在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SLC39A1 Antibody

  • 中文名稱:
    SLC39A1兔多克隆抗體
  • 貨號:
    CSB-PA008864
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    SLC39A1
  • 別名:
    hZIP1 antibody; IRT1 antibody; S39A1_HUMAN antibody; SLC39A1 antibody; Solute carrier family 39 member 1 antibody; Zinc transporter ZIP1 antibody; Zinc-iron-regulated transporter-like antibody; ZIP-1 antibody; ZIP1 antibody; ZIRTL antibody; Zrt- and Irt-like protein 1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human ZIP1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Mediates zinc uptake. May function as a major endogenous zinc uptake transporter in many cells of the body. Responsible for the rapid uptake and accumulation of physiologically effective zinc in prostate cells.
  • 基因功能參考文獻(xiàn):
    1. Despite the fact that these preliminary findings are unlikely to be of much diagnostic significance, these findings suggest that hZip1 plays a fundamental role in the carcinogenesis of mucinous tumors. PMID: 26081940
    2. Data indicate that zinc transporters ZnT1 and Zip1 were the most abundantly expressed zinc transporters in leukocytes. PMID: 24488210
    3. Data suggest that high zrt- and Irt-like protein 1 (hZIP1) expression may be an indicator of good prognosis in clear cell renal cell carcinoma (ccRCC). PMID: 24878177
    4. The effect of zinc administered for 27 days on the expression of ZIP1 in peripheral white blood cells is reported. PMID: 24922175
    5. RREB-1 overexpression results in down-regulation of hZIP1 and contributes to the loss of hZIP1 expression and zinc in prostate cancer. PMID: 21360563
    6. Data indicate that the average expression level of zinc transporter Zip2 was significantly higher and zinc transporters Zip6, Zip8 mRNA levels were significantly lower in short stature children than in health controls. PMID: 23921484
    7. Data indicate that the expression levels of ZnT and ZIP families in the three cell lines, when treated with high concentration of ZnSO4, increased and decreased corresponding to their functions, respectively. PMID: 23839533
    8. The results of this study showed that signi fi cant positive correlations between ZIP1,ZnT1, and ZnT6 in most brain in patient with Alzheimer's disease. PMID: 22349685
    9. The metallothionein gene had a higher expression in the blood, when compared to zinc transporters ZnT-1, Zip-1, and Zip-3 (p=0.01 in obese patients. PMID: 21053094
    10. Differentiated Caco-2 cells tolerate significantly higher levels of zinc compared to undifferentiated Caco-2 cells, which was accompanied by upregulated ZnT-1 and downregulated ZIP1 levels. PMID: 21103883
    11. GSPE and EGCG enhance the expression of cellular zinc importers ZIP1 (SLC39A1). PMID: 20471814
    12. the expression of human Zn transporter1 (hZIP1) appears to correlate with the Zn levels in the prostate glands and may be the major Zn regulator in this organ. PMID: 20705137
    13. Ras pathway and activation of RREB-1 are involved in hZIP1 down-regulation and may play a role in the decrease of the transporter expression in prostate cancer. PMID: 19802870
    14. zip1 mechanism of transport appears to involve the transport of zinc from low molecular weight ligands that exist in circulation as relatively loosely bound complexes with zinc PMID: 12888280
    15. ZIP1, ZIP2 and ZIP3 may play cell-specific roles in zinc homeostasis rather than primary roles in the acquisition of dietary zinc PMID: 14525987
    16. down regulation of hZIP1 is a critical early event in the development prostate cancer PMID: 16153295
    17. In conclusion, these studies provide important insights into the role of a plasma membrane zinc transporter (ZIP1) in the initiation of an osteogenic lineage from MSCs. PMID: 16203195
    18. di-leucine sorting signal of ZIP1 was required and sufficient for endocytosis of the chimeric proteins PMID: 17635580
    19. Gene expression regulation of ZIPs after zinc supplementation. PMID: 18279033
    20. results show that hZIP1 overexpression has a functional effect on the malignant potential of prostate cancer cells via inhibition of NF-kappaB-dependent pathways and support the concept that hZIP1 may function as a tumor suppressor gene PMID: 18765529
    21. The core promoter region responsible for constitutive expression of hZip1 were identified and critical roles for SP1 and CREB1 in transcriptional regulation of the hZip1 gene in prostate cancer cells, was demonstrated. PMID: 19026724
    22. ZIP is a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis PMID: 19644445

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines.
  • 蛋白家族:
    ZIP transporter (TC 2.A.5) family
  • 組織特異性:
    Ubiquitous. Expressed in most adult and fetal tissues including the epidermis.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 12876

    OMIM: 604740

    KEGG: hsa:27173

    STRING: 9606.ENSP00000309710

    UniGene: Hs.743291



主站蜘蛛池模板: 亚欧免费无码aⅴ在线观看| 亚洲欧美日韩综合久久久| 国产精品高潮呻吟av久久无吗| 久久精品成人免费观看三| 亚洲国产日韩一区三区| 亚洲综合在线一区二区三区| 人人超人人超碰超国产97超碰| 亚洲精品久久无码av片| 久久亚洲精品无码网站| 亚洲性色av性色在线观看 | 国产国产精品人在线视| 国产成人精品视频一区二区不卡| 成年男人裸j照无遮挡无码| 国产欧美另类久久久精品丝瓜| 精品国产电影久久九九| 无码视频一区二区三区| 牛牛视频一区二区三区| 国产 麻豆 日韩 欧美 久久| 成人看片黄a免费看在线| 亚洲人成在线观看影院牛大爷| 国产福利永久在线视频无毒不卡| 国产一区二区三区美女| 99久久久无码国产精品性| 日本精品αv中文字幕| 国产成人无码精品久久涩吧| 日韩av无码精品一二三区| 精品少妇人妻av一区二区| 极品美女在线观看免费直播| 国产+成+人+亚洲欧洲自线| 国产成人无码午夜视频在线播放| 18禁黄无遮挡网站| 日韩精品一区二区三区在线观看l| 亚洲熟妇丰满大屁股熟妇图片| 国产av国片精品jk制服丝袜| 少妇人妻偷人精品视蜜桃| 无码国产成人午夜视频在线播放| 国产99视频精品免费视频6| 欧美午夜精品久久久久免费视| 亚洲日韩精品欧美一区二区 | 狠狠97人人婷婷五月| 久久aⅴ无码av高潮av喷吹 |