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SPC24 Antibody, HRP conjugated

  • 中文名稱：
    SPC24兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA836712LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SPC24 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SPC24
  • 別名：
    FLJ90806 antibody; hSpc24 antibody; Kinetochore protein Spc24 antibody; SPBC24 antibody; spc24 antibody; SPC24 NDC80 kinetochore complex component antibody; SPC24 NDC80 kinetochore complex component homolog antibody; SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) antibody; SPC24_HUMAN antibody; Spindle pole body component 24 homolog (S. cerevisiae) antibody; Spindle pole body component 24 homolog antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Kinetochore protein Spc24 protein (21-97AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules.
  • 基因功能參考文獻：
    1. SPC24 is up-regulated in human breast cancer.SPC24 regulates PI3K/AKT kinase pathway in breast cancer. PMID: 30180968
    2. our data demonstrates that SPC24 can serve as a promising prognostic biomarker of anaplastic thyroid cancer cells PMID: 28423533
    3. Data indicate that kinetochore protein Spc24 (SPC24) may be a promising molecular target for hepatocellular carcinoma (HCC) therapy. PMID: 26515591
    4. hSPC24 is a component of the human NDC80 kinetochore complex PMID: 14699129
  • 亞細胞定位：
    Nucleus. Chromosome, centromere, kinetochore.
  • 蛋白家族：
    SPC24 family
  • 數據庫鏈接：

    HGNC: 26913

    OMIM: 609394

    KEGG: hsa:147841

    STRING: 9606.ENSP00000465075

    UniGene: Hs.381225



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