在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC9A6 Antibody

  • 中文名稱:
    SLC9A6兔多克隆抗體
  • 貨號(hào):
    CSB-PA821677ESR1HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA821677ESR1HU at dilution of 1:100
    • Immunofluorescent analysis of 293 cells using CSB-PA821677ESR1HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SLC9A6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    3732426M05 antibody; 6430520C02Rik antibody; KIAA0267 antibody; mKIAA0267 antibody; MRSA antibody; Na(+)/H(+) exchanger 6 antibody; NHE-6 antibody; NHE6 antibody; OTTHUMP00000024089 antibody; OTTHUMP00000024090 antibody; RGD1563582 antibody; RP11-274K13.1 antibody; RP23-105E2.4 antibody; SL9A6_HUMAN antibody; SLC9A6 antibody; Sodium/hydrogen exchanger 6 antibody; Solute carrier family 9 (sodium/hydrogen exchanger); isoform 6 antibody; Solute carrier family 9 (sodium/hydrogen exchanger); member 6 antibody; Solute carrier family 9 member 6 antibody; solute carrier family 9; subfamily A (NHE6; cation proton antiporter 6); member 6 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Sodium/hydrogen exchanger 6 protein (510-669AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis.
  • 基因功能參考文獻(xiàn):
    1. membrane trafficking of the ES mutant in SLC9A6was impaired and elicited marked reductions in total dendritic length, area and arborization, and triggered apoptotic cell death PMID: 27590723
    2. by sequencing panels of genes in patients with no precise clinical diagnosis, NGS can broaden the clinical variability associated with a known gene. We also argue that SLC9A6 gene mutations in females could be responsible for a monogenic cause of mild learning disability/constitutive speech disorders. PMID: 27256868
    3. We describe a large extended family with three affected males, four carrier females, one presumed carrier female and one obligate carrier female with a c.190G>T, p.E64X mutation known to cause a premature stop codon in SLC9A6 PMID: 27142213
    4. Epileptic encephalopathy related to mutations in the SLC9A6 genes. PMID: 25818041
    5. Data show that co-expression with sodium-hydrogen antiporter NHE6 or treatment with the Na(+)/H(+) ionophore monensin shifted amyloid precursor protein (APP) away from the trans-Golgi network into early and recycling endosomes in HEK293 cells. PMID: 25561733
    6. This study demonistrated that Genetic and phenotypic diversity of NHE6 mutations in Christianson syndrome. PMID: 25044251
    7. find interesting gene expression changes in endosomal NHE6 and NHE9 in postmortem autism brains. PMID: 23508127
    8. Data indicate SLC9A6 mutations and the clinical uniformity of male patients with Christianson syndrome in two familieis. PMID: 22931061
    9. We report on a 22year-old male patient with Christianson syndrome carrying the novel p.Gln306X mutation in SLC9A6 PMID: 22541666
    10. The involvement of SLC9A6 mutations in 22 males initially suspected to have Angelman syndrome (AS) but found on genetic testing not to have AS (AS-like cohort), and 104 male patients with X-linked mental retardation (XMR) (XMR cohort), was investigated. PMID: 21812100
    11. These observations suggest that NHE6 regulates clathrin-dependent endocytosis of transferrin via pH regulation. PMID: 21881004
    12. In mineralizing osteoblasts, slightly basic basal intracellular pH is maintained, and external acid load is dissipated, by high-capacity Na(+) /H(+) exchange via NHE1 and NHE6. PMID: 21413028
    13. This review defines NHE6-9 as organellar NHEs that are fairly dynamic, implying that they are subjected to intracellular trafficking and thus they continuously shuttle between organelles and the plasma membrane. PMID: 21171650
    14. NHE6 in the endosomal recycling system is involved in the development of apical bile canalicular surface domains in HepG2 cells PMID: 20130086
    15. NHE6 with alanine substitutions in the membrane-proximal region exhibited no apparent change in localization. PMID: 20364249
    16. Analysis identified an in-frame 9 base pair deletion in the solute carrier family 9, isoform A6 (SLC9A6 gene), which encodes sodium/hydrogen exchanger-6 localized to endosomal vesicles. PMID: 20395263
    17. results suggest that NHE6 is an endosomal Na(+)/H(+) exchanger that may regulate intravesicular pH and volume and contribute to lysosomal biogenesis PMID: 11940519
    18. distribution of NHE6 between endosomes and plasma membrane is regulated by RACK1 PMID: 18057008
    19. Mutations in SLC9A6 cause X-linked mental retardation;males with findings suggestive of unexplained Angelman syndrome should be considered as potential candidates for SLC9A6 mutations. PMID: 18342287
    20. NHE6 participates in regulation of endosomal pH and provides a basis for understanding loss of NHE6 function leading to a phenotype resembling Angelman syndrome. PMID: 19619532

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Mental retardation, X-linked, syndromic, Christianson type (MRXSCH)
  • 亞細(xì)胞定位:
    Endosome membrane; Multi-pass membrane protein. Note=Is present in the recycling compartments including early and recycling endosomes, and only appears transiently on the plasma membrane.; [Isoform 2]: Recycling endosome membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
  • 組織特異性:
    Ubiquitous; but is most abundant in mitochondrion-rich tissues such as brain, skeletal muscle and heart.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 11079

    OMIM: 300231

    KEGG: hsa:10479

    STRING: 9606.ENSP00000359729

    UniGene: Hs.62185



主站蜘蛛池模板: 日本动漫瀑乳h动漫啪啪免费| 国产丝袜在线精品丝袜不卡| 3d成人h动漫网站入口| 久久精品人妻中文系列| 艳妇臀荡乳欲伦交换h在线观看| 国产无线乱码一区二三区| av毛片无码中文字幕不卡| 亚洲日韩色欲色欲com| 日日碰狠狠躁久久躁婷婷 | 精品一区二区三区无码免费视频 | 国产av麻豆天堂亚洲国产av刚刚碰| 激情综合丁香五月| 强睡邻居人妻中文字幕| 首页 综合国产 亚洲 丝袜 | 欧美饥渴少妇xxxxx性| 亚洲成熟丰满熟妇高潮xxxxx| 久久国产劲爆∧v内射-百度| 成人精品视频在线观看不卡| 国产剧情无码播放在线看| 久久无码人妻影院| 在线日韩日本国产亚洲| 亚洲熟妇av一区二区三区宅男| 顶级少妇做爰视频在线观看| 国产不卡视频一区二区三区| 国精产品999一区二区三区有限 | 国产乱xxxxx97国语对白| 中年人妻丰满av无码久久不卡| 麻豆国产成人av在线播放欲色| 日韩毛片无码永久免费看| 无码人妻精品一区二区三区久久久| 日韩精品真人荷官无码| 嫩草欧美曰韩国产大片| 免免费国产aaaaa片| 亚洲色成人网站www永久四虎 | 久久经精品久久精品免费观看| 真人作爱免费视频| av狠狠色超碰丁香婷婷综合久久| 久久不见久久见免费影院视频| 97精品国产手机| 色8久久人人97超碰香蕉987| 超薄丝袜足j好爽在线观看 |