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  4. SNRPE Antibody, FITC conjugated

SNRPE Antibody, FITC conjugated

  • 中文名稱：
    SNRPE兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA022336LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SNRPE Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SNRPE
  • 別名：
    AL022645 antibody; B raf antibody; B-raf antibody; Braf antibody; C76690 antibody; HYPT11 antibody; RUXE_HUMAN antibody; Sm protein E antibody; Sm-E antibody; Small nuclear ribonucleoprotein E antibody; SmE antibody; snRNP-E antibody; snRNPE antibody; snrpe antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Small nuclear ribonucleoprotein E protein (1-92AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.
  • 基因功能參考文獻：
    1. Overexpression of SNRPE is associated with highly aggressive breast cancers. PMID: 23358685
    2. Mutations in SNRPE, which encodes a core protein of the spliceosome, cause autosomal-dominant hypotrichosis simplex PMID: 23246290
    3. In the SME intron, the position of the branchpoint A residue within the region base paired with U12 differs from that in P120 and XTF. PMID: 12022225
    4. growth arrest by SmE directly correlates with the reduction of cyclin E, CDK2, CDC25C and CDC2 expression, and up-regulation of p27Kip PMID: 18208561
  • 相關疾病：
    Hypotrichosis 11 (HYPT11)
  • 亞細胞定位：
    Cytoplasm, cytosol. Nucleus.
  • 蛋白家族：
    SnRNP Sm proteins family
  • 組織特異性：
    Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis.
  • 數據庫鏈接：

    HGNC: 11161

    OMIM: 128260

    KEGG: hsa:6635

    STRING: 9606.ENSP00000400591

    UniGene: Hs.334612



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