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  4. SMARCA1 Antibody, HRP conjugated

SMARCA1 Antibody, HRP conjugated

  • 中文名稱：
    SMARCA1兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA021798LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SMARCA1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SMARCA1
  • 別名：
    SMARCA1 antibody; SNF2L antibody; SNF2L1 antibody; Probable global transcription activator SNF2L1 antibody; EC 3.6.4.- antibody; ATP-dependent helicase SMARCA1 antibody; Nucleosome-remodeling factor subunit SNF2L antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Probable global transcription activator SNF2L1 protein (500-601AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalytically inactive when either DNA or nucleosomes are the substrate and does not possess chromatin-remodeling activity. Acts as a negative regulator of chromatin remodelers by generating inactive complexes.; Helicase that possesses intrinsic ATP-dependent chromatin-remodeling activity. ATPase activity is substrate-dependent, and is increased when nucleosomes are the substrate, but is also catalytically active when DNA alone is the substrate. Catalytic subunit of ISWI chromatin-remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. Within the ISWI chromatin-remodeling complexes, slides edge- and center-positioned histone octamers away from their original location on the DNA template. Catalytic activity and histone octamer sliding propensity is regulated and determined by components of the ISWI chromatin-remodeling complexes. The BAZ1A-, BAZ1B-, BAZ2A- and BAZ2B-containing ISWI chromatin-remodeling complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template. The CECR2- and RSF1-containing ISWI chromatin-remodeling complexes do not have the ability to slide mononucleosomes to the center of a DNA template. Within the NURF-1 and CERF-1 ISWI chromatin remodeling complexes, nucleosomes are the preferred substrate for its ATPase activity. Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development. May promote neurite outgrowth. May be involved in the development of luteal cells.
  • 基因功能參考文獻：
    1. In one family, four siblings with a psychotic illness and their unaffected mother each carry a novel private missense variant in the SMARCA1 gene on the X chromosome. PMID: 27001614
    2. Depletion of a chromatin remodeler, SMARCA1, in cancer cell lines promoted their growth. PMID: 25462860
    3. The results suggest that the cAMP-response element consensus sequence in the SNF2L proximal promoter most likely confers constitutive activation and regulation by cAMP in neural cells. PMID: 23549828
    4. The effect of SNF2L depletion on gene expression portray the cell in a state of activated Wnt signaling with increased proliferation and locomotion. High levels of SNF2L expression in normal melanocytes contrast with undetectable expression in melanoma. PMID: 22508985
    5. expression profiling analyses revealed that SWI/SNF likely antagonizes Polycomb repressive complex 2, implicating this as one possible mechanism of tumor suppression PMID: 22233809
    6. ISWI proteins Snf2H, Snf2L as well as Acf1 accumulate at UV-induced DNA damage sites within tens of seconds and reach a plateau after a few minutes. PMID: 21738833
    7. Cancers are sensitive to SNF2L knockdown because, unlike their normal counterparts, they lack sufficient compensation from other family members. PMID: 19996304
    8. a neuronal SNF2L variant inactivates chromatin remodeling PMID: 15310751
    9. Brahma and Brahma/SWI2-related gene 1 have roles in hypoxic induction of the erythropoietin gene PMID: 15347669
    10. This study provides the first insight into the mechanisms that control basal expression of human SNF2L gene. PMID: 18243132
    11. SNF2L mutations are not a cause of X-linked mental retardation in our cohort of patients, although we cannot exclude the possibility that regulatory mutations might exist PMID: 18302774

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    SNF2/RAD54 helicase family, ISWI subfamily
  • 組織特異性：
    [Isoform 1]: Mainly expressed in non-neuronal tissues such as lung, breast, kidney, and ovary.; [Isoform 2]: Expressed in lung, breast, kidney, ovary, skeletal muscle and brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11097

    OMIM: 300012

    KEGG: hsa:6594

    STRING: 9606.ENSP00000360163

    UniGene: Hs.152292



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