在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SMARCE1 Antibody

  • 中文名稱:
    SMARCE1兔多克隆抗體
  • 貨號:
    CSB-PA021811GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SMARCE1
  • 別名:
    BAF57 antibody; BRG1 associated factor 57 antibody; BRG1-associated factor 57 antibody; Chromatin remodeling complex BRG1 associated factor 57 antibody; FLJ35648 antibody; SMARCE 1 antibody; SMARCE1 antibody; SMCE1_HUMAN antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin e1 antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily e member 1 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human SMARCE1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.
  • 基因功能參考文獻:
    1. High SMARCE1 expression is associated with eventual relapse and metastasis in breast cancer. PMID: 28377514
    2. miR-29a promotes hepatitis B virus (HBV) replication and expression through regulating SMARCE1 in HBV-infected HepG2.2.15 cells. PMID: 28740345
    3. We report here three additional individuals with clinical features consistent with CSS and alterations in SMARCE1, one of which is novel. The probands all exhibited dysmorphic facial features, moderate developmental and cognitive delay, poor growth, and hypoplastic digital nails/phalanges, including digits not typically affected in the other genes associated with CSS. PMID: 27264197
    4. SMARCE1 mutational hits, including novel SMARCE1 mutations, were found in six of eight tested patients with clear cell meningioma PMID: 27891692
    5. An exhaustive analysis of the BAF57 molecular and biochemical properties, cellular functions, loss-of-function phenotypes in living organisms and pathological manifestations in cases of human mutations. [review] PMID: 27149204
    6. a family with a pediatric CCM patient and an adult CCM patient and several asymptomatic relatives carrying a germline SMARCE1 mutation. PMID: 26803492
    7. Addition of the EGFR inhibitor gefitinib restores the sensitivity of SMARCE1-knockdown cells to MET and ALK inhibitors in NSCLCs. Our findings link SMARCE1 to EGFR oncogenic signaling and suggest targeted treatment options for SMARCE1-deficient tumors. PMID: 25656847
    8. The results suggested that BAF57 is involved in ovarian cancer cell growth and sensitivity to anticancer agents, and that BAF57 may be a target for ovarian cancer therapy. PMID: 25611552
    9. BAF complex gene SMARCE1 is mutated in Coffin-Siris syndrome patients. PMID: 25081545
    10. Genotype-phenotype correlation of Coffin-Siris syndrome caused by mutations in SmarCE1 gene. PMID: 25168959
    11. Since both TTF1 and SMARCE1 are involved in chromatin remodeling, our results imply an epigenetic regulatory mechanism for T-cell recruitment that invites deciphering. PMID: 24880093
    12. these results demonstrate that loss of SMARCE1 is relevant to cranial as well as spinal meningiomas PMID: 25143307
    13. Data indicate that BAF57 deregulation predisposes to metastasis. PMID: 23493350
    14. Our findings identify multiple-spinal-meningioma disease as a new discrete entity and establish a key role for the SWI/SNF complex in the pathogenesis of both meningiomas and tumors with clear-cell histology. PMID: 23377182
    15. mutations in BAF57 could impinge on several oncogenic signaling pathways contributing to the origin and/or development of breast cancer. PMID: 21465167
    16. BAF57 expression was significantly associated with the surgical stage, grade of the tumor, myometrial invasion, lympho-vascular space invasion and lymph node metastasis in 111 endometrial carcinomas. PMID: 22419023
    17. Knockdown of BAF57 resulted in an accumulation of cells in the G(2)-M phase, inhibition of colony formation, and impaired growth in soft agar. Knockdown of BAF57 also caused transcriptional misregulation of various cell cycle-related gene. PMID: 20460533
    18. BAF57-mediated cell death is associated with up-regulation of proapoptotic genes including the tumor suppressor familial cylindromatosis (CYLD), which is found to be a direct target of BAF57. PMID: 16135788
    19. BAF57 is a critical regulator of estrogen receptor function in breast cancer cells PMID: 16769725
    20. Ability of SMARCE 1 in modulating the replication efficiency of HBV. PMID: 17669635

    顯示更多

    收起更多

  • 相關疾病:
    Meningioma (MNGMA); Coffin-Siris syndrome 5 (CSS5)
  • 亞細胞定位:
    Nucleus.
  • 數據庫鏈接:

    HGNC: 11109

    OMIM: 603111

    KEGG: hsa:6605

    STRING: 9606.ENSP00000323967

    UniGene: Hs.743978



主站蜘蛛池模板: 怀孕挺大肚子疯狂高潮av毛片| 亚洲男女羞羞无遮挡久久丫| 久久亚洲精品高潮综合色a片| 亚洲中文字幕乱码一区| 国产 | 欧洲野花视频天堂视频p| 无遮挡1000部拍拍拍免费| 久久精品中文字幕一区二区三区| 乱人伦无码中文视频在线| 精品国产肉丝袜久久| 中文字幕一精品亚洲无线一区| 精品少妇ay一区二区三区| 男女性潮高清免费网站| 亚洲中文字幕日产无码2020| 欧美肥婆姓交大片| 国产精品-区区久久久狼| 亚洲国产欧美不卡在线观看| 国产成人综合久久免费导航| 亚洲国产精品久久精品| 东京热人妻无码一区二区av | 国产亚洲婷婷香蕉久久精品 | 老司机久久99久久精品播放| 成人av片在线观看免费| 亚洲男人的天堂av手机在线观看| 色先锋av影音先锋在线| av中文无码乱人伦在线观看| 国产剧情无码播放在线观看| 无码高潮爽到爆的喷水视频| 日韩精品av一区二区三区| 在线人成免费视频69国产| 夜夜高潮天天爽欧美| 国产久热精品无码激情| 在线视频 亚太 国产 欧美 一区二区 | 国产午夜草莓视频在线观看| 日韩大片高清播放器| 亚洲爆乳无码专区www| 爆乳高潮喷水无码正在播放| 男女下面进入的视频免费午夜 | 国产成人av无码精品| 中文字幕人妻a片免费看 | 无码人妻一区二区三区在线视频| 国产人妻精品区一区二区三区 |