在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLN Antibody

  • 中文名稱:
    SLN兔多克隆抗體
  • 貨號:
    CSB-PA021780GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SLN
  • 別名:
    SLN antibody; Sarcolipin antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human SLN
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Reversibly inhibits the activity of ATP2A1 and ATP2A2 in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in muscle. Required for muscle-based, non-shivering thermogenesis.
  • 基因功能參考文獻:
    1. Structure-Function Relationship of the SERCA Pump and Its Regulation by Phospholamban and Sarcolipin. PMID: 29594859
    2. Self-assembling study of sarcolipin and its mutants in multiple molecular dynamic simulations has been reported. PMID: 28241400
    3. These results suggest that sAnk1 interacts with SLN both directly and in complex with SERCA1 and reduces SLN's inhibitory effect on SERCA1 activity. PMID: 28487373
    4. analysis of transmembrane dynamics of the Thr-5 phosphorylated sarcolipin pentameric channel PMID: 27378083
    5. Phospholamban and sarcolipin are membrane proteins that differentially regulate SERCA function. (Review) PMID: 26743715
    6. Molecular dynamics simulations help to clarify and to understand better the SLN pentamer channel that had a hydrophobic gate and could switch Na(+) and Cl(-) ion permeability by hydrated and vacuum states. PMID: 26522287
    7. Although SLN and PLB binding to SERCA have different functional outcomes on the coupling efficiency of SERCA, both proteins decrease the apparent Ca(2+) affinity of the pump, suggesting that SLN and PLB inhibit SERCA by using a similar mechanism. PMID: 25983321
    8. SLN and PLN are co-expressed in most fibers, which suggests that super-inhibition of SERCAs may be physiologically important in the regulation of intracellular Ca2+ in human skeletal muscle. PMID: 24358354
    9. The C-terminal tail of SLN is a distinct, essential domain in the regulation of SERCA. PMID: 23362265
    10. The selective downregulation of SLN and enhanced sarcoplasmic reticulum Ca(2+) uptake in human AF suggest that SLN downregulation could play an important role in abnormal intracellular Ca(2+) cycling in atrial pathology. PMID: 21640081
    11. sarcolipin binds to phospholamban and inhibits polymerization PMID: 12032137
    12. sarcolipin is likely to be an atrial chamber-specific regulator of Ca2+ cycling in heart PMID: 12645548
    13. role in regulating sarco(endo)plasmic reticulum Ca2+-ATPase by binding to transmembrane helices alone or in association with phospholamban PMID: 12692302
    14. Gene expression of SLN was studied in children with congenital heart defects. PMID: 17515962

    顯示更多

    收起更多

  • 亞細胞定位:
    Sarcoplasmic reticulum membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族:
    Sarcolipin family
  • 數據庫鏈接:

    HGNC: 11089

    OMIM: 602203

    KEGG: hsa:6588

    STRING: 9606.ENSP00000304707

    UniGene: Hs.334629



主站蜘蛛池模板: 99视频偷窥在线精品国自产拍| 国产精品日日做人人爱| 美女扒开尿口让男人桶| 妺妺跟我一起洗澡没忍住| 偷偷要色偷偷中文无码| 超级碰97直线国产免费公开| 国产精品夜夜春夜夜爽久久| 国产精品调教视频一区| 毛片免费视频在线观看| 黄a无码片内射无码视频| 日本人妻人人人澡人人爽| 久草热8精品视频在线观看| 天堂va欧美ⅴa亚洲va| 亚洲精品gv天堂无码男同| 蜜臀av无码精品人妻色欲| 人人妻人人澡人人爽人人精品av| 亚洲精品v天堂中文字幕| 国产一区二区三区在线视頻 | 国产成人午夜福利电影在线播放| 欧美疯狂xxxxbbbb喷潮 | 中文在线√天堂| 99久久无码一区人妻a片蜜| 邻居少妇张开腿让我爽了一夜 | 人妻少妇精品无码专区二区| 一本之道高清乱码久久久| 欧美成人一卡二卡三卡四卡| 无码人妻丰满熟妇a片护士| 亚洲日本va午夜中文字幕一区| 国产无套内射又大又猛又粗又爽 | 青椒国产97在线熟女| 中文字幕资源网| 国产精品一线二线三线| 中文字幕一区二区三区精华液| 亚拍精品一区二区三区探花| 中文字幕在线影视| 精品久久久无码人妻中文字幕| 亚洲国产天堂久久综合| 福利视频一二三在线观看| 人妻熟妇乱又伦精品hd| 好爽…又高潮了毛片免费看| 国产亚洲精品aaaaaaa片|