在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC6A1 Antibody

  • 中文名稱:
    SLC6A1兔多克隆抗體
  • 貨號:
    CSB-PA935504
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA935504(SLC6A1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA935504(SLC6A1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: HepG2 cells, Primary antibody: CSB-PA935504(SLC6A1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SLC6A1
  • 別名:
    GABATHG antibody; GABATR antibody; GABT 1 antibody; GABT1 antibody; GAT-1 antibody; GAT1 antibody; SC6A1_HUMAN antibody; Slc6a1 antibody; Sodium and chloride dependent GABA transporter 1 antibody; Sodium- and chloride-dependent GABA transporter 1 antibody; Solute carrier family 6 (neurotransmitter transporter GABA) member 1 antibody; Solute carrier family 6 member 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human SLC6A1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
  • 基因功能參考文獻:
    1. Most patients carrying pathogenic SLC6A1 variants have an myoclonic atonic epilepsy phenotype with language delay and mild/moderate intellectual disability before epilepsy onset. However, intellectual disability alone or associated with focal epilepsy can also be observed. PMID: 29315614
    2. results suggest that selected SLC6A1 gene variants may have a significant effect on the ADHD risk. PMID: 28442423
    3. the "extra" residue in transmembrane domain 10 of the GABA transporter GAT-1 provides extra bulk, probably in the form of a pi-helix, which is required for stringent gating and tight coupling of ion and substrate fluxes in the GABA transporter family. PMID: 28213519
    4. Results show that SLC6A1 minor genotypes/alleles were protective against risk for alcoholism in 3 ethnically diverse cohorts. PMID: 26727527
    5. Protein expression as assessed by Western blot showed that GABA-transporter 1 was equally expressed in mild and severe hippocampal sclerosis PMID: 26212582
    6. Evidence for a Revised Ion/Substrate Coupling Stoichiometry of GABA Transporters. PMID: 25824654
    7. Genome-wide significant associations were highly biological plausible, including associations within GABA transporter 1, SLC6A1 (solute carrier family 6, member 1), and exonic hits in LOC100129340 (mitofusin-1-like PMID: 26081443
    8. targeted resequencing of 644 individuals with epileptic encephalopathies led to the identification of six SLC6A1 mutations in seven individuals, all of whom have epilepsy with myoclonic-atonic seizures (MAE). PMID: 25865495
    9. 3p25.3 microdeletion of GABA transporters SLC6A1 and SLC6A11 results in intellectual disability, epilepsy and stereotypic behavior. PMID: 25256099
    10. Cysteine mutagenesis of GAT-1 pointed to conformationally sensitive proximity of extracellular loops 2 and 4 in this protein. PMID: 25339171
    11. The aromatic and charge pairs of the thin extracellular gate of the GABA transporter GAT-1 are differently impacted by mutation. PMID: 25143384
    12. a functional interaction of the external and internal gates of GAT-1 is essential for transport PMID: 23288838
    13. analysis of binding and translocation processes in the GABA transporter PMID: 22737235
    14. TM10 of GAT-1 lines an accessibility pathway from the extracellular space into the binding pocket and plays a role in the opening and closing of the extracellular transporter gate. PMID: 22235131
    15. GABA Transporter Mutagenesis Database (GATMD), a web-accessible, relational database of manually annotated biochemical, functional and pharmacological data reported on GAT1. PMID: 21131297
    16. A glutamine residue conserved in the neurotransmitter:sodium:symporters is essential for the interaction of chloride with the GABA transporter GAT-1. PMID: 21098479
    17. This chapter reviews data suggesting that neurogliaform cells produce electrophysiological effects onto other neurons in the cortical cell network via GABA(B)R-mediated volume transmission that is highly regulated by GAT1 activity. PMID: 20655483
    18. A 46 bp cis-regulator in the promoter sequence is responsible for stimulation of bone morphogenetic protein-2 (BMP2) on gat1 expression in cerebral cortex. PMID: 20237276
    19. The results suggest tight coupling of GAT1-mediated charge flux and GABA flux. PMID: 19622377
    20. role of transmembrane domain I in transition between cation leak and transport modes PMID: 12446715
    21. part of extracellular loop IV of GAT1 is conformationally sensitive, and its modification selectively abolishes the interaction of the transporter with GABA PMID: 12925537
    22. the extracellular part of TMD I is conformationally sensitive, lines the permeation pathway, and forms a more extended structure than expected from a membrane-embedded alpha-helix. PMID: 14744863
    23. GAT1 over-expressing transgenic mice display cognitive deterioration in associative learning and new object recognition retention, compared with wild-type littermates. PMID: 15106822
    24. GAT1 oligomerization is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II PMID: 15496410
    25. transmembrane domains 1 and 3 come in close proximity within the transporter monomer PMID: 15905165
    26. there are substantial differences in the distribution and density of GAT-1-ir axon terminals between areas and layers of the human neocortex PMID: 17099065
    27. concentrative endoplasmic reticulum-export is contingent on a direct interaction of GAT1 with Sec24D. PMID: 17210573
    28. Weight reduction with sibutramine is associated with altered gastric functions and increased peptide YY and is significantly associated with SLC6A4 genotype. PMID: 17544870
    29. Owing to the low level of LD and presence of recombination hotspots, SLC6A1 may be an example of a problematic gene for association and haplotype tagging-based genetic studies PMID: 17941974
    30. It might therefore represent the principle, sufficient for sorting out less-effective or non-GAT ligands such as beta-Pro, (S)-nipecotic acid, (R)-baclofen, Glu, and Leu. PMID: 17967412
    31. The temperature and voltage dependence of GAT1 were used to estimate the physiological turnover rate to be 79-93 s(-1) (37 degrees C, -50 to -90 mV). PMID: 17994179
    32. Interaction with calnexin led to accumulation of GAT1 in concentric bodies corresponding to previously described multilamellar ER-derived structures. PMID: 18367207
    33. These data indicate a high load of genetic variance within SLC6A1 on pathological anxiety PMID: 18607529
    34. the insertion polymorphism leads to increased SLC6A1 promoter activity because, in part, of creation of an enhancer element when present as multiple copies PMID: 19077666
    35. the transmembrane domain 8 of the {gamma}-aminobutyric acid transporter GAT-1 lines a cytoplasmic accessibility pathway into its binding pocket PMID: 19201752

