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  4. SPATA16 Antibody

SPATA16 Antibody

  • 中文名稱：
    SPATA16兔多克隆抗體
  • 貨號：
    CSB-PA275207
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA275207(SPATA16 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA275207(SPATA16 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 12%SDS-PAGE, Lysate: 50 μg, Lane: Human liver cancer tissue, Primary antibody: CSB-PA275207(SPATA16 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SPATA16
  • 別名：
    NYD SP12 antibody; NYD-SP12 antibody; NYDSP12 antibody; SPATA16 antibody; Spermatogenesis associated 16 antibody; Spermatogenesis-associated protein 16 antibody; SPGF6 antibody; SPT16_HUMAN antibody; Testis development protein antibody; Testis development protein NYD-SP12 antibody; Testis specific Golgi protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human SPATA16
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:15-1:50
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion.
  • 基因功能參考文獻：
    1. This study demonstrates that Spata16 is indispensable for male fertility in mice, as well as in humans. PMID: 29065458
    2. Mutation of SPATA16 is associated with globozoospermia. PMID: 27086357
    3. Case Report: report of a pregnancy obtained in a man with homozygous SPATA16 mutated globozoospermia. PMID: 24825417
    4. results suggest that NYD-SP12 is involved in spermatogenesis, and that NYD-SP12-encoded protein might function in the Golgi apparatus PMID: 12529416
    5. study demonstrated NYD-SP12 protein was involved in the formation of the acrosome during spermatogenesis PMID: 16372119
    6. Results indicate that NYD-SP12 evolves rapidly in both the human and the chimpanzee lineages, which is likely caused by Darwinian positive selection and/or sexual selection. PMID: 17665087
    7. consanguineous family with three affected brothers, in whom we have identified a homozygous mutation in the spermatogenesis-specific gene SPATA16. This is the first example of a nonsyndromic male infertility condition caused by an autosomal gene defect. PMID: 17847006

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  • 相關疾病：
    Spermatogenic failure 6 (SPGF6)
  • 亞細胞定位：
    Golgi apparatus. Note=Localized to the perinuclear region.
  • 蛋白家族：
    SPATA16 family
  • 組織特異性：
    Expressed in testis.
  • 數據庫鏈接：

    HGNC: 29935

    OMIM: 102530

    KEGG: hsa:83893

    STRING: 9606.ENSP00000341765

    UniGene: Hs.444236



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