在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SOCS6 Antibody

SOCS6 Antibody

  • 中文名稱：
    SOCS6兔多克隆抗體
  • 貨號：
    CSB-PA795855
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA795855(SOCS6 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA795855(SOCS6 Antibody) at dilution 1/35, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: jurkat cells, Primary antibody: CSB-PA795855(SOCS6 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CIS-4 antibody; CIS4 antibody; Cish4 antibody; Cytokine inducible SH2 protein 4 antibody; Cytokine-inducible SH2 protein 4 antibody; HSPC060 antibody; SOCS-4 antibody; SOCS-6 antibody; SOCS4 antibody; Socs6 antibody; SOCS6_HUMAN antibody; SSI4 antibody; STAI4 antibody; STAT induced STAT inhibitor 4 antibody; STAT4 antibody; STATI4 antibody; Suppressor of cytokine signaling 4 antibody; Suppressor of cytokine signaling 6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human SOCS6
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.
  • 基因功能參考文獻：
    1. Together, our data provide important evidence for miR-19 mediated SOCS6 in OS growth and revealed miR-19/SOCS6/JAK2/STAT3 pathway as a potential therapeutic strategy for OS patients. PMID: 28986253
    2. Results indicate that similar to PTEN pseudogene (PTENP1), suppressor of cytokine signaling 6 protein (SOCS6) expression was also significantly lower in esophageal squamous cell carcinoma (ESCC) samples. PMID: 28731203
    3. our results describe for the first time the role of miR-494-3p during normal hematopoietic stem/progenitor cells differentiation and suggest that its increased expression, and the subsequent downregulation of its target SOCS6, might contribute to the megakaryocyte hyperplasia commonly observed in primary myelofibrosis patients. PMID: 28423484
    4. miR-142-3p regulates NPC development by down-regulating SOCS6 expression and suggest that modulation of miR-142-3p expression could be a therapeutic strategy for NPC PMID: 26183850
    5. Studied both the function of upregulated miR-424-5p in pancreatic cancer and how downstream suppressor of cytokine-induced signaling 6 (SOCS6) is negatively regulated by miR-424-5p. PMID: 23653113
    6. miR-17-5p might function as a pro-proliferative factor by repressing SOCS6 in gastric cancer PMID: 24801601
    7. Results show that SOCS6 forms complex with DRP1 and the mitochondrial phosphatase PGAM5, attenuates DRP1 phosphorylation, and promotes DRP1 mitochondrial translocation. PMID: 22955947
    8. SOCS6 negatively regulates Flt3 activation, the downstream Erk signaling pathway, and cell proliferation. PMID: 22952242
    9. Reduced copy number and mRNA expression of SOCS6 are associated with disease recurrence in primary lung squamous cell carcinoma and may be useful prognostic biomarkers. PMID: 22363434
    10. The results may contribute to understanding SOCS5 and SOCS6 expression regulation in various cancer tissues, and show that these two factors may be used for diagnosing cancer. PMID: 22081311
    11. SOCS6 has ubiquitin ligase activity toward c-KIT PMID: 21030588
    12. These results establish that SOCS-6 acts as a negative regulator of T cell activation by promoting ubiquitin-dependent proteolysis of p56(lck). PMID: 20007709
    13. Data support the importance of loss-of-function of SOCS6 as a frequent event in gastric tumorigenesis. PMID: 19646809
    14. HOIL-1 expression stabilizes SOCS6 and induces the ubiquitination and degradation of proteins associated with SOCS6 PMID: 16643902
    15. These observations suggest that Erk activation may be correlated in the cells with high expression of SOCS6. PMID: 17210122
    16. These observations suggest that SOCS6 is composed of at least two functional domains required for its biological role in localizing and degrading Stat3 in the nucleus. PMID: 17603019
    17. Study demonstrated that hypermethylation of the SOCS6 promoter is one of the mechanisms for the epigenetic regulation of SOCS6 expression. PMID: 19716864

    顯示更多

    收起更多

  • 數據庫鏈接：

    HGNC: 16833

    OMIM: 605118

    KEGG: hsa:9306

    STRING: 9606.ENSP00000381034

    UniGene: Hs.44439



主站蜘蛛池模板： 青青草99久久精品国产综合| 国产在线观看黄av免费| 亚洲欧美日韩一区在线观看| 亚洲国产精品日韩av不卡在线| 欧美变态另类刺激| 精品性影院一区二区三区内射| 色婷婷综合久久久久中文字幕| 99久久伊人精品综合观看| 蜜臀久久99精品久久久久久做爰| 欧美大屁股xxxxhd黑色| 久久99精品国产99久久6不卡 | 伊人久久大香线蕉av网站| 国产精品成人国产乱| 嫩草伊人久久精品少妇av| 亚洲欧美日韩视频高清专区| 久久精品女人天堂av| 成人区人妻精品一区二区不卡网站| 午夜香蕉成视频人网站| 国产成人综合久久久久久| 日韩精品久久无码中文字幕| 爱久久av一区二区三区| 无码乱肉视频免费大全合集| 日韩精品一卡2卡三卡4卡| 日本高清视频在线www色| 撕开奶罩揉吃奶高潮av在线观看 | a毛片终身免费观看网站| 欧美日韩精品suv| 亚洲成色在线综合网站| 久久人人爽人人爽人人片亞洲 | 12裸体自慰免费观看网站| 国色天香成人网| 猫咪www免费人成人入口| 大伊香蕉精品一区二区 | 免费无遮挡无码永久在线观看视频 | 又粗又黄又硬又爽的免费视频| 99久久久无码国产精品9| 最新亚洲中文字幕在线观看| 天天爽夜夜爽人人爽从早干到睌| 亚洲国产精品综合久久网各| 无码av大香线蕉伊人久久 | 日韩人妻无码制服丝袜视频|