    顯示更多

    收起更多

  • 相關疾病:
    Myoclonic-atonic epilepsy (MAE)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Cell junction, synapse, presynapse.
  • 蛋白家族:
    Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A1 subfamily
  • 數據庫鏈接:

    HGNC: 11042

    OMIM: 137165

    KEGG: hsa:6529

    STRING: 9606.ENSP00000287766

    UniGene: Hs.443874



主站蜘蛛池模板: 欧美影院成年免费版| av无码人妻波多野结衣| 亚洲欧洲自拍拍偷精品网| 西西人体www44rt大胆高清| 国产成年无码v片在线| 欧美疯狂做受xxxxx高潮| 国产蝌蚪视频一区二区三区 | 国产成人无码a区在线观看导航| 人与禽交av在线播放| 极品国产主播粉嫩在线| 日韩精品成人av在线观看| 亚洲精品国产suv一区88| 免费男人下部进女人下部视频 | 色又黄又爽18禁免费网站现观看 | 久久精品国产只有精品2020| 精品久久久久久中文字幕大豆网| 久久久无码一区二区三区| 小sao货水好多真紧h无码视频 | 久久久亚洲欧洲日产国码农村 | 国产精品毛片在线完整版| 99久久er热在这里只有精品99| 国产高清在线a视频大全| 亚洲精品国产嫩草在线观看东京热| 国产精品爽爽ⅴa在线观看| 国产在线视频主播区| 欧美牲交a欧牲交aⅴ久久| 国产99久久九九精品无码| av片日韩一区二区三区在线观看 | 四虎永久在线精品8848a| 亚洲欧美在线观看品| 亚洲精品国产成人| 国产人妻精品一区二区三区| 国产ae86亚洲福利入口| 日本www网站色情乱码| 无码粉嫩虎白一线天在线观看| 亚洲偷自拍国综合| 撕开奶罩揉吃奶高潮av在线观看| 欧美日本韩国亚洲| 久久aⅴ无码av高潮av喷吹| 中文av伊人av无码av狼人| 人妻体验按摩到忍不住哀求继续 |