN regulates the targeting of Poleta to damage sites after UV exposure, and this function contributes highly to its DNA-damage tolerance function. PMID: 27838458
    6. These findings offer new insights into the determinants of PIP box for PCNA binding. PMID: 27084448
    7. USP1, p21 and Spartan are translesion DNA synthesis regulators. (Review) PMID: 26002196
    8. Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features. PMID: 25261934
    9. The results suggest that Spartan negatively regulates POLD3 function in Rev1/Pol zeta-dependent translesion synthesis. PMID: 23254330
    10. Spartan is recruited to sites of stalled replication via ubiquitinated PCNA and plays an important role to prevent mutations associated with replication of damaged DNA. PMID: 22894931
    11. Authors propose that Spartan promotes genomic stability by regulating the choice of rescue of stalled replication fork, whose mechanism includes its interaction with ubiquitin-conjugated PCNA and protection against PCNA deubiquitylation. PMID: 22987070
    12. DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks. PMID: 23042605
    13. DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage. PMID: 23042607
    14. C1orf124 acts at multiple steps in TLS, stabilizes RAD18 and ubiquitinated PCNA at damage sites, and facilitates the switch from replicative to TLS polymerase to bypass DNA lesion. PMID: 22902628
    15. Spartan promotes an unexpected feed-forward loop to enhance PCNA ubiquitylation and translesion DNA synthesis. PMID: 22681887

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  • 相關(guān)疾病：
    Ruijs-Aalfs syndrome (RJALS)
  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Spartan family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 25356

    OMIM: 616086

    KEGG: hsa:83932

    STRING: 9606.ENSP00000295050

    UniGene: Hs.554892



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