在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SMAD5 Antibody

  • 中文名稱:
    SMAD5兔多克隆抗體
  • 貨號:
    CSB-PA859108LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human melanoma using CSB-PA859108LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA859108LA01HU at dilution of 1:100
    • Immunofluorescent analysis of MCF-7 cells using CSB-PA859108LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: Mouse heart tissue, Mouse lung tissue, Mouse kidney tissue
      All lanes: SMAD5 antibody at 3μg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 53 kDa
      Observed band size: 53 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SMAD5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    DKFZp781C1895 antibody; DKFZp781O1323 antibody; Dwfc antibody; hSmad5 antibody; JV5 1 antibody; JV5-1 antibody; MAD homolog 5 antibody; MAD, mothers against decapentaplegic homolog 5 antibody; MADH 5 antibody; MADH5 antibody; Mothers against decapentaplegic homolog 5 antibody; mothers against decapentaplegic, drosophila, homolog of, 5 antibody; Mothers against DPP homolog 5 antibody; MusMLP antibody; SMA and MAD related protein 5 antibody; SMAD 5 antibody; SMAD family member 5 antibody; SMAD, mothers against DPP homolog 5 antibody; Smad5 antibody; SMAD5_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Mothers against decapentaplegic homolog 5 protein (1-209AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,SMAD5 Antibody (CSB-PA859108LA01HU),的標記方式是Non-conjugated。對于SMAD5 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA859108LB01HU SMAD5 Antibody, HRP conjugated ELISA
    FITC CSB-PA859108LC01HU SMAD5 Antibody, FITC conjugated
    Biotin CSB-PA859108LD01HU SMAD5 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).
  • 基因功能參考文獻:
    1. We demonstrated high expression of miR-145 associated with late stage and unfavorable prognosis of esophageal cancer. We identified SMAD5 as direct target of miR-145, the suppressed expression of which consequently led to increased cell proliferation and migration/invasion. PMID: 29852786
    2. Smad5 acts as a intracellular pH messenger and maintains the bioenergetic homeostasis of cells by regulating cytoplasmic metabolic machinery. PMID: 28675158
    3. Data suggest that differences in expression levels in granulosa-like tumor cells and granulosa cells (GCs) from patients with polycystic ovary syndrome (PCOS) are due to increased expression of microRNA-27a-3p in GCs caused by insulin resistance in PCOS; microRNA-27a-3 expression is up-regulated in GCs in PCOS; overexpression of miR-27a-3p inhibits SMAD5 expression and promotes apoptosis. (SMAD5 = SMAD family member 5) PMID: 29029022
    4. Here the involvement of the pathway in adult brain function is suggested. This exploratory study establishes a strategy to better identify neuronal molecular signatures that are potentially associated with mental illness and cognitive deficits. We propose that the SMAD pathway may be a novel target in addressing cognitive deficit of SZ in future studies. PMID: 27727244
    5. miR-23a and miR-27a target SMAD5 and regulate apoptosis in human granulosa cells via the FasL-Fas pathway PMID: 26400397
    6. Our findings suggest that suppression of miR-222-3p activity promoted osteogenic differentiation hBMSCs through regulating Smad5-RUNX2 signaling axis. PMID: 26809090
    7. The polycomb group protein L3MBTL1 represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells. PMID: 25754204
    8. among the 15 SNPs, rs3206634 was significantly associated with KD in a recessive model (odds ratio = 2.31, p = 0.019), whereas there was no association between any of the 15 SNPs and CALs. PMID: 24163009
    9. Specific gene siRNAs knock-down further confirmed the osteogenic effects of Genistein on BMP2, SMAD5 and RUNX2 protein expression PMID: 24339730
    10. ATP production by NaF promotes hypertrophy-like changes via activation of phospho-Smad5 PMID: 23384547
    11. found that restoration of SMAD5, in addition to the TGF-beta type II receptor, which was epigenetically silenced by the latent viral protein latency-associated nuclear antigen, sensitized BC3 cells to the cytostatic effect of TGF-beta signaling PMID: 22013049
    12. Studies indicate SMAD5beta isoform plays role in hematopoietic stem cell homeostasis. PMID: 20148926
    13. regulatory signals are active at transcriptionally subnuclear sites PMID: 12060751
    14. Smad5 activation by BMP4 in human hematopoietic cells results in significantly increased proliferation of erythroid progenitors and formation of glycophorin-A+ cells. PMID: 12064918
    15. up-regulated Smad5 mediates apoptosis of gastric epithelial cells induced by Helicobacter pylori infection PMID: 12473652
    16. Results demonstrate a mitochondrial distribution of Smad5 in non-stimulated chondroprogenitor cells. PMID: 12849988
    17. SMAD5 undergoes copy number gain and increased expression, rather than loss of expression, and therefore does not act as a tumor-suppressor gene in hepatocellular carcinoma PMID: 14670176
    18. In mature human B cells, BMP-6 inhibited cell growth, and rapidly induced phosphorylation of Smad5. PMID: 15877825
    19. We used homology-modeling techniques to generate a reliable molecular model of the Smad5 MH1 domain based on the crystal structure of Smad3 MH1 domain PMID: 16243555
    20. SMAD5 gene was found to be associated with schizophrenia. PMID: 18298822

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.
  • 蛋白家族:
    Dwarfin/SMAD family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 6771

    OMIM: 603110

    KEGG: hsa:4090

    STRING: 9606.ENSP00000441954

    UniGene: Hs.167700



主站蜘蛛池模板: 日韩经典午夜福利发布| 日本乱妇乱子视频| 在教室伦流澡到高潮hgl视频| 韩国精品一区二区无码视频| 国产好爽…又高潮了毛片| 国产做a爱免费视频在线观看| 欧美丰满老熟妇乱叫| 巨人精品福利官方导航| 国产人澡人澡澡澡人碰视频| 夜夜躁狠狠躁日日躁202| 欧美高清大屁股xxxxx| 搡女人真爽免费视频大全| 伊人蕉久中文字幕无码专区| 97精品国自产在线偷拍| 欧美亚洲日韩不卡在线在线观看| 中文字幕高清免费日韩视频在线 | 99在线 | 亚洲| 国产av一区二区精品久久| 久久中文字幕人妻熟av女蜜柚m| 国产拍拍拍无码视频免费| 国偷自产一区二区三区在线视频| 色五月丁香六月欧美综合| 亚洲乱亚洲乱少妇无码99p| 四虎影视88aa久久人妻| 国语少妇高潮对白在线| 国产真实夫妇视频| 国产精品成人a区在线观看| 亚洲精品国产一区二区精华| 亚洲欧美日韩一区二区| 天堂√在线中文官网在线| 久久综合97丁香色香蕉| 日韩精品无码不卡无码| 中文国产成人精品久久不卡| 国产国语毛片在线看国产| 夜夜欢性恔真人免费视频| 成在线人av免费无码高潮喷水 | 欧美网站免费观看在线| 激烈的性高湖波多野结衣| 色窝窝无码一区二区三区色欲| 男人添女人下部高潮视频| 天天躁夜夜躁天干天干2020|