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  4. SLC45A3 Antibody

SLC45A3 Antibody

  • 中文名稱：
    SLC45A3兔多克隆抗體
  • 貨號：
    CSB-PA836239LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA836239LA01HU diluted at 1:300 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA836239LA01HU diluted at 1:300 and staining in paraffin-embedded human prostate cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of HepG2 cells with CSB-PA836239LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SLC45A3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SLC45A3
  • 別名：
    IPCA 2 antibody; IPCA 8 antibody; IPCA6 antibody; PCANAP2 antibody; PCANAP6 antibody; PCANAP8 antibody; Prostate cancer associated gene 2 antibody; Prostate cancer associated gene 6 antibody; Prostate cancer associated gene 8 antibody; Prostate cancer associated protein 2 antibody; Prostate cancer associated protein 6 antibody; Prostate cancer associated protein 8 antibody; Prostate cancer-associated protein 6 antibody; Prostein antibody; PRST antibody; S45A3_HUMAN antibody; Slc45a3 antibody; Solute carrier family 45 member 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Solute carrier family 45 member 3 protein (408-487AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，SLC45A3 Antibody (CSB-PA836239LA01HU)，的標記方式是Non-conjugated。對于SLC45A3 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA836239LB01HU SLC45A3 Antibody, HRP conjugated ELISA
    FITC CSB-PA836239LC01HU SLC45A3 Antibody, FITC conjugated
    Biotin CSB-PA836239LD01HU SLC45A3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 基因功能參考文獻：
    1. Identification of a novel autoimmune peptide epitope of prostein in prostate cancer has been reported. PMID: 27700103
    2. CTCF has a role in regulating SLC45A3-ELK4 Chimeric RNA PMID: 26938874
    3. genome-wide association studies show that the top SNP associated with log PSA 9Prostate-specific antigen) levels was rs2153904 in SLC45A3. PMID: 25434496
    4. Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population. PMID: 23269536
    5. This study provides first evidence that the expression of SLC45A3 protein is down regulated through SLC45A3-ERG fusion in prostate cancer. PMID: 22821757
    6. Data suggest that chimeric SLC45A3-ELK4 controls prostate cancer cell proliferation, and the chimera level correlates with prostate cancer disease progression. PMID: 22719019
    7. Double sequential immunohistochemical staining with p63 and P501S is highly specific and can be a useful tool in distinguishing urothelial carcinoma from prostate carcinoma. PMID: 21777423
    8. This is the first study to report concurrent TMPRSS2 and SLC45A3 rearrangements in the same tumor focus in prostate cancer PMID: 20118910
    9. T cells that recognize naturally processed epitopes from prostein were expanded from healthy donors and characterized. T cells isolated from males were of low avidity and recognized subdominant epitopes while those from females were of higher avidity PMID: 15048720
    10. Prostein is expressed in the vast majority of prostatic tissues, regardless of grade and metastatic status. No expression was detected in 4,700 normal and malignant tissue samples representing the great majority of essential tissues and tumors. PMID: 15176054
    11. P501S is a sensitive and highly specific marker for identifying prostate tissue. Combined use of prostein/prostate specific antigen used to detect prostatic origin of metastatic carcinomas. PMID: 17721190
    12. A SLC45A3:ETV5 gene fusion was identified in prostate cancer. PMID: 18172298
    13. Intronic miRNAs from tissue-specific transcripts, or their natural absence, make cardinal contributions to cellular gene expression and phenotype. PMID: 18193184
    14. This study demonstrates that most ERG-overexpressing prostate cancers harbor hormonally regulated TMPRSS2-ERG, SLC45A3-ERG, or NDRG1-ERG fusions PMID: 19649210
    15. SLC45A3-ELK4 may represent the first description of a recurrent RNA chimaeric transcript specific to prostate cancer that does not have a detectable DNA aberration PMID: 19136943

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  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family
  • 組織特異性：
    Prostate specific. Expressed in all prostatic glandular cells. Expressed both in normal and cancerous prostates.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8642

    OMIM: 605097

    KEGG: hsa:85414

    STRING: 9606.ENSP00000356113

    UniGene: Hs.278695



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