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  4. SLK Antibody

SLK Antibody

  • 中文名稱：
    SLK兔多克隆抗體
  • 貨號：
    CSB-PA004103
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of COLO205 cells using SLK Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SLK
  • 別名：
    SLK antibody; KIAA0204 antibody; STK2 antibody; STE20-like serine/threonine-protein kinase antibody; STE20-like kinase antibody; hSLK antibody; EC 2.7.11.1 antibody; CTCL tumor antigen se20-9 antibody; STE20-related serine/threonine-protein kinase antibody; STE20-related kinase antibody; Serine/threonine-protein kinase 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human SLK.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, IF, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Mediates apoptosis and actin stress fiber dissolution.
  • 基因功能參考文獻：
    1. SLK interacts with Tpr and alpha-actinin-4 in cells, and these protein-protein interactions may control the subcellular localization and the biological activity of SLK. PMID: 26094769
    2. SLK activated ERMs, together with Galphai, are critical for the correct localization of LGN-NuMA force generator complexes and hence for proper spindle orientation. PMID: 24958772
    3. The fact that SLK (LOSK) phosphorylates only a minor isoform 1A of p150(Glued) suggests that transport and microtubule-organizing functions of dynactin are distinctly divided between the two isoforms PMID: 23985322
    4. v-Src-dependent down-regulation of the Ste20-like kinase SLK through casein kinase II. PMID: 16837460
    5. we show that a novel isoform of SPS1-related proline alanine-rich kinase (SPAK/STE20) is involved in this inflammatory signaling cascade PMID: 17321610
    6. Protein kinase LOSK is required for radial microtubule organization and for the proper localization of Golgi complex in various cell types. PMID: 18287541
    7. Studies define an interaction between Neu and SLK signaling in the regulation of cancer cell motility. PMID: 19525980

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
  • 組織特異性：
    Ubiquitously expressed. Highest expression is found in heart and in skeletal muscle.
  • 數據庫鏈接：

    HGNC: 11088

    OMIM: 616563

    KEGG: hsa:9748

    STRING: 9606.ENSP00000358770

    UniGene: Hs.591922



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