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SPINT1 Antibody

  • 中文名稱:
    SPINT1兔多克隆抗體
  • 貨號:
    CSB-PA022584GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    HAI 1 antibody; HAI antibody; HAI-1 antibody; HAI1 antibody; Hepatocyte growth factor activator inhibitor type 1 antibody; Kunitz type protease inhibitor 1 antibody; Kunitz-type protease inhibitor 1 antibody; MANSC2 antibody; Serine peptidase inhibitor Kunitz type 1 antibody; SPINT1 antibody; SPIT1_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human SPINT1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).
  • 基因功能參考文獻:
    1. The SPINT1 expression was associated with extrathyroidal invasion, lymphovascular invasion, lymph node metastasis, advanced TNM stage, and a higher risk of recurrence in differentiated thyroid cancer. PMID: 29532159
    2. HAI-1 is upregulated in pancreatic intraepithelial neoplasia and broadly expressed in pancreatic ductal adenocarcinoma (PDAC) cells. However, PDAC cases having areas of reduced HAI-1 immunoreactivity may show shorter disease-free survival. PMID: 29202869
    3. In this work, KLK14 binding to either hepatocyte growth factor activator inhibitor type-1 (HAI-1) or type-2 (HAI-2) was essayed using homology modeling, molecular dynamic simulations and free-energy calculations through MM/PBSA and MM/GBSA. KLK14 was successfully modeled. PMID: 28817220
    4. the cell surface expression of HAI-1 in all viable epidermal layers renders it an effective regulator for matriptase and prostasin PMID: 29438412
    5. Data suggest that HAI1, a protease on the surface of colon carcinoma cells, is an MMP7 substrate; proteolysis by MMP7 releases extracellular region as soluble HAI1 (sHAI1); sHAI1 induces cancer cell aggregation; cholesterol sulfate is required for MMP-7--catalyzed generation of sHAI1. (HAI1 = hepatocyte growth factor activator inhibitor type 1; MMP7 = matrix metalloproteinase-7) PMID: 29046355
    6. Concomitant presence of TMPRSS13 with HAI-1 mediates phosphorylation of residues in the intracellular domain of the protease, and it coincides with efficient transport of the protease to the cell surface and its subsequent shedding. PMID: 28710277
    7. our data illustrated a novel pathway comprising miR-221and miR-222 and hepatocyte growth factor activator inhibitor type 1 in gastric cancer, which is a potential target for future clinical use PMID: 28618968
    8. DNA methylation levels in the COASY and SPINT1 promoter regions were considered to potentially be a convenient and useful biomarker for diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment. PMID: 27992572
    9. The structural insights gained here improve our understanding of the regulation of HAI-1 inhibitory activities and point to new approaches for better controlling these activities. PMID: 28348076
    10. The present study demonstrated that ovarian cancer cell metastasis and invasion were more dependent on upregulation of matriptase levels than downregulation of HAI1. Matriptase may be a potential adjuvant therapeutic target for inhibiting ovarian cancer invasion and metastasis. PMID: 27356668
    11. provide new insight into the interplay between tertiary structure and the inhibitory activity of a multidomain protease inhibitor PMID: 27226587
    12. The findings suggest that the oncogenic activity of hepsin arises not only from elevated expression level but also from depletion of HAI-1, events which together trigger gain-of-function activity impacting HGF/MET signalling and epithelial cohesion PMID: 26165838
    13. it was found that the recombinant fusion protein uPA17-34-KPI (kunitz-type protease inhibitor ) inhibited the invasion and metastasis of ovarian tumors PMID: 26166362
    14. HAI-1 may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2-dependent p38 mitogen-activated protein kinase signaling. PMID: 25842366
    15. the anti-migratory effects seen via gamma-catenin were driven by the expression of hepatocyte growth factor activator inhibitor Type I (HAI-1 or SPINT-1), an upstream inhibitor of the c-MET signaling pathway. PMID: 25925948
    16. Data suggest HAI1 exhibits structural features consistent with classification in MANEC subclass of PAN/apple domain family with unifying features such as two additional disulfide bonds, two extended loop regions, and additional alpha-helical elements. PMID: 25510835
    17. Matriptase activity was suppressed by the expression of HAI-1. PMID: 24147538
    18. The results of the present study identified HAI-1 as a favorable prognostic marker for prostate cancer and may indicate that HAI-1 could be a therapeutic target for the treatment of this malignancy. PMID: 24659667
    19. HAI-1 expression correlates with the differentiation status of colorectal epithelia and could serve as a differentiation marker. PMID: 23979832
    20. HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP sign PMID: 23409135
    21. Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1 PMID: 23443661
