在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SNAP29 Antibody

  • 中文名稱:
    SNAP29兔多克隆抗體
  • 貨號:
    CSB-PA021874ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: SNAP29 antibody at 1.79µg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: Jurkat whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 29 kDa
      Observed band size: 29 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA021874ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA021874ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SNAP29 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CEDNIK antibody; FLJ21051 antibody; SNAP 29 antibody; SNAP-29 antibody; SNAP29 antibody; SNP29_HUMAN antibody; Soluble 29 kDa NSF attachment protein antibody; Synaptosomal associated protein 29 antibody; Synaptosomal associated protein 29kDa antibody; Synaptosomal-associated protein 29 antibody; Vesicle membrane fusion protein SNAP 29 antibody; Vesicle membrane fusion protein SNAP29 antibody; Vesicle-membrane fusion protein SNAP-29 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Synaptosomal-associated protein 29 protein (1-258AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. SNAP29 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane. Plays also a role in ciliogenesis by regulating membrane fusions.
  • 基因功能參考文獻:
    1. NEK3 kinase phosphorylates SNAP29 on its serine 105. NEK3-mediated phosphorylation determines membrane localization of SNAP29. Membrane-associated SNAP29 regulates Golgi and focal adhesion structures. PMID: 29454964
    2. Here, we identify a novel role for Snap29, an unconventional SNARE, in promoting kinetochore assembly during mitosis in Drosophila and human cells. Snap29 localizes to the outer kinetochore and prevents chromosome mis-segregation and the formation of cells with fragmented nuclei. PMID: 27647876
    3. phenotypic variability in Arab families with c.223delG mutation affected by cerebral dysgenesis, neuropathy, ichthyosis and keratoderma syndrome PMID: 25958742
    4. support a role of Snap29 at key steps of membrane trafficking, and predict that signaling defects may contribute to the pathogenesis of cerebral dysgenesis PMID: 25551675
    5. In mammalian cells, mutating the O-GlcNAc sites in SNAP-29, promotes the formation of a SNAP-29-containing SNARE complex, increases fusion between autophagosomes and endosomes/lysosomes, and promotes autophagic flux. PMID: 25419848
    6. This work implicates SNAP29 as a major modifier of variable expressivity in 22q11.2 DS patients. PMID: 23231787
    7. a causal relationship between defective function of SNAP29 and the pleiotropic manifestations of CEDNIK syndrome PMID: 21073448
    8. SNAP29 mediated membrane fusion has an important role in endocytic recycling and consequently, in cell motility PMID: 20305790
    9. SNAP-29 acts as a negative modulator for neurotransmitter release, probably by slowing recycling of the SNARE-based fusion machinery and synaptic vesicle turnover PMID: 15890653
    10. a SNAP29 mutation codes for a SNARE protein involved in intracellular trafficking and causes a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma PMID: 15968592

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome (CEDNIK)
  • 亞細胞定位:
    Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein. Cell projection, cilium membrane; Peripheral membrane protein.
  • 蛋白家族:
    SNAP-25 family
  • 組織特異性:
    Found in brain, heart, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.
  • 數據庫鏈接:

    HGNC: 11133

    OMIM: 604202

    KEGG: hsa:9342

    STRING: 9606.ENSP00000215730

    UniGene: Hs.108002



主站蜘蛛池模板: 国产伦精品一区二区三区妓女| 丰满无码人妻熟妇无码区| 久久精品中文字幕有码| 中文字幕 人妻熟女| 黑人大荫蒂高潮视频| 国产九九99久久99大香伊| 美女黄网站18禁免费看| 人妻 校园 激情 另类| 国产97在线 | 免费| 综合在线视频精品专区| 国产拍揄自揄免费观看| 国产毛片久久久久久国产毛片| 亚洲午夜无码久久久久| 国产无遮挡又黄又爽在线视频| av第一福利网站| 毛片免费视频观看| 一本一道色欲综合网中文字幕| 国产午夜精华无码网站| 久久精品娱乐亚洲领先| 麻花传媒在线mv免费观看视频| 国产人妻黑人一区二区三区| 七妺福利精品导航大全| 成 人 网 站 免费观看| 午夜天堂精品久久久久| 国产精品老汉av| 亚洲中文综合网五月俺也去| 国产午夜亚洲精品国产成人小说| 亚洲国产精品久久亚洲精品| 寂寞人妻瑜伽被教练日| 日韩av片无码一区二区不卡电影 | 七七久久成人影院网站| 久久成人伊人欧洲精品| 狠狠躁天天躁中文字幕| 欧美大黑帍在线播放| 成人女人黄网站免费视频| 色妺妺视频网| 少妇精品无码一区二区三区| 人人人插人人费| 中字幕一区二区三区乱码| 少妇邻居内射在线| 国产精品久久久久久爽爽爽床戏|