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  4. SPAG8 Antibody

SPAG8 Antibody

  • 中文名稱：
    SPAG8兔多克隆抗體
  • 貨號：
    CSB-PA209919
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA209919(SPAG8 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SPAG8
  • 別名：
    BS 84 antibody; CILD28 antibody; HSD 1 antibody; HSD-1 antibody; HSD1 antibody; hSMP1 antibody; MGC26201 antibody; MH SPAG8 antibody; OTTHUMP00000021352 antibody; OTTMUSP00000032209 antibody; SMP-1 antibody; SMP1 antibody; SPAG3 antibody; SPAG8 antibody; SPAG8_HUMAN antibody; Sperm associated antigen 8 antibody; Sperm associated antigen 8 like protein antibody; Sperm membrane protein 1 antibody; Sperm membrane protein BS-84 antibody; Sperm-associated antigen 8 antibody; Testicular tissue protein Li 177 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Fusion protein of Human SPAG8
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau. Involved in the acrosome reaction and in binding of sperm to the zona pellucida. Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis. May play a role in fertility and microtubule formation through interaction with RANBP9.
  • 基因功能參考文獻：
    1. Results indicate that SPAG8 acts as a regulator of ACT and plays an important role in CREM-ACT-mediated gene transcription during spermatogenesis. PMID: 20488182
    2. The antibody of this recombinant protein inhibits the mouse acrosome reaction and prmits mouse sperm-zona pellucida binding. PMID: 17187156
    3. Sperm associated antigen 8 might be involved in the regulation of cell cycle by changing the phosphorylation level of Tyr15 on CDC2 Protein Kinase. PMID: 19548270
  • 亞細胞定位：
    Cytoplasm. Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome. Cytoplasm, cytoskeleton, microtubule organizing center. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族：
    SPAG8 family
  • 組織特異性：
    Expressed in testis (germ cells), but not in liver, kidney, prostate and small intestine.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14105

    OMIM: 605731

    KEGG: hsa:26206

    STRING: 9606.ENSP00000340982

    UniGene: Hs.256747



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