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  4. SLC51B Antibody, Biotin conjugated

SLC51B Antibody, Biotin conjugated

  • 中文名稱：
    SLC51B兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA771440LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SLC51B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLC51B
  • 別名：
    SLC51B antibody; OSTB antibody; Organic solute transporter subunit beta antibody; OST-beta antibody; Solute carrier family 51 subunit beta antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Organic solute transporter subunit beta protein (57-128AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.
  • 基因功能參考文獻：
    1. Dileucine motif in the extracellular N-terminal region is essential for OSTB plasma membrane targeting. PMID: 27351185
    2. Hepatic OSTalpha-OSTbeta expression is induced by hypoxia. PMID: 24703425
    3. OSTbeta is a target of RARalpha-mediated (by binding to DR5 response element) gene regulation pathways PMID: 24264050
    4. Ostbeta is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta critical for these processes. PMID: 22535958
    5. The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta in different tissues. PMID: 21691099
    6. OSTbeta is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS homeostasis PMID: 20649839
    7. OSTbeta has roles in biological transport and is widely expressed in human tissues PMID: 12719432
    8. overexpression of human OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate and the activation of FXR target genes PMID: 16251721
    9. OSTalpha/OSTbeta expression is induced by bile acids through ligand-dependent transactivation of both OST genes by the nuclear bile acid receptor/farnesoid X receptor (FXR). PMID: 16269519
    10. the selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption. PMID: 16317684
    11. These results indicate that expression of Ostalpha and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor. PMID: 16423920
    12. Demonstrate association of OST-alpha and OST-beta to determine trafficking to plasma membrane and activity. PMID: 17332473
    13. The mRNA expression of OSTalpha-OSTbeta was significantly reduced (OSTalpha: 3.3-fold, P = 0.006; OSTbeta: 2.6-fold, P = 0.03) in normal-weight but not overweight gallstone carriers PMID: 18469300
    14. interaction of solute transporter beta with human organic solute transporter alpha. PMID: 18847488

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  • 亞細胞定位：
    Cell membrane; Single-pass membrane protein. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes.
  • 蛋白家族：
    OST-beta family
  • 組織特異性：
    Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 29956

    OMIM: 612085

    KEGG: hsa:123264

    STRING: 9606.ENSP00000335292

    UniGene: Hs.27018



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