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  4. SLIT3 Antibody, Biotin conjugated

SLIT3 Antibody, Biotin conjugated

  • 中文名稱：
    SLIT3兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA021769LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SLIT3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLIT3
  • 別名：
    FLJ10764 antibody; KIAA0814 antibody; MEGF 5 antibody; MEGF5 antibody; Multiple EGF-like domains protein 5 antibody; Multiple epidermal growth factor like domains 5 antibody; Multiple epidermal growth factor-like domains protein 5 antibody; SLIL 2 antibody; SLIL2 antibody; SLIT 1 antibody; Slit 2 antibody; Slit 3 antibody; Slit homolog 3 (Drosophila) antibody; Slit homolog 3 antibody; Slit homolog 3 protein antibody; Slit-3 antibody; SLIT1 antibody; Slit2 antibody; Slit3 antibody; SLIT3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Slit homolog 3 protein (1199-1494AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May act as molecular guidance cue in cellular migration, and function may be mediated by interaction with roundabout homolog receptors.
  • 基因功能參考文獻：
    1. Overexpression of Slit3 induces its tumor suppressive effects in Breast cancer. PMID: 26542734
    2. Results show that silencing of Slit3 promoted proliferation, migration and invasion of A549 cells and induced epithelial-mesenchymal transition suggesting that Slit3 functions as a tumor suppressor in lung carcinoma. PMID: 26045181
    3. Estrogen-dependent expression of SLIT3 may play a key role in regulating nerve-vessel interactions within the complex microenvironment of endometriosis lesions. PMID: 25051436
    4. SLIT3 is increased with labour, and both amnion and myometrial studies describe a pro-inflammatory effect of SLIT3 in these tissues. PMID: 24286238
    5. High SLIT3 expression is associated with high-grade gliomas. PMID: 24158112
    6. SLIT3-ROBO4 activation promotes vascular network formation in human engineered tissue and angiogenesis in vivo. PMID: 24090675
    7. results implicate the involvement of miR-218-2 and its host gene SLIT3 in thyroid cancer cell invasion, migration, and proliferation PMID: 23720784
    8. Slit3 treatment increased the in vivo homing efficiency of CD34 HSPCs to the BM in NOD/SCID mice, whereas Slit3-exposed HSPC migration in vitro was inhibited. Results support a role for Slit3 in human HSPC migration in vitro and homing in vivo. PMID: 22614124
    9. SLIT3 duplication on 5q35.1 predisposes to major depressive disorder PMID: 21152026
    10. The chemorepellent Slit3 promotes monocyte migration. PMID: 21078908
    11. Slit3 inhibits Robo3-induced invasion of synovial fibroblasts in rheumatoid arthritis. PMID: 20298552
    12. Many variants in SLIT3 tend to associate with schizophrenia susceptibility in the Chinese Han population. PMID: 15231749
    13. data suggest that Slit proteins play a key role in guiding dorsally projecting cranial motoneurons and in facilitating their neural tube exit PMID: 16162649
    14. In fetal and embryonic stem cell cultures Slit-3 inhibited neurite outgrowth. PMID: 16840550
    15. functions to promote angiogenesis in coordinating organogenesis during embryonic development PMID: 19741192

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  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    Predominantly expressed in thyroid.
  • 數據庫鏈接：

    HGNC: 11087

    OMIM: 603745

    KEGG: hsa:6586

    STRING: 9606.ENSP00000430333

    UniGene: Hs.552087



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