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SMYD1 Antibody

  • 中文名稱:
    SMYD1兔多克隆抗體
  • 貨號:
    CSB-PA847673ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: Histone-lysine N-methyltransferase SMYD1 antibody at 2μg/ml
      Lane 1: Mouse heart tissue
      Lane 2: 293T whole cell lysate
      Lane 3: Mouse skeletal muscle tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 57 kDa
      Observed band size: 57 kDa
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA847673ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA847673ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SMYD1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SMYD1
  • 別名:
    BOP antibody; CD8 beta opposite antibody; CD8b opposite antibody; Histone lysine N methyltransferase SMYD1 antibody; KMT3D antibody; SET and MYND domain containing 1 antibody; SET and MYND domain-containing protein 1 antibody; SMYD1 antibody; SMYD1_HUMAN antibody; Zinc finger MYND domain containing 18 antibody; ZMYND18 antibody; ZMYND22 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Histone-lysine N-methyltransferase SMYD1 protein (1-350AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.
  • 基因功能參考文獻:
    1. We present genetic and statistical evidence that the R320Q substitution in SMYD1 underlies an inherited form of the AnWj-negative blood group phenotype. The mechanism by which the mutation leads to this phenotype remains to be determined. PMID: 29956848
    2. SMYD1 serves as an Serum Response Factor-interacting protein, enhances Serum Response Factor DNA binding activity, and is required for endothelial cell migration and tube formation to regulate angiogenesis. PMID: 26799706
    3. SMYD1 and G6PD modulation are critical events for miR-206-mediated differentiation of rhabdomyosarcoma. PMID: 25644430
    4. effects of gene mutations on ventricular development PMID: 12858532
    5. HDGF functions as a transcriptional repressor of the SMYD1 gene through interaction with the transcriptional corepressor CtBP. PMID: 19162039

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  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Class V-like SAM-binding methyltransferase superfamily
  • 組織特異性:
    Expression seems mostly restricted to heart and skeletal muscle.
  • 數據庫鏈接:

    HGNC: 20986

    OMIM: 606846

    KEGG: hsa:150572

    STRING: 9606.ENSP00000393453

    UniGene: Hs.516176



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