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SPAG16 Antibody

  • 中文名稱：
    SPAG16兔多克隆抗體
  • 貨號：
    CSB-PA818674ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA818674ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA818674ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SPAG16 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SPAG16
  • 別名：
    SPAG16 antibody; PF20 antibody; Sperm-associated antigen 16 protein antibody; Pf20 protein homolog antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Sperm-associated antigen 16 protein (1-183AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia.
  • 基因功能參考文獻：
    1. Short-SOX5 regulates transcription of human SPAG16L gene via directly binding to the promoter of SPAG16L. PMID: 28137312
    2. SPAG16 is a novel autoantibody target in a subgroup of MS patients and in combination with other diagnostic criteria, elevated levels of anti-SPAG16 Abs could be used as a biomarker for diagnosis. PMID: 25086173
    3. SPAG16 influences MMP-3 regulation and protects against joint destruction in autoantibody-positive rheumatoid arthritis. PMID: 23956247
    4. Analysis of SPAG16 regions encoding conserved WD repeats revealed no evidence for association of mutations or genetic variation with sperm motility in infertile males. PMID: 22963137
    5. Data describe the cloning of human and mouse Pf20 proteins that interact with Spag6 protein. PMID: 12391165
    6. Heterozygous mutation that affects both SPAG16L and SPAG16S does not cause male infertility in man, but is associated with reduced stability of the interacting proteins of the central apparatus. PMID: 17699735

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  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, flagellum axoneme. Cytoplasm, cytoskeleton, cilium axoneme. Cell projection, cilium, flagellum.
  • 組織特異性：
    Isoform 1 is detected in testis. Isoform 4 is detected in testis and brain, and at lower levels in kidney, heart, pancreas, thyroid, ovary, adrenal gland, spinal cord, trachea and liver.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23225

    OMIM: 612173

    KEGG: hsa:79582

    STRING: 9606.ENSP00000332592

    UniGene: Hs.743365



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