在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SPIN1 Antibody

  • 中文名稱:
    SPIN1兔多克隆抗體
  • 貨號:
    CSB-PA897305DSR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: SPIN1 antibody at 1.45µg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: 293T whole cell lysate
      Lane 3: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 30 kDa
      Observed band size: 30 kDa
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA897305DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA897305DSR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SPIN1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    OCR antibody; Ovarian cancer-related protein antibody; SPIN antibody; Spin1 antibody; SPIN1_HUMAN antibody; Spindlin-1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Spindlin-1 protein (1-262AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway. Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes. May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption.
  • 基因功能參考文獻:
    1. identified SPIN.DOC as a transcriptional repressor that binds SPIN1 and masks its ability to engage the H3-Lys-4 trimethylation activation mark PMID: 29061846
    2. we describe the first example of a histone code reader controlling SkM development in mice, which hints at Spin1 as a potential player in human SkM disease. PMID: 29168801
    3. miR-489 loss facilitates malignant phenotype of glioma cells probably via SPIN1-mediated PI3K/AKT pathway. PMID: 28666210
    4. In triple negative breast cancer (TNBC) cells the simultaneous miR-29b-1-5p down regulation and SPIN1 up-regulation can potentially be associated with TNBC malignancy. PMID: 28423652
    5. These data indicate that miR-489 could reverse the chemoresistance of breast cancer via the PI3K-Akt pathway by targeting SPIN1. PMID: 27171498
    6. High SPIN1 expression is associated with liposarcoma. PMID: 25749382
    7. Spindlin1 activates Wnt/beta-catenin signaling downstream from protein arginine methyltransferase 2 (PRMT2) and the MLL complex, which together are capable of generating a specific H3 "K4me3-R8me2a" pattern. PMID: 24589551
    8. the histone sequence is recognized in a distinct manner involving the amino terminus and a pair of arginine residues of histone H3, and disruption of the binding impaired stimulation of pre-RNA expression by Spindlin1 PMID: 23077255
    9. SPINDLIN1, which may be a novel substrate of the Aurora-A kinase, promotes cancer cell growth through WNT/TCF-4 signaling activation. PMID: 22258766
    10. Spindlin1 localizes to the active ribosomal DNA (rDNA) repeats, and Spindlin1 facilitates the expression of ribosomal RNA genes. PMID: 21960006
    11. spindlin1 gene may contribute to tumorigenesis PMID: 16098913
    12. recombinant human spindlin1 has been overexpressed in Escherichia coli BL21, purified and crystallized using the hanging-drop vapour-diffusion method PMID: 16472086
    13. analysis of human spindlin1 tudor-like domains for cell cycle regulation PMID: 17082182
    14. SPINDLIN1 is an important gene for mammalian mitotic chromosome functions, and disrupted regulation results in abnormal cell division, a mechanism that may be involved in tumorigenesis PMID: 18201843
    15. Excess spindlin1 protein may be detrimental for spindle microtubule organization, chromosomal stability and can potentially contribute to the development of cancer. PMID: 18543248

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Nucleus, nucleolus.
  • 蛋白家族:
    SPIN/STSY family
  • 組織特異性:
    Highly expressed in ovarian cancer tissues.
  • 數據庫鏈接:

    HGNC: 11243

    OMIM: 609936

    KEGG: hsa:10927

    STRING: 9606.ENSP00000365019

    UniGene: Hs.146804



主站蜘蛛池模板: 亚洲暴爽av天天爽日日碰| 青青草av国产精品| 老熟妇乱子伦牲交视频| а天堂中文最新一区二区三区| 人妻夜夜爽天天爽三区丁香花| 婷婷久久综合九色综合绿巨人| 白嫩无码人妻丰满熟妇啪啪区百度| 国产成 人 综合 亚洲网站| 任我爽橹在线精品视频| 亚洲精品国产精品乱码不卡√| 久久无码人妻一区二区三区| 精品性高朝久久久久久久| 日本国产网曝视频在线观看 | 久久婷婷色综合一区二区| 丰满人妻一区二区三区无码av| 国产在线一区二区在线视频 | 日本中文字幕有码在线视频| 性一交一无一伦一精一品| 精品偷拍被偷拍在线观看| 野外做受又硬又粗又大视幕| 欧美极品少妇无套实战| 中国女人和老外的毛片 | 久久久久se色偷偷亚洲精品av| 国产成人精品久久一区二区三区 | 最新中文乱码字字幕在线| 国产真实乱人偷精品人妻| 亚洲成av人在线播放无码| 免费看女人与善牲交| 国产免费一区二区三区不卡| 国产 亚洲 制服 无码 中文| 国产无遮挡又黄又爽又色| 青青青青国产免费线在线观看| 97se亚洲国产综合自在线 | 人妻丰满熟妇岳av无码区hd | 亚洲精品第一国产综合境外资源| 最新国产久免费视频在线观看 | 亚洲精品国产一区二区在线观看 | 成人艳情一二三区| 蜜臀亚洲精品国产aⅴ综合第一| 国产免费又色又爽又黄软件| 99国精品午夜福利视频不卡 |