    22. It is suggested that HAI-1 may play an important role in the pathogenesis of castration-resistant prostate cancer PMID: 23393351
    23. These results suggest that HAI-1 functions as a physiological regulator of HAT by inhibiting its protease activity and proteolytic activation in airway epithelium.(HAI-1) PMID: 22023801
    24. we showed for the first time that MT1-MMP activates matriptase through the cleavage of HAI-1 PMID: 22118498
    25. These data suggest that matriptase activity can be rapidly inhibited by HAI-1 and other HAI-1-like protease inhibitors and "locked" in an inactive autoactivation intermediate, all of which places matriptase under very tight control. PMID: 22031598
    26. HAI-1 and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation. PMID: 21898507
    27. The data suggested that normal epithelial cells use a dual mechanism involving hepatocyte growth factor activator inhibitor-1 and antithrombin to control matriptase and that the antithrombin-based mechanism is lost in the majority of carcinomas. PMID: 21795523
    28. Low HAI-1 is associated with endometrial cancer. PMID: 20715109
    29. High-level expression of HAI-1 is retained in the epidermal granular layer. This pattern of expression is retained in most skin disorders. PMID: 21123732
    30. Expression of HAI-1 in hepatocellular carcinoma is associated with poor prognosis. HAI-1 may be important in neoplasm progression and a new prognostic factor for hepatocellular carcinoma. PMID: 20213201
    31. HAI-1 regulates pulmonary metastasis of the human pancreatic carcinoma cell line SUIT-2 PMID: 21166957
    32. results suggest that TMPRSS13 functions as an HGF-converting protease, the activity of which may be regulated by HAI-1 PMID: 20977675
    33. the matriptase-prostasin proteolytic cascade is tightly regulated by two mechanisms: 1) prostasin activation temporally coupled to matriptase autoactivation and 2) HAI-1 rapidly inhibiting not only active matriptase but also active prostasin PMID: 20696767
    34. Data suggest that over-expression of HAI-1 in SW620 cells has weak effect on cell growth in vitro, but can significantly inhibit cell migration/motility. PMID: 16044910
    35. hepatocyte growth factor activator inhibitor-1B (new isoform) has roles in various physiological and pathological processes PMID: 12815039
    36. 1 serine protease inhibitor genotype is a significant risk factor for chronic obstructive pulmonary disease. PMID: 15994391
    37. HAI-1B is a potential physiological regulator of prostasin function PMID: 16103126
    38. The expressions of SNC19/matriptase and its inhibitor HAI-1 are decreased in gastrointestinal cancer tissues PMID: 16273651
    39. results show that dysregulation of the matriptase/HAI-1 mRNA ratio occurs early during colorectal cancer carcinogenesis PMID: 16820046
    40. Addition of HAI1 blocked the proteolytic activation of STP14 at the cell surface of peritoneal macrophages. PMID: 17389401
    41. Prostate cancer cells, after loss of HAI-1, had a significantly increased in vitro invasiveness together with an increase in cellular motility. PMID: 17786295
    42. analysis of the regulation of matriptase and HAI-1 with an emphasis on the molecular mechanisms governing its zymogen activation, inhibition by HAI-1, and ectodomain shedding [review] PMID: 17981575
    43. Unlike HAI-1 and matriptase, HAI-2 expression is detected in non-epithelial cells of brain and lymph nodes, suggesting that HAI-2 may also be involved in inhibition of serine proteases other than matriptase PMID: 18713750
    44. tissue microenvironment regulates the cell surface expression of HAI-1, and thereby may regulate proteolysis and processing of bioactive molecules on the cellular surface PMID: 18769935
    45. HAI-1 expression levels were significantly higher in all proliferative prostate diseases and seems to be a marker of prostate epithelial cell proliferation PMID: 18813126
    46. HAI-1 and HAI-2 may possibly be therapeutic target for treatment approaches in ovarian cancer. PMID: 19148468
    47. Expression of hepatocyte growth factor activator inhibitor type 1 in bronchial epithelial cells are altered by tissue injury to bronchi. PMID: 19222607
    48. interactions between HAI-1/SPINT1 and membrane-bound serine proteinases contribute to transcriptional and functional changes involved in EMT in certain carcinoma cells. PMID: 19223533
    49. Data suggest that the cellular location of matriptase activation and inhibition, and the secretory route for matriptase-HAI-1 complex may vary along with the functional divergence of different epithelial cells. PMID: 19535514
    50. The disease-free and overall survival rates of patients exhibiting high HAI-1 expression were significantly higher than those of patients exhibiting low HAI-1 expression in cervix cancer. PMID: 19578736

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  • 亞細胞定位:
    Secreted.
  • 數據庫鏈接:

    HGNC: 11246

    OMIM: 605123

    KEGG: hsa:6692

    STRING: 9606.ENSP00000342098

    UniGene: Hs.233950



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