在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SMG7 Antibody

SMG7 Antibody

  • 中文名稱：
    SMG7兔多克隆抗體
  • 貨號(hào)：
    CSB-PA226815
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from HeLa cells, Jurkat cells, 293 cells and HUVEC cells, using SMG7 antibody.
    • Immunofluorescence analysis of HepG2 cells, using SMG7 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SMG7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SMG7
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human SMG7.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.
  • 基因功能參考文獻(xiàn)：
    1. Nonsense-mediated mRNA decay (NMD) substrates with PTCs undergo constitutive SMG6-dependent endocleavage, rather than SMG7-dependent exonucleolytic decay. In contrast, the turnover of NMD substrates containing upstream ORFs and long 3' UTRs involves both SMG6- and SMG7-dependent endo- and exonucleolytic decay, respectively; extent to which SMG6 and SMG7 degrade NMD substrates is determined by the mRNA architecture. PMID: 28461625
    2. Transcriptome-wide identification of nonsense-mediated mRNA decay-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways. PMID: 27864472
    3. We showed SMG7 mRNA levels in peripheral blood mononuclear cells correlated inversely with antinuclear antibody titres of patients with systemic lupus erythematosus. The inverse relationship between levels of the risk allele-associated SMG7 mRNAs and antinuclear antibody suggested the novel contribution of mRNA surveillance pathway to systemic lupus erythematosus pathogenesis. PMID: 26783109
    4. Depletion of nonsense-mediated mRNA decay pathway components Upf1, Smg5, and Smg7 led to increased levels of viral proteins and and virus release. PMID: 25211080
    5. The study demonstrates that SMG5-SMG7 and SMG6 exhibit different and non-overlapping modes of UPF1 recognition, thus pointing at distinguished roles in integrating the complex nonsense-mediated mRNA decay interaction network. PMID: 25013172
    6. Data show that phosphorylated hUPF1, the human ortholog of UPF1/SMG-2, forms a complex with human orthologs of the Caenorhabditis elegans proteins SMG-5 and SMG-7. PMID: 14636577

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16792

    OMIM: 610964

    KEGG: hsa:9887

    UniGene: Hs.591463



主站蜘蛛池模板： 久久五月精品中文字幕| 亚洲色www成人永久网址| www夜插内射视频网站| 特黄特色的大片观看免费视频| 四虎永久免费地址入口| 又黄又湿啪啪响18禁| 好男人社区www在线观看| 非洲人与性动交ccoo| 免费人成网站在线观看不卡| 国产亚洲日韩妖曝欧美| 草的我好爽视频| 青草青草久热精品视频在线观看| 人妻少妇精品专区性色av| 亚洲精品精华液一区二区| 极品少妇被猛得白浆直流草莓视频| 97人妻人人做人碰人人爽| 国产成人av激情在线播放| 国产剧情无码播放在线看| 久久超乳爆乳中文字幕| 一本大道久久东京热无码av| 97无码精品综合| 国产v在线在线观看视频免费| 老太婆性杂交欧美肥老太| 久久tv中文字幕首页| 天堂√在线中文最新版| 亚洲色大成网站www久久九| 在线观看国产精品电影| 日日摸天天摸人人看| 免免费国产aaaaa片| 亚洲国产精品无码一线岛国| 欧美成人精精品一区二区| 久久人人97超碰caoporen| 女人高潮内射99精品| 久久亚洲精品无码播放| 色综合a怡红院怡红院| 国产成人亚洲综合| 国产剧情麻豆女教师在线观看| 无码熟妇人妻av在线影片免费| 国产精品成人一区二区三区 | 成人网站免费观看| 亚洲爆乳成av人在线蜜芽|