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SOS2 Antibody, FITC conjugated

  • 中文名稱:
    SOS2兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA22327C0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SOS2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    FLJ25596 antibody; Guanine nucleotide exchange factor antibody; Guanine nucleotide releasing factor antibody; Son of sevenless (Drosophilia) homolog 2 antibody; Son of sevenless homolog 2 (Drosophila) antibody; Son of sevenless homolog 2 antibody; SOS 2 antibody; SOS-2 antibody; Sos2 antibody; SOS2_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Son of sevenless homolog 2 protein (187-404AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Promotes the exchange of Ras-bound GDP by GTP.
  • 基因功能參考文獻:
    1. Activating Mutations Affecting the Dbl Homology Domain of SOS2 Cause Noonan Syndrome PMID: 26173643
    2. We identified two novel genes, SOS2 and LZTR1, associated with Noonan syndrome, thereby expanding the molecular spectrum of RASopathies. PMID: 25795793
    3. multicenter pharmacogenetic study in children (ages 6-11): Data suggest that SNP in SOS2 (rs13379306) in children with growth hormone deficiency is associated with drug resistance to hormone replacement therapy with recombinant human growth hormone. PMID: 23761422
    4. intracellular Francisella tularensis novicida triggers temporal and early activation of Ras through the SOS2/GrB2/PKCalpha/PKCbetaI quaternary complex; Ras signalling by intracellular F. tularensis is essential for intracellular proliferation in the cytosol PMID: 20618341
    5. Significant association of single nucleotide polymorphism within three genes--PPARgamma, SOS2, and PCK1--with Alzheimer's disease, was confirmed. PMID: 17440948

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  • 相關疾病:
    Noonan syndrome 9 (NS9)
  • 數據庫鏈接:

    HGNC: 11188

    OMIM: 601247

    KEGG: hsa:6655

    STRING: 9606.ENSP00000216373

    UniGene: Hs.291533



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