在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SP100 Antibody

SP100 Antibody

  • 中文名稱：
    SP100兔多克隆抗體
  • 貨號：
    CSB-PA022439GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SP100
  • 別名：
    DKFZp686E07254 antibody; FLJ00340 antibody; FLJ34579 antibody; Lysp100b antibody; Nuclear antigen Sp100 antibody; Nuclear autoantigen Sp 100 antibody; Nuclear autoantigen Sp-100 antibody; Nuclear autoantigen Sp100 antibody; Nuclear dot associated Sp100 protein antibody; Nuclear dot-associated Sp100 protein antibody; SP 100 antibody; SP100 antibody; SP100 HMG nuclear autoantigen antibody; SP100 nuclear antigen antibody; SP100_HUMAN antibody; Speckled 100 kDa antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Human SP100
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.
  • 基因功能參考文獻：
    1. the ND10 bodies become viral replication compartments, and ICP0, a viral E3 ligase, degrades both PML and SP100. The amounts of PML and SP100 and the number of ND10 structures increase in cells exposed to IFN-beta. PMID: 28439026
    2. that Sp100 represses viral transcription and replication in differentiated cells PMID: 28968443
    3. Data suggest that nuclear antigen Sp100C is a multifaceted histone H3 methylation and phosphorylation sensor. PMID: 27129259
    4. These results suggest that high-risk human papillomavirus 31 target interferon kappa to prevent Sp100 expression and identify Sp100 as an interferon-stimulated gene with anti-human papillomavirus activity. PMID: 26491169
    5. PML, hDaxx and Sp100 primarily act as cellular restriction factors during lytic human cytomegalovirus replication and during the dynamic process of reactivation but do not serve as key determinants for the establishment of latency. PMID: 26057166
    6. Sp100 repressed viral transcription and replication only during the initial stages of viral establishment, suggesting that Sp100 acts as a repressor of incoming human papillomavirus type 18 DNA. PMID: 24194542
    7. Sp100 depletion promotes Adenovirus progeny production and early viral protein synthesis. PMID: 24623443
    8. Two regions within the N-terminal of the herpes simplex virus 1 ICP0 facilitate the degradation and dissociation of host PML and dissociation of Sp100 from ND10. PMID: 24089549
    9. Sp100 is recruited to activated arrays in cells expressing the herpes simplex virus type 1 E3 ubiquitin ligase, ICP0, which degrades all Sp100 isoforms except unsumoylated Sp100A. PMID: 23485562
    10. The results suggest that hantavirus infection interferes with DAXX-mediated apoptosis, and expression of interferon-activated Sp100 and ISG-20 proteins may indicate intracellular intrinsic antiviral attempts. PMID: 23830076
    11. SP100 and Adeno-associated virus 2 Rep78 are both located in the nucleolus, which provides the spatial possibility for their interaction. PMID: 22419217
    12. Authors conclude that several ND10 components, including Daxx, the promyelocytic leukemia (PML) protein, and Sp100 cooperate in an additive manner to regulate herpes simplex virus type 1 and human cytomegalovirus infection. PMID: 23221561
    13. Herpesvirus saimiri tegument protein specifically degraded the cellular ND10 component Sp100. PMID: 22278248
    14. These findings expand our knowledge of both Sp100 and Cdc20 as well as their role in ubiquitination. PMID: 22086178
    15. These findings indicate that thehuman herpesvirus 5 IE1-dependent loss of human Sp100 proteins during virus infection may represent an important requirement for efficient viral growth. PMID: 21880768
    16. Taken together, these data provide evidence that Sp100 is the first ND10-related factor identified that not only possesses the potential to restrict the initial stage of infection but also inhibits cytomegalovirus replication during the late phase. PMID: 21734036
    17. Sp100 counteract human cytomegalovirus infection via the repression of viral immediate-early gene expression. PMID: 21471311
    18. SP100 expression reduces malignancy of brain tumors PMID: 21274506
    19. Endogenous Sp100 may interact with PhiC31 integrase and inhibit the efficiency of PhiC31 integrase-mediated recombination. PMID: 21383994
    20. Sp100 has a role in the initiation and progression of tumorgenesis PMID: 20512085
    21. During interphase PML-NBs adopt a spherical organization characterized by the assembly of PML and Sp100 proteins into patches within a 50- to 100-nm-thick shell. PMID: 20130140
    22. Sp100 interacts with ETS-1 and stimulates its transcriptional activity. PMID: 11909962
    23. a novel function for Sp100 as a coactivator for HIPK2-mediated p53 activation. PMID: 14647468
    24. SP100 modulates ETS1-dependent biological processes PMID: 15247905
    25. Genes that are negatively regulated by ETS1 and upregulated by SP100 have antimigratory or antiangiogenic properties. PMID: 15592518
    26. EBNA-LP interacts with the promyelocytic leukemia nuclear body (PML NB)-associated protein Sp100 and displaces Sp100 and heterochromatin protein 1alpha (HP1alpha) from PML NBs. PMID: 16177824
    27. Repressive Sp100 isoforms B, C, and HMG are an essential part of the IFN-beta-mediated suppression of ICP0 expression. PMID: 16873258
    28. Sp100 isoforms suppress immediate-early HSV-1 proteins at the promoter level and that IFN changes the splicing pattern of the Sp100 transcript to the suppressing Sp100C isoform. PMID: 19279115

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Nucleus, PML body. Cytoplasm. Note=Differences in the subnuclear localization of the different isoforms seem to exist and may also be cell cycle- and interferon-dependent. Accumulates in the cytoplasm upon FAS activation.; [Isoform Sp100-C]: Nucleus. Note=Forms a reticulate or track-like nuclear pattern with denser concentrations at the nuclear lamina and surrounding the nucleoli, a pattern reminiscent of heterochromatin-rich regions according to PubMed:11313457.
  • 組織特異性：
    Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines.
  • 數據庫鏈接：

    HGNC: 11206

    OMIM: 604585

    KEGG: hsa:6672

    STRING: 9606.ENSP00000343023

    UniGene: Hs.369056



主站蜘蛛池模板： 久久精品国产亚洲一区二区| 日日摸日日碰夜夜爽av| 草裙社区精品视频三区免费看| 国产女人叫床高潮大片| 国产在线精品二区| 天堂网在线最新版www资源网| 国产成人av免费网址| 国语自产视频在线| 亚洲精品久久久久久中文传媒| 国产人妻精品久久久久野外| 人妻激情偷乱一区二区三区| 2020精品国产视| 久久精品伊人久久精品伊人| 亚洲国产精品热久久| 国产99久一区二区三区a片| 国产高清不卡免费视频| 综合亚洲桃色第一影院| 美女裸体无遮挡免费视频网站| 亚洲精品久久午夜无码一区二区 | 色播久久人人爽人人爽人人片av| 久久婷婷激情综合色综合俺也去 | 午夜爽爽爽男女免费观看麻豆国产| 久久国产成人精品av| 国产96在线 | 欧美| 四房播色综合久久婷婷| 久爱www人成免费网站| 琪琪午夜伦埋影院77| 国产成人无码网站| 亚洲伊人久久综合成人| 无码一卡二卡三卡四卡| 扒开女人内裤猛进猛出免费视频| 欧美亚洲一区二区三区| 国产精品69人妻无码久久| 丰满少妇人妻无码| 99久久久无码国产精品性| 欧美成aⅴ人高清怡红院| 大伊香蕉精品视频在线直播| 国产精品 视频一区 二区三区| av片在线观看免费| 四虎影在永久在线观看| √天堂资源在线中文8在线最新版|