在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SNAPIN Antibody

SNAPIN Antibody

  • 中文名稱：
    SNAPIN兔多克隆抗體
  • 貨號：
    CSB-PA021882GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SNAPIN
  • 別名：
    OTTHUMP00000035157 antibody; SNAP associated protein antibody; SNAP-25-binding protein antibody; SNAP-associated protein antibody; SNAP25BP antibody; SNAPAP antibody; Snapin antibody; SNAPN_HUMAN antibody; SNARE associated protein snapin antibody; SNARE-associated protein Snapin antibody; Synaptosomal associated protein 25 binding protein antibody; Synaptosomal-associated protein 25-binding protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human SNAPIN
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor.
  • 基因功能參考文獻(xiàn)：
    1. These observations suggest an important role for SNAPIN and autophagy in the homeostasis of macrophages, particularly long-lived tissue resident macrophages. PMID: 27929705
    2. These results provide the evidence of a direct regulatory role of Snapin on Cav1.3 channels in atrial myocytes. PMID: 27915047
    3. Inhibition of Snapin enhanced localization of HIV-1 with TLR8(+) early endosomes, triggered a pro-inflammatory response, and inhibited trans-infection of CD4(+) T cells. PMID: 28923824
    4. Taken together, these results suggest that Snapin, the pUL130 interacting protein, has a role in modulating HCMV DNA synthesis. PMID: 27240978
    5. Disruption of Snapin-PKR2 interaction did not affect PKR2 signaling, but increased the ligand-induced degradation, implying a role of Snapin in the trafficking of PKR2. PMID: 26687946
    6. Authors propose that Snapin connects chlamydial inclusions with the microtubule network by interacting with both Chlamydia psittaci IncB and dynein. PMID: 24751478
    7. Snapin, a SNAP-25 (synaptosomal-associated protein-25) interacting protein, interacts with LRRK2. PMID: 23949442
    8. These observations identify Snapin as a novel endogenous TLR2 ligand in rheumatoid arthritis, and thus support a role for persistent TLR2 signalling in pathogenesis. PMID: 22523426
    9. These results suggest that Snapin may play a key role in regulating the cellular localization of human cytomegalovirus UL70, leading to modulation of viral DNA synthesis and progeny production. PMID: 21917956
    10. PKA-dependent phosphorylation of snapin increases interaction among insulin secretory vesicle-associated proteins, thereby potentiating glucose-stimulated insulin secretion. PMID: 21356520
    11. results suggest that RGS7 could play a role in synaptic vesicle exocytosis through its interaction with snapin PMID: 12659861
    12. EBAG9 and Snapin have roles in controlling exocytosis processes PMID: 15635093
    13. results demonstrate that snapin is a binding partner of dysbindin-1 in vitro and in the brain; both dysbindin-1 and snapin are concentrated in tissue enriched in synaptic vesicle membranes and less commonly in postsynaptic densities PMID: 16980328
    14. Snapin links the alpha(1A)-AR to TRPC6, augmenting Ca(2+) influx via ROC channels PMID: 17684020
    15. Data describe for the first time the expression of SNAPIN in germ cells which raises possibility that SNAPIN plays an extra role in mammals which is germ cell specific. PMID: 19168546
    16. Snapin plays an important role as a linker between the water channel and the t-SNARE complex, leading to the fusion event, and the pairing with specific t-SNAREs is essential for the specificity of membrane recognition and fusion. PMID: 19515809

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Golgi apparatus membrane. Lysosome membrane. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane.
  • 蛋白家族：
    SNAPIN family
  • 組織特異性：
    Expressed in male germ cells of adult testis (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17145

    OMIM: 607007

    KEGG: hsa:23557

    STRING: 9606.ENSP00000357674

    UniGene: Hs.32018



主站蜘蛛池模板： 青娱乐极品视觉盛宴国产视频| 狠狠躁18三区二区一区| 亚洲最新无码成av人| 最新的国产成人精品2021| 久久人人爽天天玩人人妻精品 | av中文无码乱人伦在线观看| 扒开双腿吃奶呻吟做受视频 | 欧美牲交a欧美牲交| 国产片av片永久免费观看| 少妇高潮喷水在线观看| 国产成人精品无码免费看夜聊软件| 精品一卡2卡3卡4卡新区在线| 日日碰狠狠躁久久躁2023| 亚洲欧美日韩在线不卡| 国产精品高清视亚洲中文| 老熟妇性老熟妇性色| 曰本大码熟中文字幕| 午夜精品久久久久久久爽 | 亚洲欧美国产成人综合欲网| 强奷乱码中文字幕熟女一| 成人免费乱码大片a毛片| 99re久久资源最新地址| 日韩精品毛片无码一区到三区| 中文字幕一精品亚洲无线一区| 韩国午夜福利片在线| 国内精品久久久久影院薰衣草| 污污污污污污www网站免费| 丰满少妇在线观看网站| 国产成+人+综合+亚洲 欧美| 日韩av无码成人无码免费| 国产乱人伦精品一区二区| 国产真实野战在线视频| 亚洲精品无码不卡在线播放| 亚洲人成77777在线播放网站| 久久99亚洲网美利坚合众国| 亚洲 欧美日韩 综合 国产| 久久久久99精品成人片试看| 亚洲日韩精品国产一区二区三区| 日本亚洲欧美高清专区vr专区| 无码人妻丰满熟妇区免费| 推油少妇久久99久久99久久|