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  4. SPRR2A Antibody, Biotin conjugated

SPRR2A Antibody, Biotin conjugated

  • 中文名稱：
    SPRR2A兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA842658LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SPRR2A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    2 1 antibody; 2-1 antibody; Small proline rich protein 2A antibody; Small proline-rich protein 2A antibody; SPR 2A antibody; SPR-2A antibody; SPR2A_HUMAN antibody; SPRR2A antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Small proline-rich protein 2A protein (1-72AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
  • 基因功能參考文獻：
    1. SPRR2a modulates ZEB-1 signaling by way of miR-200c/141-associated epithelial mesenchyme transition through SH3-domain networks and contributes to benign and malignant wound-healing responses. PMID: 24123265
    2. SPRR2A-associated tumor behavior was mimicked by MUC1 shRNA, which induced EMT and, like SPRR2A+ cells, showed reduced metastatic capabilities PMID: 23728799
    3. SPRR2A functions as a suppressor of p53-dependent transcriptional activity, which otherwise might impede cellular processes needed for epithelial wound repair responses. PMID: 22731250
    4. Small proline-rich proteins (SPRR2A) function as SH3 domain ligands, increase resistance to injury and are associated with epithelial-mesenchymal transition (EMT) in cholangiocytes. PMID: 18155796
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Cornifin (SPRR) family
  • 數據庫鏈接：

    HGNC: 11261

    OMIM: 182267

    KEGG: hsa:6700

    STRING: 9606.ENSP00000376423

    UniGene: Hs.355542



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