SNUPN Antibody

說明書

產品詳情

Uniprot No.：

O95149
基因名：

SNUPN
別名：

0610031A09Rik antibody; KPNBL antibody; MGC134006 antibody; MGC95000 antibody; RNA U transporter 1 antibody; RNA, U transporter 1 antibody; RNUT 1 antibody; RNUT1 antibody; SNUPN antibody; Snupn1 antibody; Snurportin 1 antibody; Snurportin-1 antibody; Snurportin1 antibody; SPN1 antibody; SPN1_HUMAN antibody; wu:fc41a03 antibody; zgc:77819 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human SNUPN
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC,IF
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
基因功能參考文獻：
1. Results show that marker rs218966 in gene PHF14 and rs9836027 in MAP4 significantly associated with hypertension; additionally, rare variants in SNUPN significantly associated with systolic blood pressure. PMID: 26866982
2. analysis of interactions between CRM1 and the nuclear pore protein Tpr and snurportin PMID: 24722547
3. SPN construct lacking the importin beta binding domain (IBB) localizes primarily to the nucleus rather than to the cytoplasm. PMID: 12095920
4. There is an interaction between the N- and C-terminal domains of SPN, suggesting an autoregulatory function similar to that of importin-alpha. PMID: 16030253
5. study presents the crystal structure of the SPN1.CRM1.RanGTP export complex at 2.5 angstrom resolution (where SPN1 is snurportin1 and RanGTP is guanosine 5' triphosphate-bound Ran PMID: 19389996
6. the binding of dimethylated RNA-caps to snurportin 1 PMID: 19619473
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亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

Snurportin family
數據庫鏈接：

HGNC: 14245

OMIM: 607902

KEGG: hsa:10073

STRING: 9606.ENSP00000309831

UniGene: Hs.21577

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