在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SMG6 Antibody, HRP conjugated

SMG6 Antibody, HRP conjugated

  • 中文名稱(chēng)：
    SMG6兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA773032LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) SMG6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SMG6
  • 別名：
    SMG6 antibody; C17orf31 antibody; EST1A antibody; KIAA0732Telomerase-binding protein EST1A antibody; EC 3.1.-.- antibody; EST1-like protein A antibody; Ever shorter telomeres 1A antibody; Smg-6 homolog antibody; Telomerase subunit EST1A antibody; hSmg5/7a antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Telomerase-binding protein EST1A protein (251-511AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類(lèi)型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER).; Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA.
  • 基因功能參考文獻(xiàn)：
    1. Nonsense-mediated mRNA decay (NMD) substrates with PTCs undergo constitutive SMG6-dependent endocleavage, rather than SMG7-dependent exonucleolytic decay. In contrast, the turnover of NMD substrates containing upstream ORFs and long 3' UTRs involves both SMG6- and SMG7-dependent endo- and exonucleolytic decay, respectively; extent to which SMG6 and SMG7 degrade NMD substrates is determined by the mRNA architecture. PMID: 28461625
    2. Transcriptome-wide identification of nonsense-mediated mRNA decay-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways. PMID: 27864472
    3. A preferred sequence motif spanning most SMG6 cleavage sites has been discovered by analysis of endogenous non-sense-mediated mRNA decay targets. PMID: 25429978
    4. SMG6 requires UPF1 and SMG1 for nonsense-mediated mRNA decay. PMID: 25053839
    5. The study demonstrates that SMG5-SMG7 and SMG6 exhibit different and non-overlapping modes of UPF1 recognition, thus pointing at distinguished roles in integrating the complex nonsense-mediated mRNA decay interaction network. PMID: 25013172
    6. Consistent with involvement of SMG6 in the decay process full-length nonsense-containing beta-globin mRNA was increased and the Delta169 decay intermediate was decreased in cells knocked down for SMG6. PMID: 24086375
    7. The tricotetrapeptide repeat-containing domain within Est1A was sufficient for interaction with hTERT. PMID: 22011238
    8. Data show that SMG6 interacts directly with the EJC via two conserved EJC-binding motifs (EBMs). PMID: 20930030
    9. associated with most or all active telomerase in HeLa cell extracts; overexpression of hEST1A induces anaphase bridges due to chromosome-end fusions, and telomeric DNA persists at the fusion points PMID: 12676087
    10. Human EST1A is associated with most or all active telomerase and is involved either directly or indirectly in telomere elongation and telomere capping. PMID: 16820686
    11. Structural properties of the PIN domain indicate its putative active center consisting of invariant acidic amino acid residues, which is similar to the active center of 5' nucleases. PMID: 17557331
    12. Report shows that hEST1A assembles specifically with telomerase in the context of the telomerase RNA (hTR)-hTERT ribonucleoprotein, through the high affinity of hEST1A for hTR and specific protein-protein contacts with hTERT. PMID: 17940095

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus, nucleolus. Chromosome, telomere. Cytoplasm, cytosol. Note=Particularly enriched in the nucleolus.
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 17809

    OMIM: 610963

    KEGG: hsa:23293

    STRING: 9606.ENSP00000263073

    UniGene: Hs.448342



主站蜘蛛池模板： 成人无码视频97免费| 亚洲精品国产熟女久久久| 色伊人亚洲综合网站| 日韩av无码中文无码电影| av人摸人人人澡人人超碰下载| 久久亚洲精精品中文字幕| 香蕉免费一区二区三区| 日韩卡二卡三卡四卡永久入口| 久久国产福利国产秒拍飘飘网| 精品国产av 无码一区二区三区 | 久久99精品久久久久婷婷| 秋霞午夜久久午夜精品| 4hu四虎永久在线影院| 人妻丰满熟妇av无码区app| 免费中文字幕日韩欧美| 亚洲偷自拍国综合色帝国| 国产在线精品欧美日韩电影| 久久久亚洲精品一区二区三区浴池 | 久久www成人影院| 国产玉足榨精视频在线观看| 人人妻人人澡人人爽人人精品浪潮| 久久香综合精品久久伊人| 天下第一社区视频www日本| 国产欧美精品一区二区三区 | 一本久久综合亚洲鲁鲁五月天| 欧美人与动牲交app视频| 欧美日韩精品一区二区在线观看| 久久久久久免费毛片精品| 国内精品美女视频免费直播| 精品伊人久久久大香线蕉下载| 欧美人妻精品一区二区三区| 丰满少妇人妻久久久久久| 亚洲国产成人精品无码一区二区| 国精产品一区一区三区有限公司| 久久亚洲春色中文字幕久久久| 亚洲国产欧美在线人成大黄瓜| 亚洲国产美女久久久久| 亚洲第一无码精品立川理惠| 国产成人精品.视频| 久久国产乱子精品免费女| www夜插内射视频网站|