在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SPG20 Antibody

  • 中文名稱:
    SPG20兔多克隆抗體
  • 貨號:
    CSB-PA022542GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    SPART antibody; KIAA0610 antibody; SPG20 antibody; TAHCCP1 antibody; Spartin antibody; Spastic paraplegia 20 protein antibody; Trans-activated by hepatitis C virus core protein 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human SPG20
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis.
  • 基因功能參考文獻:
    1. Methylation-induced Spastic paraplegia 20 silencing facilitates gastric cancer cell proliferation by activating the EGFR/MAPK signaling pathway. PMID: 29673586
    2. we report the clinical findings in three brothers of a consanguineous Moroccan family, aged 24, 17, and 7 yr old, with spastic paraplegia, short stature, motor and cognitive delay, and severe intellectual disability. Targeted exon capture and sequencing showed a homozygous nonsense mutation in the SPG20 gene, c.1369C>T (p.Arg457*), in the three affected boys. PMID: 28679690
    3. Study identified mutation in SPG20 as the disease causing mutation for Troyer Syndrome in Turkish siblings. PMID: 26003402
    4. Up-regulation of SPG20 expression, brought about by trisomy 13 in colon cancer cells trisomy 13 amniocytes, is sufficient for the cytokinesis failure phenotype. PMID: 25942454
    5. hypermethylation of the spastic paraplegia-20 promoter occurred frequently in gastric cancer. PMID: 24381142
    6. The study reveals that hypermethylation in Spastic paraplegia-20 promoter is a highly specific and sensitive biomarker for screening colorectal cancer in stool samples as a noninvasive method. PMID: 23372428
    7. Spartin regulates both synaptic development and neuronal survival by controlling microtubule stability via the BMP-Drosophila fragile X mental retardation protein-Futsch pathway. PMID: 23439121
    8. SPG20 protein spartin associates with cardiolipin via its plant-related senescence domain and regulates mitochondrial Ca2+ homeostasis PMID: 21559443
    9. The present study identifies SPG20 promoter hypermethylation as a biomarker suitable for non-invasive detection of colorectal cancer, and a possible mechanism for cytokinesis arrest in colorectal tumorigenesis. PMID: 21499309
    10. These data suggest that Ist1 interaction is important for spartin recruitment to the midbody and that spartin participates in cytokinesis. PMID: 20719964
    11. Spartin acts as an adaptor protein that activates and recruits AIP4 E3 ubiquitin ligase to lipid droplets and by this means regulates the level of ubiquitination of adipophilin. PMID: 20504295
    12. SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia.We report mapping of the TRS locus to chromosome 13q12.3 and identify a frameshift mutation in SPG20, encoding spartin PMID: 12134148
    13. Our results suggest that spartin might be involved in endocytosis, vesicle trafficking, or mitogenic activity, and that impairment in one of these processes may underlie the long axonopathy in patients with Troyer syndrome. PMID: 16036216
    14. This study provides the first evidence of spartin subcellular localization and identifies it as the third mitochondrial protein implicated in hereditary spastic paraplegia. PMID: 16945107
    15. overexpression of spartin results in a prominent decrease in EGFR degradation PMID: 17332501
    16. We describe a new family with Troyer syndrome due to the 1110delA mutation. PMID: 18413476
    17. experiments suggest functions for ubiquitin ligases and SPG20 in the regulation of lipid droplet turnover and potential pathological mechanisms in Troyer syndrome. PMID: 19307600
    18. SPG20 interacts with endosomes and AIP4 and AIP5. PMID: 19580544
    19. The hereditary spastic paraplegia proteins NIPA1, spastin and spartin inhibit BMP signalling by promoting BMP receptors degradation. PMID: 19620182

    顯示更多

    收起更多

  • 相關疾病:
    Spastic paraplegia 20, autosomal recessive (SPG20)
  • 亞細胞定位:
    Cytoplasm. Midbody.
  • 組織特異性:
    Ubiquitously expressed, with highest levels of expression detected in adipose tissue.
  • 數據庫鏈接:

    HGNC: 18514

    OMIM: 275900

    KEGG: hsa:23111

    STRING: 9606.ENSP00000347314

    UniGene: Hs.440414



主站蜘蛛池模板: 国产精品美女久久久久久久 | 亚洲已满18点击进入在线看片| 亚洲爆乳无码一区二区三区| 色婷婷我要去我去也| 国产v亚洲v天堂a无码99| 国产亚洲精品在av| 国模小黎自慰gogo人体| 亚洲国产日韩欧美一区二区三区| 亚洲人成网站在线播放影院在线 | 成人无码一区二区三区网站 | 国产在线码观看清码视频| 老子影院午夜伦不卡无码| 国产亚av手机在线观看| 久久久久国产综合av天堂| 日韩在线永久免费播放| 无码中文字幕波多野结衣| 少妇富婆高级按摩出水高潮| 亚洲精品国产一区二区精华液| 日韩精品无码一区二区中文字幕 | 人人妻在人人| 亚洲αv无码一区二区三区四区| 99久久国产亚洲高清观看| 久青青视频在线观看久| 国产精品亚洲αv天堂无码| 色猫咪av在线观看| 精品无码久久久久国产电影| 亚洲 欧美 唯美 国产 伦 综合| 99久热在线精品996热是什么| 大肉大捧一进一出好爽动态图 | 亚洲国产欧美日韩精品一区二区三区 | 4399理论片午午伦夜理片| 999国产精品999久久久久久| 天堂а√在线最新版中文| 国产婷婷丁香五月缴情成人网| 久久国产精品无码网站| 日日躁夜夜躁狠狠躁超碰97| 成年片色大黄全免费软件到| 国产精品无需播放器在线观看| 麻豆传传媒久久久爱| 国产性猛交╳xxx乱大交| 国产美女被遭高潮免费网站|