在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SMARCA5 Antibody

SMARCA5 Antibody

  • 中文名稱：
    SMARCA5兔多克隆抗體
  • 貨號：
    CSB-PA150330
  • 規格：
    ￥1100
  • 圖片：
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-7: Hepg2 cells, MCF7 cells, Jurkat cells, hela cells, A431 cells, K562 cells, lncap cells, Primary antibody: CSB-PA150330(SMARCA5 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    4933427E24Rik antibody; D030040M08Rik antibody; D330027N15Rik antibody; EC 3.6.1.- antibody; hISWI antibody; hSNF2H antibody; ISWI antibody; MommeD4 antibody; SMARCA5 antibody; SMCA5_HUMAN antibody; Snf2h antibody; Sucrose nonfermenting like 5 antibody; Sucrose nonfermenting protein 2 homolog antibody; Sucrose nonfermenting, yeast, homolog of antibody; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 antibody; WCRF135 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human SMARCA5
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Helicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair; this may require intact histone H4 tails. Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template. Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes. The BAZ1A/ACF1-, BAZ1B/WSTF-, BAZ2A/TIP5- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner. The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template. Binds to core histones together with RSF1, and is required for the assembly of regular nucleosome arrays by the RSF-5 ISWI chromatin-remodeling complex. Involved in DNA replication and together with BAZ1A/ACF1 is required for replication of pericentric heterochromatin in S-phase. Probably plays a role in repression of RNA polymerase I dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH-5 ISWI chromatin-remodeling complex (also called the WICH complex), a chromatin-remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH-5 ISWI chromatin-remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription. Within the B-WICH complex has a role in RNA polymerase III transcription. Mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of NoRC-5 ISWI chromatin-remodeling complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.
  • 基因功能參考文獻：
    1. our data show circSMARCA5 as a promising druggable tumor suppressor in GBM and suggest that it may exert its function by tethering the RBP SRSF1. PMID: 29415469
    2. miR-151-5p, targeting chromatin remodeler SMARCA5, may act as a useful biomarker for BRCA-related and sporadic breast cancers. PMID: 27385001
    3. BAZ1A and BAZ1B promote recovery after DNA damage in part by recruiting SMARCA5 to damaged chromatin. PMID: 29021563
    4. Overexpression of hSNF2H is associated with glioma. PMID: 26666816
    5. The action of SNF2H at CTCF sites is functionally important as depletion of CTCF or SNF2H affects transcription of a common group of genes. PMID: 27019336
    6. Knockdown of SMARCA5 expression in MDA-MB-231 and MDA-MB-435s cell lines. PMID: 25377162
    7. Data show the mechanism of nucleosome sliding by the chromatin remodeling motor SNF2h protein. PMID: 25684208
    8. CHD3.1 and ACF1-SNF2H display counteractive activities but similar histone affinities. PMID: 25533843
    9. Data show that CCCTC-binding factor (CTCF) together with ISWI ATPase SMARCA5 and members of the Cohesin complex associate with the SPI1 protein is disrupted in acute myeloid leukemia (AML) blasts. PMID: 24498324
    10. SMARCA5 targeting to UV-C damage depends on transcription and histone modifications and requires functional SWI2/SNF2-ATPase and SLIDE domains. PMID: 24990377
    11. this study finds that the H4 tail promotes ATP-binding pocket closure in SNF2h. PMID: 24607692
    12. study unveils a functional link between DNA damage-induced poly(ADP-ribosyl)ation, SMARCA5-mediated chromatin remodeling and RNF168-dependent signaling and repair of DSBs. PMID: 23264744
    13. Data indicate that the heterochromatic H2A.X is preferentially phosphorylated presumably by the accumulating WSTF-ISWI chromatin remodeling (WICH) complex, and suggests that Tyr142p might have a specific role in heterochromatin. PMID: 23319141
    14. Introduction of the miR-99 family of miRNAs into cells reduced the rate and overall efficiency of repair by both homologous recombination and non-homologous end joining. PMID: 22525276
    15. Functional interaction is characterized between C/EBPbeta and SNF2H/ACF1, involving mainly suppression of C/EBPbeta transactivation activity in the presence of SNF2H and ACF1. PMID: 22242598
    16. [review] Biochemical analysis using a mutant Vpr HIV-1 gene suggests that Vpr binds chromatin-remodeling factor SNF2h via HFRIG (i.e., amino acids 71-75). PMID: 21519849
    17. These results demonstrate a novel role for ISWI (SNF2h) as a survival factor during the cellular response to hypoxia PMID: 21900490
    18. ISWI proteins Snf2H, Snf2L as well as Acf1 accumulate at UV-induced DNA damage sites within tens of seconds and reach a plateau after a few minutes. PMID: 21738833
    19. Cdt1- and SNF2H-mediated promotion of MCM loading may be biologically relevant for the regulation of DNA replication. PMID: 21937426
    20. SNF2H is required for efficient HSV-1 replication and promotes virus immediate-early gene expression. PMID: 21249171
    21. This is the first description of a fusion between EWSR1 and a chromatin-reorganizing gene(SMARCA5) in Ewing sarcoma/PNET. PMID: 21113140
    22. SMARCA5 has a potential role in proliferation and malignancy in gastric carcinogenesis. PMID: 21261476
    23. The ATP-dependent chromatin-remodeling factor, SNF2H, accumulate rapidly at DSBs and is required for DSB repair in human cells. PMID: 21172662
    24. ISWI remodelers operate via a "continuous sampling" mechanism. PMID: 20974961
    25. Data conclude that H2A.Z incorporation increases nucleosome remodeling activity of the largest class of mammalian remodelers (ISWI) and that it correlates with increased association of other remodelers to chromatin. PMID: 19940112
    26. Human RSF is composed of two subunits: ATPase hSNF2H and p325 (Rsf-1). PMID: 12972596
    27. WSTF-ISWI complex has a role in the maintenance of chromatin structures during DNA replication. PMID: 15543136
    28. Nuclear myosin 1 (NM1)-Williams syndrome transcription factor (WSTF)-SMARCA5/SNF2h complex binds RNA polymerase I and ribosomal DNA rDNA). PMID: 16514417
    29. WSTF-SNF2h-NM1 forms a platform in transcription while providing chromatin remodeling PMID: 16603771
    30. ACF1 alters the remodeling strategy of SNF2h PMID: 16877760
    31. findings suggest that interaction between Rsf-1 and hSNF2H may define a survival signal in those tumors overexpressing Rsf-1 PMID: 18519663
    32. The ability to sense adjacent DNA is a general property of the binding partners of SNF2h and that each partner provides distinct regulation that contributes to distinct cellular function. PMID: 18553938

