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  4. SLFN11 Antibody, Biotin conjugated

SLFN11 Antibody, Biotin conjugated

  • 中文名稱：
    SLFN11兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA021760LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SLFN11 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    SLFN11 antibody; Schlafen family member 11 antibody; EC 3.6.-.- antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Schlafen family member 11 protein (670-821AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Inhibitor of DNA replication that promotes cell death in response to DNA damage. Acts as a guardian of the genome by killing cells with defective replication. Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death. Acts independently of ATR. Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA.
  • 基因功能參考文獻：
    1. SLFN11 contributes to the sensitivity of Ewing sarcoma cells to inhibition of ribonucleotide reductase M2 PMID: 27557498
    2. SLFN11 is frequently methylated in human colorectal cancer, and the expression of SLFN11 is regulated by promoter region methylation. Methylation of SLFN11 reduced the sensitivity of CRC cells to cisplatin. PMID: 28403629
    3. SLFN11 is a relevant predictive biomarker of sensitivity to PARP inhibitor monotherapy in SCLC and we identify combinatorial therapy with TMZ as a particularly promising therapeutic strategy that warrants further clinical investigation PMID: 27440269
    4. DNA methylation at SLFN11 cg10911913 was positively associated with measured levels of all 3 PM2.5 species. PMID: 27982729
    5. In vivo silencing of SLFN11 was associated with marked deposition of H3K27me3, a histone modification placed by EZH2, within the gene body of SLFN11, inducing local chromatin condensation and gene silencing. PMID: 28196596
    6. the results identify SLFN11 epigenetic inactivation as a predictor of resistance to platinum drugs in human cancer. PMID: 26625211
    7. SLFN11 inhibits checkpoint maintenance and homologous recombination repair by promoting the destabilization of the RPA-ssDNA complex, thereby sensitizing cancer cell lines expressing high endogenous levels of SLFN11 to DNA-damaging agents. PMID: 26658330
    8. SLFN11 has a role as a transcriptional target of EWS-FLI1 and is a determinant of drug response in Ewing sarcoma PMID: 25779942
    9. SLFN11 expression predicts good better survival in colorectal cancer patients with KRAS exon 2 wild type who have received oxaliplatin based adjuvant chemotherapy. PMID: 26525741
    10. SLFN11 selectively inhibits viral protein synthesis in HIV-infected cells by means of codon-bias discrimination PMID: 23000900
    11. SLFN11 expression is causally associated with the activity of DNA-damaging agents in cancer cells, and has a broad expression range in colon and ovarian adenocarcinomas. PMID: 22927417

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  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Schlafen family
  • 組織特異性：
    Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 26633

    OMIM: 614953

    KEGG: hsa:91607

    STRING: 9606.ENSP00000312402

    UniGene: Hs.745059



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