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SLC52A2 Antibody

  • 中文名稱:
    SLC52A2兔多克隆抗體
  • 貨號:
    CSB-PA060150
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of A549 cells using GPR172A Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SLC52A2
  • 別名:
    SLC52A2 antibody; GPR172A antibody; PAR1 antibody; RFT3 antibody; Solute carrier family 52 antibody; riboflavin transporter antibody; member 2 antibody; Porcine endogenous retrovirus A receptor 1 antibody; PERV-A receptor 1 antibody; Protein GPR172A antibody; Riboflavin transporter 3 antibody; hRFT3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human GPR172A.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption. May also act as a receptor for 4-hydroxybutyrate (Probable).; (Microbial infection) In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
  • 基因功能參考文獻:
    1. RFVT2 gene and protein expression levels were higher in DLD-1 and HT-29 compared to Caco2 cells. In tumor tissues of patients with CRC, RFVT2 gene expression levels were increased, while protein expression was reduced, with a small reduction in riboflavin amount. PMID: 29715086
    2. This is the second report of the genotype-phenotype correlation between this syndrome named spinocerebellar ataxia with blindness and deafness type 2 (SCABD2) and SLC52A2 gene. PMID: 29287867
    3. Eight mutations in SLC52a2 were associated with Brown-Vialetto-Van Laere syndrome. PMID: 29053833
    4. A novel SLC52A2 mutation identified in a family with spinocerebellar ataxia with blindness and deafness. PMID: 26669662
    5. This study showed that Auditory neuropathy in Brown-Vialetto-Van Laere syndrome due to riboflavin transporter RFVT2 deficiency and improved by riboflavin treatment. PMID: 26918385
    6. These results strongly implicate a potential role for SLC52A2 in riboflavin uptake by milk-producing MECs, a critical step in the transfer of riboflavin into breast milk. PMID: 26791833
    7. Mutations in SLC52A2 result in a recognizable phenotype distinct from Brown-Vialetto-Van-Laere syndrome. PMID: 24616084
    8. We demonstrate that SLC52A2 mutations cause reduced riboflavin uptake and reduced riboflavin transporter protein expression PMID: 24253200

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  • 相關疾病:
    Brown-Vialetto-Van Laere syndrome 2 (BVVLS2)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Riboflavin transporter family
  • 組織特異性:
    Highly expressed in brain, fetal brain and salivary gland. Weakly expressed in other tissues.
  • 數據庫鏈接:

    HGNC: 30224

    OMIM: 607882

    KEGG: hsa:79581

    STRING: 9606.ENSP00000333638

    UniGene: Hs.6459



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