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    SNF2/RAD54 helicase family, ISWI subfamily
  • 組織特異性：
    Ubiquitously expressed.
  • 數據庫鏈接：

    HGNC: 11101

    OMIM: 603375

    KEGG: hsa:8467

    STRING: 9606.ENSP00000283131

    UniGene: Hs.558422



主站蜘蛛池模板： 亚洲成av人片在线观l看福利1| 99精品国产在热久久无码| 亚洲视频日本有码中文| 精品偷拍被偷拍在线观看| 国产欧美日韩视频一区二区三区 | 无遮挡aaaaa大片免费看| 精品国产一区二区三区四区精华液| 亚洲中文有码字幕日本第一页| 国产成人av在线影院无毒| 色综合久久久无码网中文| 狠狠97人人婷婷五月| 中文综合在线观| 精品国产三级a在线观看| 日本午夜免a费看大片中文4| 亚洲熟女av乱码在线观看漫画| 把女邻居弄到潮喷的性经历| 久久婷婷五月综合色中文字幕| 中文字幕精品久久久乱码乱码| 国产在线视频天天综合网| 亚洲无线码中文字幕在线| 国产精品视频一区二区噜噜| 男人和女人高潮免费网站| 国产成av人片在线观看天堂无码| 丰满人妻被黑人中出849| 男人狂躁进女人下面免费视频| 无码人妻丰满熟妇啪啪欧美| 秋霞国产午夜伦午夜福利片| 伊人久久久av老熟妇色| 国产精品日本亚洲欧美| 国产精品亚韩精品无码a在线 | 四虎国产精品永久在线| 免费无码一区二区三区蜜桃大| 成人亚洲欧美日韩在线观看| 亚洲熟妇丰满xxxxx| 久久人人爽人人人人片| 狠狠色婷婷久久综合频道日韩 | 国产午夜亚洲精品理论片不卡| 欧美三级午夜理伦三级| 国产精品久久无码一区二区三区网| 播五月开心婷婷欧美综合| 日本无卡码高清免费v|